关键词: 眶周, 毛母质瘤, 儿童 

Abstract:  Objective To explore the clinical and pathological characteristics of periorbital pilomatricoma in children. Design Retrospective case series. Participants 112 children with periorbital pilomatricoma who underwent surgical treatment in Children's Hospital of Zhejiang University School of Medicine from January 2014 to June 2020. Methods The clinical and pathological data of all patients including the age, gender, location of onset, ultrasound and pathological characteristics were reviewed. Main Outcome Measures Children's age, sex, location of onset, ultrasound and pathological characteristics of the tumor. Results 112 cases of children had an operating age of 7 months to 11 years and 2 months, with median operating age of 3 years and 8 months. 54 cases were males. 74 cases (66.1%) located in the eyebrow, 29 cases (25.9%) in the upper eyelid, 7 cases (6.2%) in the lower eyelid, and 2 cases (1.8%) in the inner canthus of the eyelid. 57 cases underwent preoperative ultrasound examination, 38 cases (66.8%) had calcification in the tumor, and 38 cases (66.8%) had blood flow signals in or around the tumor. Histopathological examination showed shadow cells and basophils, of which 91 cases (81.3%) had calcifications. 78 cases (69.6%) showed multinucleated giant cell response. All cases were surgically removed, and there was no recurrence or malignant transformation after surgery. Conclusion Children with periorbital subcutaneous nodules should consider the possibility of pilomatricoma. Ultrasonography has a certain diagnosis value for periorbital pilomatricoma. Early surgical complete resection is effective treatment. (Ophthalmol CHN, 2021, 30: 379-383)

Key words: periorbital, pilomatricoma, children