临床前期急性闭角型青光眼眼前部巩膜厚度测量

眼科 ›› 2013, Vol. 22 ›› Issue (4): 249-252.

临床前期急性闭角型青光眼眼前部巩膜厚度测量

王洪涛王宁利李树宁牟大鹏

100730 首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科学与视觉科学重点实验室

收稿日期:2013-02-28 出版日期:2013-07-25 发布日期:2013-07-23
通讯作者: 王宁利，Email：wningli@vip.163.com

The comparison of anterior scleral thickness in fellow eyes of acute primary angle-closure glaucoma and in normals

WANG Hong-Tao, Wang-Ning-Li, Li-Shu-Ning, Mou-Da-Peng

Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Vis Sci Key Lab., Beijing 100730, China

Received:2013-02-28 Online:2013-07-25 Published:2013-07-23
Contact: WANG Ning-li, Email: Wningli@vip.163.com

摘要/Abstract

摘要： 目的探讨急性闭角型青光眼（APACG）与正常人前部巩膜厚度的差异。设计前瞻性比较性病例系列。研究对象北京同仁眼科中心APACG患者57例（57眼），同期正常人57例（57眼）。方法对上述患者行超声生物显微镜（UBM）检查测量眼前部巩膜厚度及中央角膜厚度；非接触眼压计测量眼压；IOL Master测量眼轴长度。眼前部巩膜厚度的测量取自颞侧象限巩膜突后2 mm处。组间各参数比较采用独立样本t检验；眼前部巩膜厚度与中央角膜厚度、眼压、眼轴的关系采用多元线性回归分析。主要指标眼前部巩膜厚度、眼压、中央角膜厚度、眼轴长度。结果APACG临床前期眼及正常对照眼的前部巩膜厚度分别为（625.42±41.45） ?滋m、（594.42±46.06） ?滋m，差异有统计学意义（t=3.78，P=0.0001）；中央角膜厚度分别为（537.08±34.68） ?滋m、（529.90±39.69） ?滋m，差异无统计学意义（t=1.03，P=0.153）；眼压分别为（16.70±3.75）、（17.00±3.92）mm Hg，差异无统计学意义（t=0.42，P=0.338）；眼轴长度分别为（20.78±1.23）、（23.56±2.21）mm，差异有统计学意义（t=8.30，P=0.000）。多元线性回归显示，APACG眼前部巩膜厚度与眼轴有关（P=0.009），前部巩膜厚度=877.144–12.135×眼轴。结论 APACG患者前部巩膜厚度较正常眼厚；这可能作为发病机制之一参与了APACG的急性发作。（眼科，2013，22： 249-252）

关键词: 急性原发性闭角型青光眼, 巩膜厚度

Abstract: Objective To measure and compare anterior scleral thickness in fellow eyes of acute primary angle-closure glaucoma (APACG) and in normal eyes. Design Prospective comparative case series. Participants Fifty seven fellow eyes of 57 patients with APACG and 57 normal eyes were enrolled. Methods Anterior sclera thickness (ST) and center corneal thickness (CCT) were measured with ultrasound biomicroscopy (UBM), and the images were obtained by a same examiner scanning the center corneal area and temporal corneoscleral limbus. ST was measured at 2.0 mm posterior to scleral spur. Axis length was measured with IOL Master. Intraocular pressure (IOP) was measured with non-contact tonometer. T test was performed, and multiple linear regressions were performed between anterior sclera thickness and other parameters. Main Outcome Measures IOP, CCT, anterior ST and axis length. Results In fellow eyes of APACG and in normal subjects, the mean anterior ST was (625.42±41.45) ?滋m, (594.42±46.06) ?滋m respectively (t=3.78, P=0.0001); the mean IOP was (16.70±3.75), (17.00±3.92) mm Hg respectively (t=0.42, P=0.338); the mean CCT was(537.08±34.68) ?滋m,(529.90±39.69) ?滋m respectively (t=1.03, P=0.153); the mean axis length was(20.78±1.23), (23.56±2.21) mm respectively (t=8.30, P=0.000). Multiple linear regression showed that in fellow eyes of APACG, the relationship between anterior ST and ocular axis had statistic significant (P=0.0090). Equation is Y (anterior ST) =877.144-12.135× (ocular axis ). Conclusion The thicker anterior sclera might be related to the acute episode of APACG attacks. (Ophthalmol CHN, 2013, 22: 249-252)

Key words: acute primary angle-closure glaucoma, scleral thickness

王洪涛, 王宁利, 李树宁, 牟大鹏. 临床前期急性闭角型青光眼眼前部巩膜厚度测量[J]. 眼科, 2013, 22(4): 249-252.

WANG Hong-Tao, Wang-Ning-Li, Li-Shu-Ning, Mou-Da-Peng. The comparison of anterior scleral thickness in fellow eyes of acute primary angle-closure glaucoma and in normals[J]. Ophthalmology in China, 2013, 22(4): 249-252.