Abstract: Objective To evaluate the efficacy and safety of ab externo microcatheter-assisted trabeculotomy(MAT) for the surgical management of juvenile open angle glaucoma(JOAG) and primary open angle glaucoma(POAG). Design Retrospective case series. Participants Consecutive 22 patients (26 eyes) with JOAG with mean age 25.2±4.5 years old and 11patients (14 eyes) with POAG with mean age 46.3± 5.1 years old underwent ab externo MAT between November 2017 and December 2018 by a single surgeon in Beijing Tongren Eye Center. Methods The patient's medical records were reviewed. Patients were followed before and 1, 3, 6, 12 months after surgery. Surgical success was defined as a postoperative IOP of ≤21 mmHg and decreased more than 20% from baseline without the use of anti-glaucoma medication. Main Outcome Measures  Intraocular pressure (IOP), number of anti-glaucoma medication, surgical complications. Results All cases fulfilled 12 months follow-up. The mean age of JOAG group was 25.2±4.5 years old, the mean age of POAG group was 46.3±5.1 years old. The preoperative IOP was 30.6±7.5 mmHg in JOAG group, which was much higher than that in POAG group (25.4±6.2 mmHg, P=0.035). The overall IOP reduction was 44.9±18.0% from 30.6±7.5 mmHg to 15.8±3.3 mmHg at 12 months in JOAG group (P<0.01). For POAG group, the IOP reduction was 35.8±15.6% from 25.4±6.2 mmHg to 15.9±3.2 mmHg at 12 months in POAG group (P<0.01). The number of topical medication decreased dramatically after surgical procedures in both groups (P<0.01). The overall complete success rate was similar between the two groups, 76.0% for JOAG and 78.6% for POAG (P=0.855). There was no severe complications occurred in both groups. Conclusion Ab externo MAT is same effective and safe surgical option both JOAG and POAG. (Ophthalmol CHN, 2021, 30: 20-24)

Key words: ab externo microcatheter-assisted trabeculotomy, juvenile open angle glaucoma, primary open angle glaucoma