眼科 ›› 2026, Vol. 35 ›› Issue (1): 9-17.doi: 10.13281/j.cnki.issn.1004-4469.2026.01.002

• 专家讲座 • 上一篇    下一篇

微孢子虫角膜炎的诊断与治疗

孙旭光   

  1. 首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科研究所 眼科学与视觉科学北京市重点实验室,北京 100730
  • 收稿日期:2025-09-25 出版日期:2026-01-25 发布日期:2026-01-13
  • 通讯作者: Email:sunxg1955@163.com E-mail:sunxg1955@163.com

Diagnosis and management of microsporidial keratitis

Sun Xuguang   

  1. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100730, China
  • Received:2025-09-25 Online:2026-01-25 Published:2026-01-13
  • Contact: Email:sunxg1955@163.com E-mail:sunxg1955@163.com

摘要: 近年来,国外报道的微孢子虫角膜炎病例数不断增多,国内多个眼科机构也已有报道和确诊病例。微孢子虫为单细胞、专性细胞内寄生的原虫,主要通过接触感染角膜,由于其临床表现与常见的浅层点状角膜炎或真菌性角膜炎相似,因此其确诊主要依靠病原学的实验室检查。目前微孢子虫角膜炎主要依靠伏立康唑等抗真菌药物和加替沙星等抗生素药物联合治疗,严重的角膜基质炎患者需要及时手术治疗。微孢子虫角膜炎的病原学、病理机制、快速诊断方法以及治疗方法仍需进一步研究。

关键词: 微孢子虫, 角膜炎, 角结膜炎, 寄生虫

Abstract: In recent years, the number of cases of microsporidial keratitis reported abroad has been increasing and many domestic ophthalmic institutions have also reported and diagnosed such cases. Microsporidia is a unicellular, intracellular parasitic protozoa, which mainly infects the cornea through contact contamination. Because its clinical manifestations are similar to common superficial punctate keratitis or fungal keratitis, its diagnosis mainly depends on laboratory examination of etiology. At present, the treatment of microsporidia cornea mainly depends on the combination of antifungal drugs such as voriconazole and antibiotics such as gatifloxacin, and patients with severe corneal stromitis need timely surgical treatment. The etiology, pathological mechanism, rapid diagnosis and treatment of microsporidia keratitis need further study.

Key words: Microsporidia, Keratitis, Keratoconjunctivitis, Parasite