Progress of metabolomics technology in diabetic retinopathy

doi:10.3760/cma.j.issn.1673-5803.2021.01.009

International Review of Ophthalmology ›› 2021, Vol. 45 ›› Issue (1): 44-50.doi: 10.3760/cma.j.issn.1673-5803.2021.01.009

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Progress of metabolomics technology in diabetic retinopathy

Zhou Zixi， Zheng Zheng， Zheng Minming

Department of Ophthamology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China

Received:2020-09-09 Online:2021-02-22 Published:2021-03-01
Contact: Zheng Zheng，Email: 163193841@qq.com E-mail:163193841@qq.com
Supported by:
Chongqing Natural Science Fundation （cstc2019jcyj-msxmX028）；Project of Chongqing Health and Family Planning Commision （ZY201602085）

Abstract

Abstract: Metabolomics is an emerging discipline that studies the whole and changes of endogenous metabolites produced by biological systems after external stimuli or disturbances. The common feature of diabetic retinopathy (DR) metabolomics is the significant enrichment of the three major metabolic pathways and the ascorbic acid pathway, including d\|glucose, 2\|deoxyribonate, asparagine, glutamine, arginine, citrulline, and proline and carnitine content increased, ascorbic acid，aspartic acid and glutamic acid content decreased.

Key words: diabetic retinopathy, metabolomics, biomarkers, metabolic pathway

Zhou Zixi, Zheng Zheng, Zheng Minming. Progress of metabolomics technology in diabetic retinopathy[J]. International Review of Ophthalmology, 2021, 45(1): 44-50.

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Progress of metabolomics technology in diabetic retinopathy

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