Abstract: Vernal keratoconjunctivitis occurs in children and adolescents due to chronic inflammation prone to complications such as keratoconus. The treatment of ordinary keratoconus focuses more on mechanical correction (such as corneal cross-linking, rigid breathable contact lenses) or corneal transplantation surgery, and postoperative management is relatively simple. The treatment methods for vernal keratoconjunctivitis combined with keratoconus are similar to those for ordinary keratoconus, which include early keratoconus wearing contact lenses for visual correction, the inner ring of corneal stroma for improving the visual acuity of patients, corneal cross-linking for preventing the progression of keratoconus, penetrating keratoplasty and deep anterior lamellar keratoplasty for provide some patients with good visual effects and high graft survival rate. However, the treatment of vernal keratoconjunctivitis combined with keratoconus is complex, mainly due to the chronic inflammation and allergic reactions in the eyes that may affect surgical outcomes and postoperative recovery. Priority should be given to controlling inflammation, surgical selection should be more cautious, and postoperative management should be stricter. Early intervention and personalized treatment for vernal keratoconjunctivitis combined with keratoconus are key. (Int Rev Ophthalmol, 2025, 49:  147-152)

Key words: vernal keratoconjunctivitis, keratoconus, treatment