关键词: 氯替泼诺, 准分子激光原位角膜磨镶术

Abstract: Objective To compare the effects of three kinds of cortisteriod eye drops after laser in situ keratomileursis (LASIK) for myopia. Design Retrospective case series. Participants 300 patients (600 eyes) who accepted LASIK and were followed up for three month or more from Dec. 2009 to Feb. 2010 in Ningbo Eye Hospital were included. Methods The patients were divided into three groups according to the different  post-operative medicines: Loteprednol group, Dexamethasone group and Flumetholon group. There were 100 patients in each group. For all the three groups, uncorrected visual acuity(UCVA), spherical equivalent(SE), diffuse lamellar keratitis (DLK), the sensation of dry eye, intraocular pressure (IOP) were observed preoperatively and at 1st day, 1st week, 3rd week, 3rd month postoperatively. Main Outcome Measures UCVA, SE, the grade of DLK, the score of sensation of dry eye, and IOP. Results It was similar on the changes of UCVA and SE, the score of eye dry sensation and IOP after operation among three groups at different time point (all P>0.05). At 1st week after LASIK, the incidence of DLK was similar between Loteprednol group（1%） and Dexamethasone group（2%）, but significantly lower than Flumetholon group（15%, χ2=26.6 and 21.7, respectively, both P <0.01）. Corticosteroid-induced ocular hypertension happened in 2 cases in Dexamethasone group, while there was none in Loteprednol group and Flumetholon group. Conclusion Comparing with the Flumetholon eye drops, transient usage of Loteprednol eye drops after LASIK for myopia is effective to reduce DLK, which had similar effects as Dexamethasone eye drops, and corticosteroid-induced ocular hypertension was not observed. （Ophthalmol CHN， 2012，21： 336-339）

Key words: Loteprednol, laser in situ keratomileursis