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3.2 mm透明角膜切口超声乳化术治疗放射状角膜切开术后白内障的效果及安全性
 

刘雪  王进达  张景尚  熊瑛  李婧  李晓霞  赵晶  万修华   

  1. 100005  首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科研究所 眼科学与视觉科学北京市重点实验室
  • 收稿日期:2015-09-15 出版日期:2015-11-25 发布日期:2015-12-03
  • 通讯作者: 万修华,Email:xiuhuawan@163.com E-mail:xiuhuawan@163.com
  • 基金资助:

    北京市科技新星(H020821380190,Z131102000413025);国务院妇女儿童工作委员会课题(2014108);国家自然科学基金面上项目(30471861)

Efficacy and safety of phacoemulsification with 3.2 mm clear corneal incision for cataract after radial keratotomy

LIU Xue, WANG Jin-da, ZHANG Jing-shang, XIONG Ying, LI Jing, LI Xiao-xia, ZHAO Jing, WAN Xiu-hua   

  1. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China
  • Received:2015-09-15 Online:2015-11-25 Published:2015-12-03
  • Contact: WAN Xiu-hua, Email: xiuhuawan@163.com E-mail:xiuhuawan@163.com

摘要:

目的  评估3.2 mm透明角膜切口超声乳化术治疗放射状角膜切开术(radial keratotomy,RK)后白内障的效果与安全性。设计  回顾性病例系列。研究对象  既往有RK手术史的白内障患者8例13眼,其中RK角膜瘢痕为8刀者2例4眼,12刀者3例4眼,16刀者3例5眼。方法  由同一手术医师进行3.2 mm透明角膜切口超声乳化人工晶状体植入术。8刀RK组中,角膜主切口位于相邻两条放射状角膜瘢痕之间,未与瘢痕接触;12刀RK组中,主切口跨越1条角膜瘢痕;16刀RK组中,主切口跨越2条角膜瘢痕。于术后1天,1周,1、3、6个月,1、2、3年进行随访,观察角膜RK瘢痕情况、并发症处理及术后视力恢复情况。主要指标 有无RK瘢痕裂开、术后最佳矫正视力、角膜散光、角膜内皮细胞密度。结果  8刀RK组和12刀RK组术中均未发生角膜RK瘢痕裂开,术毕切口密闭良好;16刀RK组中,2眼发生术中角膜瘢痕裂开,1眼采用前房注气封闭切口,另1眼采用主切口下注入黏弹剂,侧切口前房注气封闭切口。随访过程中,所有13眼术后角膜切口密闭良好,均未出现新发角膜瘢痕裂开。最后1次复查时,最佳矫正视力为(0.67±0.18)较术前(0.29±0.20)提高(t=-6.077,P=0.000),角膜散光(1.69±1.23 D)较术前(1.28±0.78 D)无明显变化(t=-0.758,P=0.470),角膜内皮细胞密度(1716.95±906.79/mm2)较术前(2383.97±833.39/mm2)降低(t=2.995,P=0.012)。结论  8刀、12刀RK术后白内障患者行超声乳化手术时采用3.2 mm透明角膜切口是安全的,16刀者术中易发生角膜瘢痕裂开,对此应采用更小的角膜切口或采用传统的角巩膜隧道切口。

关键词: 白内障/外科学, 放射状角膜切开术

Abstract:

Objective To evaluate the efficacy and safety of phacoemulsification with 3.2 mm clear corneal incision for the cataract patients after radial keratotomy (RK). Design Retrospective cases series. Participants Patients with cataractous lens with previous RK 8 cases (13 eyes). In which, 2 cases (4 eyes) with 8 incisions RK, 3 cases (4 eyes) with 12 incisions RK and 3 cases (5 eyes) with 16 incision RK. Methods Phacoemulsification and IOL implantation was performed through 3.2 mm clear corneal incision by the same surgeon. In the 8 incisions RK group, the clear corneal incision was performed between the adjacent RK incisions without intersecting the RK incisions. In the 12 incisions RK group, the clear corneal incision intersected 1 RK incision. In the 16 incisions RK group, the clear corneal incision intersected 2 adjacent RK incisions. The condition of RK incisions, management of complications and postoperative visual acuity was observed at 1 day, 1 week, 1 month, 3 months, 6 months, 1 year, 2 years and 3 years after the surgery. Main Outcome Measures Presence or absence of RK incision dehiscence during or after the surgery, postoperative best-corrected visual acuity (BCVA), corneal astigmatism, and corneal endothelial cell density. Results No RK incision dehiscence noted in all the 8 and 12 RK incisions groups and the clear corneal incisions were well apposed. Dehiscence was noted in one of the adjacent RK incisions in 2 eyes of the 16 RK incisions group. The dehiscences of RK incisions were closed by injecting air bubble with and without viscoelastic agent into the anterior chamber. During the follow-up, the incisions were well apposed in all of the 13 eyes and no new dehiscence of RK incisions occurred. In the last follow-up, the mean of BCVA (0.67±0.18) was better than preoperative BCVA(0.29±0.20)(t=-6.077, P=0.000); There was no significant difference between the final postoperative (1.69 ± 1.23 D) and preoperative corneal astigmatism (1.69±1.23 D)(t=-0.758, P= 0.470); while the mean postoperative corneal endothelial cell density (1716.95±906.79/mm2) was significantly less than the mean preoperative corneal endothelial cell density(2383.97±833.39/mm2) (t=2.995, P=0.012). Conclusion Phacoemulsification and IOL implantation with a 3.2 mm clear corneal incision in eyes with previous 8 and 12 incisions RK is safe. While a manageable dehiscence is possible to occur in eyes with previous 16 RK incisions, it suggests the smaller clear corneal incision or scleral tunnel incision should be used in eyes with 16 RK incisions.

Key words: cataract/surgery, radial keratotomy