眼科 ›› 2022, Vol. 31 ›› Issue (5): 330-333.doi: 10.13281/j.cnki.issn.1004-4469.2022.05.002

• 专家讲座 • 上一篇    下一篇

与年龄相关性黄斑变性有关的细胞外沉积:基板沉积

黄厚斌   

  1. 解放军总医院眼科医学部,北京100853;解放军总医院海南医院眼科,三亚 572013;南方医科大学第二临床医学院,广州 510280
  • 收稿日期:2022-05-10 出版日期:2022-09-25 发布日期:2022-09-26
  • 通讯作者: 黄厚斌,Email:536273642@qq.com
  • 基金资助:
    海南省重点研发计划高新技术项目(ZDYF2020031);军委后勤保障部保健专项科研课题面上项目(19BJZ39)

Extracellular deposits associated with age-related maculopathy: basal laminar deposit

Huang Houbin   

  1. Senior Department of Ophthalmology, PLA General Hospital, Beijing 100853, China; Department of Ophthalmology, Hainan Hospital of PLA General Hospital, Sanya 572013, China; The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510280, China
  • Received:2022-05-10 Online:2022-09-25 Published:2022-09-26
  • Contact: Huang Houbin, Email: 536273642@qq.com
  • Supported by:
    High and New Technology Project of Hainan Key Research and Development Plan (ZDYF2020031); Special Scientific Research Project of the Logistic Support Department of the Chinese Military Committee(19BJZ39)

摘要: 随着年龄增长,脂蛋白来源的碎片等沉积物除了堆积在视网膜色素上皮下外,还可沉积在视网膜色素上皮基底外侧细胞膜和视网膜色素上皮基板之间,表现为视网膜色素上皮基板增厚,称为基板沉积。基板沉积也与年龄相关性黄斑变性有关。虽然大多数时候临床上不可查见位于视网膜色素上皮下的基板沉积,但视网膜色素上皮萎缩后,基板沉积可在视网膜外层和视网膜色素上皮下腔之间,或者在视网膜色素上皮下液与外层视网膜之间形成一条明显的分界,OCT有时可以发现。(眼科,2022, 31: 330-333)

关键词: 脂蛋白来源的碎片, 基板沉积, 年龄相关性黄斑变性

Abstract: With age, many deposits predominantly lipoprotein-derived debris can accumulated in the basal lamina of basement membrane of retinal pigment epithelium (RPE) besides between the basal lamina of basement membrane of RPE and the inner collagenous layer of Bruch's membrane. This kind of deposit is called basal laminar deposit, while thickens the basal lamina of RPE. Basal laminar deposit is difficult to be detected clinically, while appears as a high reflex line by OCT between outer retina and sub-RPE space in the some case of RPE atrophy. (Ophthalmol CHN, 2022, 31: 330-333)

Key words: lipoprotein-derived debris, basal laminar deposit, age-related macular degeneration