武汉市确诊COVID-19眼科医务人员的眼部症状调查研究

doi:10.13281/j.cnki.issn.1004-4469.2020.05.003

眼科

武汉市确诊COVID-19眼科医务人员的眼部症状调查研究

张慧¹ 乔春艳¹陈长征² 宋艳萍³ 刘中华⁴邢怡桥² 肖泽锋⁵ 柯敏⁶罗继红⁷ 叶娅³ 田宁¹何明光⁸ 应桂双⁹ 韩颖¹⁰ 王宁利¹

¹首都医科大学附属北京同仁医院北京同仁眼科中心眼科学与视觉科学北京市重点实验室北京市眼科研究所 100730；² 武汉大学人民医院眼科中心430000；³解放军中部战区总医院眼科中心，武汉 430070；⁴武汉市汉口医院眼科430312；⁵武汉市第一医院（武汉市中西医结合医院）眼科 442000；⁶武汉大学中南医院眼科430071；⁷湖北省中医院湖北省中医药研究院湖北中医药大学附属医院眼科，武汉430060；⁸ 澳大利亚眼科研究中心墨尔本大学维多利亚皇家眼耳医院，澳大利亚东墨尔本VIC 3152；⁹ 宾夕法尼亚州立大学佩雷尔曼医学院眼科，美国费城19104；¹⁰ 加利福尼亚大学旧金山分校眼科，美国加利福尼亚州旧金山 94131

收稿日期:2020-07-13 出版日期:2020-09-25 发布日期:2020-09-25
通讯作者: 王宁利，Email: wningli@vip.163.com
基金资助:
国家自然科学基金（81570837）

A survey on ocular manifestations of eye professionals diagnosed COVID-19 in Wuhan, China

Zhang Hui¹, Qiao Chunyan¹, Chen Changzheng², Song Yanping³, Liu Zhonghua⁴, Xing Yiqiao², Xiao Zefeng⁵, Ke Min⁶, Luo Jihong⁷, Ye Ya³, Tian Ning¹, He Mingguang⁸, Ying Guishuang⁹, Han Ying¹⁰, Wang Ningli¹

¹Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Institute of Ophthalmology, Beijing 100730, China; ² Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430000, China; ³ Department of Ophthalmology, Central Theater Command General Hospital, Wuhan 430070, China; ⁴Department of Ophthalmology, Hankou Hospital, Wuhan 430312, China; ⁵ Department of Ophthalmology, Wuhan No. 1 Hospital, Wuhan 442000, China;⁶ Department of Ophthalmology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China; ⁷ Department of Ophthalmology, Hubei Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Hubei University of Chinese Medicine, Hubei Province Academy of Traditional Chinese Medicine, Wuhan 430060, China;⁸ Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC 3152 Australia; ⁹Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia 19104 USA; ¹⁰ Department of Ophthalmology, University of California, San Francisco, California 94131 USA

Received:2020-07-13 Online:2020-09-25 Published:2020-09-25
Contact: Wang Ningli, Email: wningli@vip.163.com
Supported by:
National Natural Science Foundation (81570837)

摘要/Abstract

摘要： 目的调查武汉眼科医务人员确诊COVID-19的眼部症状情况。设计横断面问卷调查。研究对象 2020年2月26日至3月20日武汉确诊COVID-19的28例眼科医务人员为病例组，根据1:3~4的比例随机抽取病例组所在医院未感染的96例眼科医务人员作为对照组。方法使用“问卷网”进行问卷调查。主要指标 被调查者的基本信息、新冠病毒核酸检测结果、眼部症状。结果病例组26例（92.9%）及对照组96例（100%）完成问卷调查。病例组平均年龄（41.9±11.7）岁，分布在武汉10所综合性及眼科专科医院，确诊时间为2020年1月16日至2月29日；对照组平均年龄（35.1±5.5）岁。感染组中女性19例（67.9%）；医生14例（50%），护士12例（42.9%），技师2例（7.1%）；感染时从事眼科临床工作者19例（67.9%），从事抗疫一线工作者9例（32.1%）。病例组重症8例（28.6%）（包括死亡3例，危重症1例），咽拭子核酸检测阳性15例（53.6%）。病例组中25.7%的人认为工作环境通风条件较差。病例组11例（42.3%）有眼部症状，显著高于对照组（15.6%）（P=0.003）。其中，眼痒10例（90.9%）显著高于对照组（73.3%）（P=0.001），流泪4例（36.4%）显著高于对照组（13.3%）（P=0.02）；病例组异物感7例（63.6%），眼红2例（18.2%），视物模糊2例（18.2%）。4例行结膜囊核酸检测的患者中1例阳性。轻症20例中9例（45%）有眼部症状，重症6例中2例（33.3%）有眼部症状。结论武汉眼科医务人员COVID-19患者中约40%存在眼部症状。尽管结膜囊新冠病毒核酸检测样本量少，但证实结膜囊中确实存在新冠病毒。（眼科， 2020， 29： 332-338）

关键词: 新型冠状病毒肺炎, 眼科医护工作者, 问卷调查, 个人防护, 眼部症状

Abstract: Objective To investigate the infection-related factors, ocular manifestations and transmission routes of coronavirus disease 2019 (COVID-19) in the hospitals with eye professionals diagnosed symptomatic COVID-19 in Wuhan. Design Cross-sectional case-control questionnaire survey. Participants A total of 28 eye professionals who contracted COVID-19 in Wuhan, and 96 non-infected control subjects who were randomly selected with a 1 to 3-4 ratio within each case’s own hospital from February 26, 2020 to March 20, 2020. Method The "questionnaire network" was used to design the questionnaire and the data were downloaded from the background of the "questionnaire network". Main Outcome Measures The general information of eye professionals, their 2019-novel corona virus (2019-nCoV) PCR results, ocular symptoms, and treatments. Results A total of 28 eye professionals were diagnosed COVID-19 from January 16, 2020 to February 29, 2020 with an average age of 41.9±11.7(29-70) years old, from 10 general and ophthalmic hospitals in Wuhan. The control group included 96 eye professionals with an average age of 35.1±5.5(26-52) years old. There were 19 female subjects(67.9%), 14 doctors (50%), 12 nurses (42.9%), 2 technicians (7.1%) in the case group. 19 subjects(67.9%) worked in ophthalmology department and 9 subjects(32.1%) worked in anti-epidemic front line, which was no significant different compared with the control group. There are 8 severe cases(28.6%) (including 3 deaths and 1 critical case) in the case group. Reverse-transcriptase polymerase chain reaction (RT-PCR) of nasopharyngeal swabs were positive for 2019-nCoV in 15 cases(53.6%). 25.7% of infected medical workers found the working environment poorly ventilated. The questionnaire was completed in 26 cases (92.9% response rate) and 96 controls (100% response rate). There was a higher rate of concurrent ocular symptoms in 11 cases(42.3%) with COVID-19 than those (15.6%) in the control group (P=0.003). Among them, 10 cases(90.9%) with eye itching significantly higher than the control group (73.3%) (P=0.001), 4 cases (36.4%) with tearing significantly higher than the control group (13.3%) (P=0.02), 7 cases (63.6%) with foreign body sensation, 2 cases(18.2%) with eye redness, and 2 cases (18.2%) of blurred vision in case group. Among 4 subjects tested for 2019-nCoV PCR of conjunctival swabs, 1 subject (3.6% of total 28) was positive. Ocular symptoms were found in 9 cases(45%) of 20 mild cases and in 2 cases(33.3%) of 6 severe cases. There was no significant correlation between COVID-19 severity and ocular symptoms. Conclusion This questionnaire survey found that 42.3% of COVID-19 patients had ocular symptoms. Conjunctival sac 2019-nCoV test existed positive confirmed that there was 2019-nCoV in conjunctival sac. Eye professionals who are at a high risk of COVID-19 infection, need to pay attention to conjunctivitis symptoms patients and strengthen ocular medical protection to prevent the nosocomial spread of COVID-19. （Ophthalmol CHN, 2020, 29: 332-338）

Key words: novel-corona virus disease 2019, eye professionals, questionnaires, personal protective equipment, ocular manifestations

张慧乔春艳陈长征宋艳萍刘中华邢怡桥肖泽锋柯敏罗继红叶娅田宁何明光应桂双韩颖王宁利. 武汉市确诊COVID-19眼科医务人员的眼部症状调查研究[J]. 眼科, doi: 10.13281/j.cnki.issn.1004-4469.2020.05.003.

Zhang Hui, Qiao Chunyan, Chen Changzheng, Song Yanping, Liu Zhonghua, Xing Yiqiao, Xiao Zefeng, Ke Min, Luo Jihong, Ye Ya, Tian Ning, He Mingguang, Ying Guishuang, Han Ying, Wang Ningli. A survey on ocular manifestations of eye professionals diagnosed COVID-19 in Wuhan, China[J]. Ophthalmology in China, doi: 10.13281/j.cnki.issn.1004-4469.2020.05.003.

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武汉市确诊COVID-19眼科医务人员的眼部症状调查研究

A survey on ocular manifestations of eye professionals diagnosed COVID-19 in Wuhan, China

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