干眼患者临床特征的多中心研究

doi:10.13281/j.cnki.issn.1004-4469.2024.02.007

眼科 ›› 2024, Vol. 33 ›› Issue (2): 120-125.doi: 10.13281/j.cnki.issn.1004-4469.2024.02.007

干眼患者临床特征的多中心研究

任杰^1，2，3 刘畅^1，2 周奇志^2，4 曾庆延^2，5 李玲^1，2 窦泽夏^1，2 王丛香^2，6 陈铁红⁷ 鲁静⁸ 晏艳霜^9，10 牛晓霞¹¹孙旭光^1，2，12 李绍伟^1，2，13

¹北京爱尔英智眼科医院，北京100021； ²爱尔角膜病研究所，北京 100021； ³首都医科大学附属北京潞河医院眼科，北京 101149； ⁴重庆眼视光医院，重庆 40000； ⁵汉口爱尔眼科医院，武汉 430060； ⁶长沙爱尔眼科医院，长沙 410015；⁷沈阳爱尔眼科医院，沈阳110003； ⁸成都爱尔眼科医院，成都 610000； ⁹广州爱尔眼科医院，广州 510040；¹⁰海南爱尔新希望眼科医院，海口 460000； ¹¹哈尔滨爱尔眼科医院，哈尔滨150000； ¹²首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科研究所，北京 100730； ¹³中南大学爱尔眼科学院，长沙 410000

收稿日期:2022-10-28 出版日期:2024-03-25 发布日期:2024-03-23
通讯作者: 李绍伟，Email：lishaowei@aierchina.com

Clinical characteristics of dry eye outpatients in China: a multicenter study

Ren Jie^{1, 2, 3}, Liu Chang^{1, 2}, Zhou Qizhi^{2, 4}, Zeng Qingyan^{2, 5}, Li Ling^{1, 2}, Dou Zexia^{1, 2}, Wang Congxiang^{2, 6}, Chen Tiehong⁷, Lu Jing⁸, Yan Yanshuang^{9, 10}, Niu Xiaoxia¹¹, Sun Xuguang^{1, 2, 12}, Li Shaowei^{1,2, 13}

¹ Beijing Aier Intech Eye Hospital, Beijing 100021, China; ² Aier Corneal Institute, Beijing 100021, China; ³ Department of Ophthalmology, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China; ⁴Chongqing Optometry Ophthalmic Hospital, Chongqing 400000, China; ⁵Hankou Aier Eye Hospital, Wuhan 430060, China; ⁶ Changsha Aier Eye Hospital, Changsha 410015, China; ⁷ Shenyang Aier Eye Hospital, Shenyang 110003, China; ⁸Chengdu Aier Eye Hospital, Chengdu 610000, China; ⁹ Guanzhou Aier Eye Hospital, Guangzhou 510040, China; ¹⁰ Hainan Aier New Hope Eye Hospital, Haikou 460000, China; ¹¹ Harbin Aier Eye Hospital, Harbin 150000, China; ¹² Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; ¹³ Aier School of Ophthalmology, Central South University, Changsha 410000, China

Received:2022-10-28 Online:2024-03-25 Published:2024-03-23
Contact: Li Shaowei, Email: lishaowei@aierchina.com

摘要/Abstract

摘要： 目的分析眼科门诊干眼患者的临床特征。设计多中心临床研究。研究对象 爱尔集团北京、重庆、汉口、长沙、沈阳、成都、广州、哈尔滨8个眼科医院干眼门诊4497例初诊为干眼的患者。方法回顾性分析2017年6月至2019年6月8个城市爱尔眼科医院初诊为干眼患者的临床资料。所有患者均行眼表疾病指数问卷量表（OSDI）调查、中国干眼问卷量表调查，荧光染色泪膜破裂时间（FBUT）、角膜荧光染色、泪液分泌试验（ST）及睑板腺检查。将干眼患者分为南方（重庆、武汉、长沙、成都、广州）、北方（北京、沈阳、哈尔滨）两组。干眼类型分为水液缺乏型、睑板腺功能障碍（MGD）相关型及混合型。干眼严重程度分为轻度、中度及重度。主要指标 OSDI评分、中国干眼问卷量表得分，FBUT、ST、睑板腺评分。结果 4497例患者中水液缺乏型127例（3.0%），MGD相关型2308例（53.7%），混合型1864（43.4%）。其中MGD 4172例，占总数的92.8%。轻度干眼3970例（88.3%）、中度381例（8.5%）、重度119例（2.6%）。北方组患者的ST为（8.1±6.6）mm，明显低于南方组患者的（9.6±7.4）mm（t=-6.470，P<0.001）；北方组患者的OSDI评分（22.3±14.4），明显高于南方组患者的（20.7±13.2）（t=3.652，P<0.001）；北方组患者的睑板腺分级评分（1.6±0.7），明显高于南方组患者的（1.5±0.7）（t=5.351，P<0.001）。北方的中度及重度干眼患者比例（9.9%，3.5%）较南方（5.4%，0.9%）高（χ2=52.669，P<0.001）。结论 MGD相关的干眼在中国干眼门诊患者中比例较高；中国北方干眼患者中度及重度比例较南方高。（眼科，2024，33： 120-125）

关键词: , 干眼, 睑板腺功能障碍, 多中心研究

Abstract: Objective To analyze the clinical characteristics associated with dry eye disease (DED) in China. Design Multicenter clinical research. Participants A total of 4497 patients with a diagnosis of DED from 8 Aier Eye Hospitals (Shenyang, Beijing, Harbin, Chongqing, Changsha, Chengdu, Wuhan and Guangzhou) in China. Methods The clinical data of patients with DED from June 2017 to June 2019 were collected. The Ocular Surface Disease Index (OSDI), the Chinese Dry Eye Questionnaire was administered, and ocular surface staining, Schirmer’s test, and fluorescein breakup time test (FBUT) were performed, and meibomian scores were calculated. The patients were classified into North group (Beijing, Shenyang, Harbin) and South group (Chongqing, Wuhan, Changsha, Chengdu, Guangzhou). The types of DED were purely aqueous deficient, purely evaporative and mixed-type groups. The severity of DED was graded into mild, moderate and severe. Main Outcome Measures OSDI, China Dry Eye Questionnaire, FBUT, Schirmer’s test, corneal fluorescent staining and meibomian gland score. Results A total of 4497 patients were included in the study. 127 cases (3.0%) were classified as having purely aqueous-deficient dry eye, 2308 cases (53.7%) were classified as having purely evaporative dry eye resulting from meibomian gland dysfunction (MGD), and 1864 cases (43.4%) were classified as having mixed-type dry eye. Overall, 92.8% of these patients showed signs of MGD. Among the patients, 3970 cases (88.3%) were mild, 381 cases (8.5%) were moderate and 119 cases (2.6%) were severe. The Schirmer test in North group (8.1±6.6 mm) was lower than that in South group (9.6±7.4)mm (t=-6.470, P<0.001). OSDI in North group (22.3±14.4) was higher than that in South group (20.7±13.2) (t=3.652, P<0.001), and meibomian scores in North group (1.6±0.7) was higher than that in South group (1.5±0.7) (t=5.351, P<0.001). The proportions of moderate (9.9%) and severe (3.5%) DED were higher in North group than that in South group (5.4%, 0.9%). Conclusion The proportion of dry eye patients associated with MGD is very high in many dry eye clinics in China. The proportions of moderate and severe DED were higher in North group than in South group in China. (Ophthalmol CHN, 2024, 33: 120-125)

Key words: , dry eye disease, meibomian gland dysfunction, multicenter study

任杰刘畅周奇志曾庆延李玲窦泽夏王丛香陈铁红鲁静晏艳霜牛晓霞孙旭光李绍伟. 干眼患者临床特征的多中心研究[J]. 眼科, 2024, 33(2): 120-125.

Ren Jie, Liu Chang, Zhou Qizhi, Zeng Qingyan, Li Ling, Dou Zexia, Wang Congxiang, Chen Tiehong, Lu Jing, Yan Yanshuang, Niu Xiaoxia, Sun Xuguang, Li Shaowei. Clinical characteristics of dry eye outpatients in China: a multicenter study[J]. Ophthalmology in China, 2024, 33(2): 120-125.

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干眼患者临床特征的多中心研究

Clinical characteristics of dry eye outpatients in China: a multicenter study

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