Abstract:  Objective To investigate the difference of the refraction between patients with exudative age-related macular degeneration (AMD) and non-AMD populations. Design Case-control study. Participants A total of 247 eyes with refraction information from 136 exduative AMD patients were recruited. 154 eyes with AMD as exduative AMD group, in which 67 eyes were from 34 biocular AMD patients, 87 eyes were from 102 monocular AMD patients. A number of 242 non-AMD eyes (136 non-AMD subjects who were age and sex matched with the AMD group) were recuited from Beijing Desheng Region as control group. Methods Refractions were measured by auto refractor and non mydriatic optometry. Hyperopia standard defined as more than +0.5 D. The refractions were compared between the two groups. Main Outcome Measures Refraction state and degree. Results The frequencies of hyperopia in AMD group were 46.7% (72 eyes), the refractions of interquartile range was +0.50（-0.38，+1.25）D. The frequencies of hyperopia were 30.6% (74 eyes) in control group, meanwhile the refractions of interquartile range was +0.13（-1.13，+0.84）D. The refractions of AMD group were inclined to higher hyperopia than control group（P<0.001）. Also, there were higher hyperopia frequencies of AMD group than control group（P<0.001）. Conclusion Compared with non-AMD populations, exudative AMD patients may be inclined to be a higher hyperopia. (Ophthalmol CHN, 2014, 23: 99-102)

Key words: age-related macular degeneration, refraction, hyperopia