眼科 ›› 2026, Vol. 35 ›› Issue (5): 386-392.doi: 10.13281/j.cnki.issn.1004-4469.2026.05.007

• 论著 • 上一篇    下一篇

后囊膜连续环形撕囊术对白内障术后黄斑区脉络膜毛细血管血流密度与中心凹视网膜厚度的影响

翟欣然1, 2   李佳鱼 1, 2  马高阳1   秦娜1, 2   曹赫 2, 3  马树旗1, 2  刘延东2  杨宏宇2   张印博2  李瑞芳2   单丽2   梁肃2  张越2   

  1. 1 河北省眼科医院 河北省眼科学重点实验室 河北省眼部疾病临床医学研究中心,河北邢台054001;2河北医科大学眼科学教研室,石家庄050017;3华北理工大学临床医学院眼科学教研室,河北唐山063210
  • 收稿日期:2026-01-26 出版日期:2026-09-25 发布日期:2026-09-18
  • 通讯作者: 张越,Email:zhangyueyk@163.com
  • 基金资助:
    邢台市重点研发计划自筹项目(2023ZC175);中央引导地方科技发展资金项目(基础研究项目)(264Z7766G)

Impact of posterior continuous curvilinear capsulorhexis on macular choroidal capillary vessel density and central macular thickness after cataract surgery

Zhai Xinran1, 2, Li Jiayu1, 2, Ma Gaoyang1, Qin Na1, 2, Cao He2, 3, Ma Shuqi1, 2, Liu Yandong2, Yang Hongyu2, Zhang Yinbo2, Li Ruifang2, Shan Li2, Liang Su2, Zhang Yue2   

  1. 1 Hebei Eye Hospital, Provincial Key Laboratory of Ophthalmology, Hebei Provincial Clinical Research Center for Eye Diseases, Xingtai Hebei 054001, China; 2 Department of Ophthalmology Teaching and Researching, Hebei Medical University, Shijiazhuang 050017, China; 3 Department of Ophthalmology, School of Clinical Medicine, North China University of Science and Technology, Tangshan Hebei 063210, China
  • Received:2026-01-26 Online:2026-09-25 Published:2026-09-18
  • Contact: Zhang Yue, Email: zhangyueyk@163.com
  • Supported by:
    Key R&D Plan Self Funded Project of Xingtai City (2023ZC175); Central Guiding Local Science and Technology Development Fund Project (Basic Research Project) (264Z7766G)

摘要:  目的 探讨白内障超声乳化术中联合后囊膜连续环形撕囊(posterior continuous curvilinear capsulorhexis,PCCC)对术后黄斑区脉络膜毛细血管血流密度(choriocapillaris flow density,CFD)及黄斑中心凹视网膜厚度(central macular thickness,CMT)的影响。设计 前瞻性比较性病例系列。研究对象 施行白内障超声乳化术的年龄相关性白内障患者100例(100眼)。方法 根据白内障超声乳化术中后囊膜情况,将抛光无法去除后囊混浊者纳入PCCC组(50眼),将后囊混浊可去除或无混浊者纳入对照组(50眼)。所有患者均于术前及术后1天、1周、1个月、3个月接受相干光断层扫描血管成像(optical coherence tomography angiography,OCTA)检查。主要指标 黄斑区CFD和CMT。结果  PCCC组术后1个月及3个月的CFD均显著低于对照组(术后1个月:59.18% ± 3.00% 、 61.28% ± 2.86%,P<0.001;术后3个月:60.24%±3.29%、62.98%±2.63%,P<0.001),且PCCC组术后1个月的CMT显著高于对照组(267.58±15.66 μm、255.80±15.90 μm,P<0.001)。相关性分析显示,PCCC组术后1个月CFD与CMT呈显著负相关(r=-0.319,P=0.024)。多元线性回归分析显示,是否采用PCCC是术后CMT变化值的独立影响因素(β=-8.071,P=0.006)。两组患者均无临床意义的黄斑水肿发生。结论 年龄相关性白内障患者PCCC可导致术后早期黄斑区CFD轻微下降和CMT轻度增加,但这种一过性解剖学改变主要为亚临床水平的改变。年龄相关性白内障患者PCCC手术具有良好的短期安全性。

关键词: 后囊膜连续环形撕囊术, 相干光断层扫描血管成像, 脉络膜毛细血管血流密度, 黄斑中心区视网膜厚度

Abstract:  Objective To investigate the effect of primary posterior continuous curvilinear capsulorhexis (PCCC) combined with phacoemulsification on postoperative choriocapillaris flow density (CFD) and central macular thickness (CMT) in the macular region. Design Prospective comparative case series. Participants A total of 100 patients (100 eyes) with age-related cataract who underwent phacoemulsification surgery. Methods Based on the intraoperative status of the posterior capsule during phacoemulsification, patients in whom polishing failed to remove posterior capsule opacification were assigned to the PCCC group (50 eyes), while those with removable posterior capsule opacification or without opacification were assigned to the control group (50 eyes). All patients underwent optical coherence tomography angiography (OCTA) examination preoperatively and on 1 day, 1 week, 1 month, and 3 months postoperatively. Main Outcome Measures Macular CFD and CMT. Results The CFD in the PCCC group was significantly lower than that in the control group at both 1 month and 3 months postoperatively (1 month: 59.18%±3.00% vs. 61.28%±2.86%, P<0.001; 3 months: 60.24%±3.29% vs. 62.98%±2.63%, P<0.001), and the CMT at 1 month postoperatively was significantly higher in the PCCC group than in the control group (267.58±15.66 μm vs. 255.80±15.90 μm, P<0.001). Correlation analysis revealed a significant negative correlation between CFD and CMT at 1 month postoperatively in the PCCC group (r=-0.319, P=0.024). Multiple linear regression analysis showed that the application of PCCC was an independent influencing factor for the change in postoperative CMT (β=-8.071, P=0.006). No clinically significant macular edema occurred in either group. Conclusion PCCC in patients with age-related cataract may lead to a slight decrease in macular CFD and a mild increase in CMT during the early postoperative period. However, these transient anatomical changes are primarily subclinical in nature. PCCC surgery demonstrates favorable short-term safety in patients with age-related cataract.

Key words: Primary posterior continuous curvilinear capsulorhexis, Optical coherence tomography angiography, Choriocapillaris flow density, Central macular thickness