关键词: 2型糖尿病, 视网膜血管管径, 血清类胡萝卜素

Abstract:  Objective To observe the association between serum carotenoid level and retinal vessel caliber in type 2 diabetic patients. Design Cross-sectional study.  Participants A total of 462 subjects with type 2 diabetes mellitus (T2DM) from the Desheng Diabetic Eye Study were enrolled in this study. Methods 21 subjects were excluded according to the inclusion and exclusion criteria. 189 patients with diabetes without retinopathy (DWR) and 252 patients with mild to moderate non proliferative diabetic retinopathy (NPDR) were included. Demographic and lifestyle characteristics were collected through questionnaires. All subjects underwent general physical and ophthalmic examinations. Serum carotenoid levels were detected by high performance liquid chromatography. The calibers of retinal vessels, including central retinal arteriolar equivalent (CRAE), central retinal vein equivalent (CRVE) and arteriovenous ratio (AVR), were measured by semi-automatic software. Variables of the two groups were compared. Multivariate Logistic regression analysis was used to analyze the association of serum carotenoid level with retinal vessel caliber. Main Outcome Measures CRAE, CRVE, AVR, serumcarotenoids level. Results The CRAE was 150.8±16.0 μm in DWR group and 149.9±14.4 μm in mild and moderate NPDR group (t=0.58, P=0.56). The CRVE was 220.9±22.2 μm in DWR group and 230.3±25.1 μm in mild and moderate NPDR group (t=3.97, P<0.001). The AVR were 0.68±0.06 in DWR group and 0.65±0.06 in mild and moderate NPDR group (t=4.85, P<0.001). After adjusting for other risk factors, serum zeaxanthin was positively associated with CRVE in DWR group (OR=4.03, 95%CI: 1.40, 19.62, P=0.01), and lycopene was positively associated with CRVE in mild and moderate NPDR group (OR=1.01, 95%CI: 1.0002, 1.02, P=0.01). Conclusions The CRVE of NPDR patients was significantly wider and the AVR was significantly lower than those of DWR subjects. Higher levels of serum zeaxanthin and lycopene were associated with wider CRVE. (Ophthalmol CHN, 2023, 32: 409-415)

Key words: type 2 diabetes mellitus, retinal vessel caliber, serumcarotenoids