眼科 ›› 2014, Vol. 23 ›› Issue (4): 235-239.doi: 10.13281/j.cnki.issn.1004-4469.2014.04.005

• 论著 • 上一篇    下一篇

非动脉炎性前部缺血性视神经病变视盘形态的Meta分析

马瑾  陈婷  单广良  钟勇   

  1. 100730北京,中国医学科学院 北京协和医学院 北京协和医院眼科(马瑾、陈婷、钟勇);中国医学科学院基础医学研究所 北京协和医学院基础学院流行病学与卫生统计学系(单广良) 
  • 收稿日期:2014-01-27 出版日期:2014-07-25 发布日期:2014-07-22
  • 通讯作者: 钟勇,Email:yzhong_eye@163.com

Meta analysis of optic disc morphology in nonarteritic anterior ischemic optic neuropathy

MA Jin1, CHEN Ting1, SHAN Guang-liang2, ZHONG Yong1    

  1.  1. Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing
  • Received:2014-01-27 Online:2014-07-25 Published:2014-07-22
  • Contact: ZHONG Yong, Email: yzhong_eye@163.com

摘要: 目的 采用Meta分析的方法评价非动脉炎性前部缺血性视神经病变(Nonarteritic anterior ischemic optic neuropathy,NAION)患者视盘形态特点。设计 系统综述。研究对象 检索万方全文数据库、EMBASE和Pubmed 数据库中有关NAION 患者视盘定量测量的临床研究文献。方法 依据纳入和排除标准筛选文献,对纳入的研究进行数据提取并进行meta分析,统计学采用Stata软件进行异质性检验、合并WMD和敏感性分析。主要指标 视盘形态学参数。结果 共7篇文献符合纳入标准。NAION患者对侧健眼与正常对照比较,视盘面积(WMD=-0.20,95%CI:-0.37~-0.03)、视杯面积(WMD=-0.36,95%CI:-0.58~-0.14)、杯盘面积比(WMD=-0.15,95%CI:-0.23~-0.06)、视杯容积(WMD=-0.08,95%CI:-0.12~-0.05)、平均视杯深度(WMD=-0.10,95%CI:-0.13~-0.06)、视杯形态测量(WMD=-0.03,95%CI:-0.05~-0.02)均小于正常对照组,差异有统计学意义;而盘沿面积(WMD=0.05,95%CI:-0.15~0.25)、盘沿容积(WMD=0.05,95%CI:-0.07~0.16)两组间差异无统计学意义。NAION患者患眼与对侧健眼比较,盘沿容积(WMD=-0.08,95%CI:-0.14~-0.02)较健眼小,视杯形态测量(WMD=0.03,95%CI:0.00~0.06)较健眼大,差异有统计学意义;视盘面积(WMD=0.08,95%CI:-0.04~0.19)、视杯面积(WMD=0.08,95%CI:-0.01~0.17)、盘沿面积(WMD=-0.05,95%CI:-0.17~0.08)、杯盘面积比(WMD=0.02,95%CI:-0.02~0.06)、视杯容积(WMD=0.01,95%CI:-0.02~0.03)、平均视杯深度(WMD=0.00,95%CI:-0.02~0.03)差异两组间无统计学意义。结论NAION患者具有小视盘、小视杯的特点;NAION发生后,视杯有扩大趋势。(眼科,2014, 23: 235-239)

关键词: 非动脉炎性前部缺血性视神经病变, 视盘形态, meta分析

Abstract: Objective To investigate the feature of optic disc morphology in nonarteritic anterior ischemic neuropathy (NAION). Design Systemic review. Participants A comprehensive literature research was conducted for published studies reporting both optic disc morphology and NAION from CNKI, EMBASE and Pubmed database. Methods Based on inclusion and exclusion criteria, the study included data extraction and meta-analysis. Pooled WMD, heterogeneity and sensitivity analysis were calculated with Stata software. Main Outcome Measures Parameters of optic disc morphology. Results Between unaffected fellow eyes of NAION patients group and control group, the disc area (WMD=-0.20, 95%CI:-0.37~-0.03), cup area (WMD=-0.36, 95%CI:-0.58~-0.14), cup/disc area ratio (WMD=-0.15,  95%CI:-0.23~-0.06), cup volume (WMD=-0.08, 95%CI:-0.12~-0.05), mean cup depth (WMD=-0.10, 95%CI:-0.13~-0.06) and cup shape measure (WMD=-0.03, 95%CI:-0.05~-0.02) were smaller in the unaffected eyes, whereas there were no significant differences in rim area (WMD=0.05, 95%CI:-0.15~0.25) and rim volume (WMD=0.05, 95%CI:-0.07~0. 16). When the same parameters were compared between the affected and unaffected eyes of the patients with unilateral NAION, smaller rim volume (WMD=-0.08, 95%CI:-0.14~- 0. 02) and greater cup shape measure (WMD=0.03, 95%CI: 0.00~0.06) were in eyes after NAION, while the other optic disc parameters showed no correlations. Conclusion Small disc and small cup is the characteristic feature in the NAION, and after NAION there is a trend toward cupping compared with the fellow eye. (Ophthalmol CHN, 2014, 23: 235-239) 

Key words: nonarteritic anterior ischemic optic neuropathy, optic disc morphology, Meta-analysis