The mechanism of palmitoethanolamide in the treatment of glaucoma

doi:10.3760/cma.j.issn.1673-5803.2021.06.002

International Review of Ophthalmology ›› 2021, Vol. 45 ›› Issue (6): 471-476.doi: 10.3760/cma.j.issn.1673-5803.2021.06.002

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The mechanism of palmitoethanolamide in the treatment of glaucoma

Tang Liying^1,2, Xie Tingyu², Zhang Mouxin³, Liu Zuguo¹

¹Eye Institute of Xiamen University, Xiamen 361022, China; ²Department of Ophthalmology, Zhongshan Hosipital of Xiamen University, Xiamen 361004, China; ³Affiliated Xiamen Eye Center of Xiamen University, Xiamen 361004, China

Received:2021-03-15 Online:2021-12-22 Published:2021-12-22
Contact: Liu Zuguo, Email: zuguoliu@xmu.edu.cn
Supported by:
National Key R&D Program of China(2018YFA0107304); National Natural Science Foundation of China(81870627); Fundamental Research Funds for the Central Universities(20720202013)

Abstract

Abstract: Palmitoylethanolamide(PEA) is a member of fatty acid ethanolamide(FAE) family. At present, PEA has been proved to reduce intraocular pressure, regulate blood supply of optic nerve and neuroprotective effects, and may become a new approach for the treatment of glaucoma. PEA may treat glaucoma by regulating aqueous outflow channel, inhibiting inflammatory response, regulating blood supply to optic nerve and protecting optic nerve. (Int Rev Ophthalmol, 2021, 45: 471-476)

Key words: N-palmitoylethanolamide, glaucoma, intraocular pressure, nerve protection

Tang Liying, Xie Tingyu, Zhang Mouxin, Liu Zuguo. The mechanism of palmitoethanolamide in the treatment of glaucoma[J]. International Review of Ophthalmology, 2021, 45(6): 471-476.

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The mechanism of palmitoethanolamide in the treatment of glaucoma

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