Table of Content

22 January 2021, Volume 30 Issue 1

Previous Issue   

To comprehend the role of micropulse laser in diabetic macular edema treatment

Li Yibin

2021, 30(1):  1-4.  doi:10.13281/j.cnki.issn.1004-4469.2021.01.001

Asbtract ( 758 )   PDF (546KB) ( 6029 )  

Related Articles | Metrics

Micropulse laser photocoagulation is a laser photocoagulation paradigm which can minimize retinal laser injury so as to selectively treat certain retinal layers by delivering the laser energy with a train of repetitive extremely short pulses within an emission instead of one conventional continuous longer pulse. Studies have shown that micropulse laser photocoagulation has the same effect on maintaining visual acuity as conventional laser photocoagulation in the treatment of diabetic macular edema (DME). High density / low intensity micropulse laser photocoagulation can be effective for the DME treatment without any detectable laser damage to the neuroretina. The rationale of micropulse laser photocoagulation for DME treatment may be some specific light-induced effects of the laser on the neuroretina, resulting in series changes of the bioactive factors expression. There are disagreements in clinical application of micropulse laser photocoagulation: whether the power needs to be titrated and whether the fovea can be covered during the treatment. It should be suggested to titrate the laser power in order to achieve idea treatment, and it should not be overemphasized to cover the fovea during treatment in order to avoid disastrous consequences resulted by incorrect power titration. (Ophthalmol CHN, 2021, 30: 1-4)

New insights into immune mechanisms in primary open angle glaucoma 

Yang Xue, Yu Xiaowei, Fan Zhigang

2021, 30(1):  5-10.  doi:10.13281/j.cnki.issn.1004-4469.2021.01.002

Asbtract ( 393 )   PDF (1204KB) ( 5999 )  

Related Articles | Metrics

Investigation into mechanisms that are independent of IOP, but cause initial or secondary damages to retinal ganglion cells and/or their axons is imperative. The retina is a part of the central nervous system (CNS). POAG and other neurodegenerative diseases may share some common pathological mechanisms, of which the neuroimmunity-inflammation plays a pivotal role. State-of-the-art findings on immune mechanisms of CNS neurodegeneration may shed some novel insight into the exploration of POAG pathogenesis. From a perspective of neuroscience and immunology, focusing on microglia and T lymphocytes in light of the latest findings in immune mechanisms of neurodegeneration, we have therefore established a novel theoretical structure integrating existing knowledge on the pathogenesis of POAG. Altogether, we speculate that mechanisms of POAG immune injury is as follows: neuron damage-associated antigens activate microglia releasing pro-inflammatory factors and increasing the adhesion of peripheral circulating leukocytes, and thereafter the permeability of BRB changes; the antigen presentation process may be achieved through diverse pathways; in lymphoid organs, T cells clone, proliferate and differentiate induced by the interaction with APCs, and then antigen-specific T cells enter the retina through the BRB, causing the exacerbation of immune-inflammatory damage to retinal neurons. (Ophthalmol CHN, 2021, 30: 5-10)

Five years’ results of LPI on acute primary angle closure glaucoma and PAS extent influence evaluation

Li Sizhen, Guo Chunyu, Liang Yuanbo, Fan Sujie, Cai Xiaogu, Sun Xia, Guo Lixia, Sun Lanping, SUCIJANTI, Han Wei, Wang Ningli

2021, 30(1):  11-19.  doi:10.13281/j.cnki.issn.1004-4469.2021.01.003

Asbtract ( 878 )  

Related Articles | Metrics

Objective To investigate the intraocular pressure(IOP) control rate and the influence of peripheral anterior synechia (PAS) extent on acute primary angle closure glaucoma (APACG) patients receiving laser peripheral iridotomy (LPI) 5 years before.  Design Prospective cohort study. Participants Consecutive 182 cases of APACG patients with acute attack from 10/2005 to 10/2006 in Handan Eye Hospital were recruited and received “Sequential Treatment, ST”. Methods Laser peripheral iridotomy (LPI) were firstly used after initial treatment of onset of APACG. The APACGs whose IOP≤21 mmHg after LPI were followed up and those IOP>21 mmHg were treated with topical anti-glaucoma drugs. If the IOPs were remaining beyond 21 mmHg with the additional drugs, trabeculectomy would be performed to decrease the IOPs. All patients would be followed up for five years. Main outcome Measures IOP and PAS extent.  Results 124 APACG patients with age 68.3±7.3 years and female 105 cases (84.7%) were finished 5 years follow up. Total IOP control rate (≤21 mmHg) was 90.3 %( 112/124). IOP control rate of LPI was 68.5 %( 85/124). IOP control rate of LPI combined drugs was 81.4 %( 101/24). Rate of trabeculectomy was 12.1%(15/124). IOP control rate of LPI in five groups PAS 0, PAS 1-3, PAS 4-6, PAS 7-9, PAS 10-12 was 92.6%, 74.3%, 84.2%, 56.3%, 40.0% respectively, and IOP control rate of LPI combined drugs in groups was 96.3%, 91.4%, 89.5%, 68.8%, 55% respectively. Trabeculectomy rate of those groups was 0%, 5.7%, 5.3%, 18.8%, 35% respectively. As the PAS extent increased, the IOP control rates of LPI or LPI combining drugs decreased but trabeculectomy rates increased. The IOP control rate of LPI or LPI combining drugs in PAS≤6 o’clock (180 degree) group was 82.72% (67/81), 92.59%(75/81) higher than those 47.22%(17/36), 61.11% (22/36) in PAS>6 o’clock group (P<0.001). Trabeculectomy rates of PAS≤6 o’clock group (3.7%) was lower than PAS >6 o’clock group (27.7%) (P<0.001). Conclusions Sequential treatment has a high total IOP control rate ( 90.3%) for APACG. As the PAS extent increased, the IOP control rate of LPI and LPI combining drugs decreased, however the filtration rate increased. If APACG in PAS>6 o’clock group received filtration surgeries based on Chinese PACG treatment guideline, that would lead to a higher filtration surgical rate.  (Ophthalmol CHN, 2021, 30: 11-19)

Comparison of the efficacy and safety of ab externo microcatheter-assisted trabeculotomy for juvenile open-angle glaucoma and primary open angle glaucoma 

Wang Huaizhou, Xin Chen, Shi Yan, Li Meng, Wang Ningli

2021, 30(1):  20-24.  doi:10.13281/j.cnki.issn.1004-4469.2021.01.004

Asbtract ( 456 )   PDF (1251KB) ( 6028 )  

Related Articles | Metrics

Objective To evaluate the efficacy and safety of ab externo microcatheter-assisted trabeculotomy(MAT) for the surgical management of juvenile open angle glaucoma(JOAG) and primary open angle glaucoma(POAG). Design Retrospective case series. Participants Consecutive 22 patients (26 eyes) with JOAG with mean age 25.2±4.5 years old and 11patients (14 eyes) with POAG with mean age 46.3± 5.1 years old underwent ab externo MAT between November 2017 and December 2018 by a single surgeon in Beijing Tongren Eye Center. Methods The patient's medical records were reviewed. Patients were followed before and 1, 3, 6, 12 months after surgery. Surgical success was defined as a postoperative IOP of ≤21 mmHg and decreased more than 20% from baseline without the use of anti-glaucoma medication. Main Outcome Measures  Intraocular pressure (IOP), number of anti-glaucoma medication, surgical complications. Results All cases fulfilled 12 months follow-up. The mean age of JOAG group was 25.2±4.5 years old, the mean age of POAG group was 46.3±5.1 years old. The preoperative IOP was 30.6±7.5 mmHg in JOAG group, which was much higher than that in POAG group (25.4±6.2 mmHg, P=0.035). The overall IOP reduction was 44.9±18.0% from 30.6±7.5 mmHg to 15.8±3.3 mmHg at 12 months in JOAG group (P<0.01). For POAG group, the IOP reduction was 35.8±15.6% from 25.4±6.2 mmHg to 15.9±3.2 mmHg at 12 months in POAG group (P<0.01). The number of topical medication decreased dramatically after surgical procedures in both groups (P<0.01). The overall complete success rate was similar between the two groups, 76.0% for JOAG and 78.6% for POAG (P=0.855). There was no severe complications occurred in both groups. Conclusion Ab externo MAT is same effective and safe surgical option both JOAG and POAG. (Ophthalmol CHN, 2021, 30: 20-24)

Application of soft separation on the early bleb encapsulation separation after Ahmed glaucoma valve implantation

Wang Rujie, Pan Weihua

2021, 30(1):  25-29.  doi:10.13281/j.cnki.issn.1004-4469.2021.01.005

Asbtract ( 371 )   PDF (730KB) ( 6035 )  

Related Articles | Metrics

Objective  To investigate the efficacy and safety of combined viscoelastic and antimetabolites injection in the early bleb encapsulation after Ahmed glaucoma valve implantation. Design Retrospective case series. Participarts Seventy nine (84 eyes) patients with glaucoma who underwent Ahmed glaucoma valve implantation in The Eye Hospital of WMU at Zhijiang from April 2018 to September 2019 were included. Methods Injection was performed under the slitlamp. A needle was inserted into to the bleb through the incision 2 mm behind the middle point of the two fixative sutures between the plate and sclera. The viscoelastic agent with 0.4 ml volume was injected into the bleb and was pushed backwards. Thereafter, antimetabolite agent of 5-fluorouracil or MMC was subconjunctivally injected around the drainage plate. If intraocular pressure < 21mmHg, complete success was defined as not using glaucoma drugs. Main Outcome Measures The time of intraocular pressure ≥ 21 mmHg, intraocular pressure at the time of encapsulation, Intraocular pressure at the followed up point after injection, anterior chamber depth after injection, injection times, types of glaucoma drugs used. Results Eighty four eyes underwent AGV implantation, 48 (57.14%) eyes occurred intraocular pressures elevation after surgery. The mean duration of elevation was 24.6±14.5 days. Viscoelastic agents alone or combined with antimetabolites (5-FU or MMC) were injected in 48 eyes. Three months after injection, 14 eyes (38.9%) were complete success and 36 eyes (75%) were modified success respectively. There were 15 eyes (31.25%) with transient shallow anterior chamber and 5 eyes (10.41%) with anterior chamber disappearing. Multiple factor analysis showed that the intraocular pressure at the time of early encapsulation after glaucoma valve surgery was a factor influencing the effectiveness of soft separation (P=0.026). Conclusion Soft separation by viscoelastic agents in combination with antimetabolites is safe and effective to separate early encapsulated bleb after Ahmed valve implantation. (Ophthalmol CHN, 2021, 30: 25-29)

Preliminary reports of low dose trans-scleral cycloplasty in acute angle closure glaucoma

Lin Haishuang, Ye Cong, Huang Qiangjie, Wang Xiaojie, Zhou Wenzhe, Zhang Shaodan, XieYanqian, Xu Shuxia, Le Rongrong, Liang Yuanbo

2021, 30(1):  30-35.  doi:10.13281/j.cnki.issn.1004-4469.2021.01.006

Asbtract ( 453 )   PDF (1776KB) ( 6099 )  

Related Articles | Metrics

Objective To evaluate the short-term changes of anterior chamber depth and angle parameters in acute angle closure glaucoma underwent low dose trans-scleral cycloplasty (LDCP). Design Prospective case series. Participants 15 eyes from 12 patients were diagnosis as cute angle closure glaucoma patients with sudden attack at the Eye Hospital of Wenzhou Medical University from May 2018 to November 2019. Methods LDCP is a treatment adopting few laser points (1200~2000 mW energy, 2 seconds duration) that burns the ciliary body over two hour-positions to shrink ciliary body and release ciliary block.  Acute angle closure glaucoma patients underwent low dose trans-scleral cycloplasty (LDCP). The mean age was (54.7±14.1) years old (22~72 years old), including 5 males and 7 females. Data before LDCP and one week, one month, three months after LDCP were collected. Main Outcome Measures Intraocular pressure, central anterior chamber depth, angle opening distance 500 (AOD500), trabecular-iris angle 500 (TIA500), maximum ciliary body thickness (CBTmax), trabecular-ciliary angle (TCA) and number of medications. Results The mean number of laser burns was (13.3±2.3) (9~16). The median preoperative IOP (range) was 26.6 (7.3~60.0) mmHg  with the median medication number of 3 (0~5). The median postoperative IOP was 10.6(6.1~53.9) mmHg (Z=-2.726, P=0.006) with the median medication number of 0 (0~3) (Z=-3.078, P=0.002). The central anterior chamber depth measured by ultrasound biomicroscopy (UBM) was increased from (1.44±0.48) mm preoperatively to (1.66±0.34) mm postoperatively, respectively (t=-2.783, P=0.015). And the AOD500 and TIA500 values measured by UBM had a significant difference between preoperative and postoperative (all P<0.05). The CBTmax and TCA values measured increased from preoperation topostoperation (CBTmax: P=0.060；TCA: P=0.004). The deepen of peripheral anterior chamber was observed by van Herick technique respectively in thirteen eyes (86.7%). 8 eyes underwent cataract surgery for different reasons within one month after LDCP. Among 7 eyes without secondary surgery, the median IOP was 15.5 mmHg and mean anterior chamber depth was 1.73 mm three months after LDCP. Conclusion Preliminary study shows that LDCP can significantly deepen the central and peripheral anterior chamber of acute angle closure glaucoma and reduce the intraocular pressure quickly, which provides a new idea for the treatment of angle closure glaucoma in acute phase. However, the safety of this treatment needs to be further observed. (Ophthalmol CHN, 2021, 30: 30-35)

nalysis of ocular biometry in patients with congenital cataract in Northern China

Li Meng, Wang Jinda, Zhang Jingshang, Wang Kaijie, Mao Yingyan, Chen Shuying, Yao Qinnan, Wan Xiuhua

2021, 30(1):  36-41.  doi:10.13281/j.cnki.issn.1004-4469.2021.01.007

Asbtract ( 649 )  

Related Articles | Metrics

Objective To investigate the biometry data of eyes with congenital cataract (CC) in North China. Design Retrospective case series. Participants 117 CC patients under 18 years old in Beijing Tongren Hospital from 2010 to 2018. Methods The medical records of CC patients were reviewed. All patients underwent A-scan, keratometry examination or IOL-Master 500 examination. CC patients were grouped according to their age (1~24 months, 25~72 months, and 73~216 months), gender (male or female) and whether both eyes were affected (monocular or binocular), and the ocular biometrics between different groups were compared. For patients with monocular CC, the differences between cataract eyes and contralateral eyes were also analyzed.  Main Outcome Measures axial length, keratometry and corneal astigmatism. Results The average axial length, keratometry and corneal astigmatism of 117 CC patients were 21.92±1.76 mm, 43.78±1.81 D, and 2.03±1.10 D respectively. The axial length of CC patients in 1~24 months group, 25~72 months group and 73~216 months group were 20.59±1.31 mm, 22.00±1.70 mm and 22.60±1.65 mm respectively (F=11.99, P<0.001). There was no significant difference in keratometry and corneal astigmatism among different age groups (F=0.330, P=0.720 and F=0.625, P=0.537). There was no significant difference in axial length and keratometry between different gender groups (t=-1.862, P=0.065 and t=1.709, P=0.090). There was no difference in axial length and keratometry between monocular and binocular CC patients (t=1.272, P=0.206 and t=-0.145, P=0.885). There was no significant difference in axial length and keratometry between cataract eyes and contralateral eyes in monocular CC patients (t=-0.624, P=0.536 and t=-0.201, P=0.842), but the corneal astigmatism of cataract eyes was larger (2.05±1.00 D vs 1.38±0.83 D, P<0.001). Conclusion CC may defer the physiological decrease of corneal astigmatism. The axial length of CC patients increased rapidly before 2 years old, and slowly after 2 years old, which provided a reference for the selection of appropriate time for intraocular lens implantation in CC patients. (Ophthalmol CHN, 2021, 30: 36-41)

Analysis of prognostic factors in patients with high myopia combined with choroidal detachment retinal detachment 

Jia Liyun, Zhang Yongpeng, Zhou Haiying, She Haicheng, Cao Xusheng, Gao Liqin, Ma Kai

2021, 30(1):  42-46.  doi:10.13281/j.cnki.issn.1004-4469.2021.01.008

Asbtract ( 551 )  

Related Articles | Metrics

Objective To analyze the prognostic factors in patients with high myopia (HM) combined with choroidal detachment retinal detachment(RRD-CD). Design Retrospective case series. Participants 836 patients with HM and RRD-CD of Beijing Tongren Hospital from 2004 to 2018. Methods A retrospective chart review was carried out on all patients with HM and RRD-CD having surgical treatment. Recurrence rate was calculated and risk factors of recurrence RRD were analyzed using Logistic regression analysis. Main Outcome Measures Operation success rate, risk factors of recurrence RRD. Results A total of 836 patients with HM complicated with RRD-CD were included, with an average age of 56.51±12.14 years; 518 cases (61.9%) were male, 434 cases (51.9%) had right eye disease, and 22.7% had retinal detachment without reattachment. Compared with the patients with retinal reattachment, the age of patients without reattachment was younger, and the differences in preoperative visual acuity, axial length, lens state, retinal hole, PVR grade and operation method were statistically significant. Age [odds ratio (OR)=0.972, 95% confidence interval (95% CI), 0.967-0.989], preoperative visual acuity (OR=1.898, 95% CI: 1.297-2.777), intraocular lens (OR=1.860, 95% CI: 1.255-2.758), axial length more than 30 mm (OR=1.718, 95% CI: 1.240-2.379), giant retinal hole (OR=2.464, 95% CI: 1.495-4.063) and PVR Grade D (OR=1.551, 95% CI: 1.046-2.300) was the risk factor for retinal detachment without reattachment. Conclusions High myopia patients with RRD-CD have a large proportion of males. Middle aged patients with ultra-high myopia, intraocular lens, giant retinal hole and PVD grade D have low success rate of the first operation, and retinal detachment is easy to relapse. (Ophthalmol CHN, 2021, 30: 42-46)

Surgical treatment of lower eyelid retraction combined with exophthalmos in children

Cao Wenhong, Fan Yunwei, Wang Yuan, Liu Wen, Li Cheng, Li Li, Wu Qian

2021, 30(1):  47-50.  doi:10.13281/j.cnki.issn.1004-4469.2021.01.009

Asbtract ( 346 )  

Related Articles | Metrics

Objective To investigate the efficacy of surgical treatment on entropion combined with exophthalmos in children． Design Retrospective case series． Participants 14 eyes of 8 children with entropion due to exophthalmos were analyzed retrospectively, who were 1.2-8.3 years old, in Beijing Children’s Hospital. Methods The surgical treatment was the lower lid retractor recession combined meibomian internal fixation suture. The follow-up time was 6 to 12 months. Main Outcome Measures The margin reflex distances 2 (MRD2) was measured and the effect after surgery was observed． Results In 8 cases, the symptoms of shyness and tears were relieved, the eyelids closed well, the lower eyelid margin did not show obvious entropion and trichiasis, and the corneal epithelium was repaired after surgery. There was significant difference in MRD2 before and after operation, which were 6.3±0.5 mm and 4.3±0.8 mm in average (t=7.772, P<0.01). Conclusion This small sample size retrospective study shows that the lower lid retractor recession combined meibomian internal fixation suture fundamentally solves the problems of eyelid tension, lower eyelid retraction, entropion and trichiasis caused by exophthalmos, reduces the recurrence of operation, and achieves satisfactory results. (Ophthalmol CHN, 2021, 30: 47-50)

Clinicopathological features of orbital intravascular papillary endothelial hyperplasia

Wang Yuchuan, Chen Luxia, Li Jing, Lin Jinyong

2021, 30(1):  51-55.  doi:10.13281/j.cnki.issn.1004-4469.2021.01.010

Asbtract ( 686 )  

Related Articles | Metrics

Objective To describe the clinicopathological features of orbital intravascular papillary endothelial hyperplasia (IPEH). Design Retrospective case series. Participants Nine cases of orbital IPEH retrospectively reviewed in Tianjin Eye Hospital in 2006–2019. Methods The clinical and pathological features were reviewed. The clinical data were evaluated for patient age, gender, clinical history, clinical features, Grayscale and color Doppler ultrasound, CT and MRI. Main Outcome Measures Pathological data, including gross presentation, tumor size, histopathological and immunohistochemical features were also reviewed. Results The study group included 7 females and 2 males. The average age at diagnosis was 46.8±11.0 years. The duration of symptoms before seeing an ophthalmologist was less than 2 months in most cases (7/9)，and the most common symptoms were proptosis (9/9) and decreased eye motility (3/9). Grayscale and color Doppler US examinations showed an oval or round lesion with homogeneous echogenicity. No detectable vessels were found inside tumors by color Doppler US examinations. CT scanning (all 9 cases) revealed a well-circumscribed mass with homogeneous soft tissue density. Most lesions (8/9) located in retrobulbar muscle cone, however one case was extraconal. MRI (3 cases) showed isointense T1 signal and hyperintense T2 signal. The appearance of the tumor was gray-purple or gray-yellow, the capsule was intact, and there was no obvious adhesion to the surrounding tissues. The diameter of tumors was 10~20 mm. Photomicrograph showed the multiple small papillary projections lined by a single layer of plump endothelial cells and supported by fibrous connective tissue core, and multiple vascular channels. The endothelial cells were positive for CD31 and CD34. At the follow-up, 8 cases had no recurrence, and only 1 case recurred after 7 years of surgical excision. Conclusion Orbital IPEH was a very rare vascular lesion, which often occurred in the muscle cone of the adult orbit. The tumor was single, the boundary is clear, and there was little recurrence after surgical excision. (Ophthalmol CHN, 2021, 30: 51-55)

Analysis of the clinical features of orbital apex syndrome induced by non-specific inflammation

Zhang Jing, Wang Lian, Jiang Libin

2021, 30(1):  56-61.  doi:10.13281/j.cnki.issn.1004-4469.2021.01.011

Asbtract ( 559 )  

Related Articles | Metrics

Objective To investigate the clinical characteristics of a group of cases with orbital apex syndrome caused by non-specific inflammation. Design Retrospective case series. Participants 15 patients(16 eyes) with orbital apex syndrome caused by non-specific inflammation of orbital apex in Beijing Tongren Hospital and Beijing Puren Hospital from June 2016 to May 2019. Methods The clinical symptoms, physical signs, ophthalmic imaging, laboratory examination, hormone treatment effect and prognosis were reviewed. Main Outcome Measures The clinical symptoms and signs, orbital and head CT, MRI image features. Results Of the 15 patients, 8 were male, with an average age of (53±16) years. 14/15 patients were attacked by monocular. The lesion of all cases was confined to the orbital apex, 7 of which were both involved in the cavernous sinus. Periorbital pain occurred in the eyebrow arch or radiated to the zygomatic temporal part, orbital apex syndrome gradually appeared after the pain. The irregular solid lesions of orbital apex in orbital MRI showed equal T1WI and equalT2WI signals, which could be enhanced uniformly. The patients who were finally diagnosed as non-specific orbital inflammation were treated with systemic and /or ocular local hormone treatment. The symptoms of 15 patients were totally relieved, the periorbit pain of 14 eyes (87.5%) were completely disappeared. The blepharoptosis of 13 eyes (81.3%) were relieved, and ocular movement and diplopia of 11 eyes (68.8%) were improved. All the lesions in orbital MRI shrinked after 3 months hormone treatment. The recovery of visual function, however, was unsatisfactory. The vision of 8 eyes (50%) had no improvement, 2 eyes (12.5%) relapsed during the period of follow-up. Conclusion The orbital apex syndrome induced by non-specific inflammation is characterized by local ocular pain and oculomotor disturbance in early stage, and then the visual impairment happened quickly. Clinical manifestations and neuroimaging examination are the main diagnostic basis. Systemic and/or local hormone therapy can effectively improve eye movement disorders and pain. But the recovery of visual acuity is difficult and the recurrence is possible. (Ophthalmol CHN, 2021, 30: 56-61)

Influencing factors of binocular vision reconstruction in postoperative orthophoric children with intermittent exotropia

Lin Nan, Wang Jinghui, Sun Shengli, Dong Fang

2021, 30(1):  62-65.  doi:10.13281/j.cnki.issn.1004-4469.2021.01.012

Asbtract ( 373 )  

Related Articles | Metrics

Objective To analyze the binocular visual function reconstruction and its influencing factors in postoperative orthophoric children with intermittent exotropia. Design Retrospective case series. Participants 414 postoperative orthophoric children with intermittent exotropia in Beijing Tongren Hospital from 2009 to 2019. Methods The binocular vision of 414 children was detected with synoptophore and the stereogram designed by Yan Shao-ming before and after surgery. The patients were divided into several groups separately according to the binocular vision detected by synoptophore before surgery, the age of onset, the age of surgery and the maximum distant deviation. Binocular vision reconstruction refers to the establishment of normal binocular vision after strabismus treatment. Main Outcome Measures The binocular vision detected with synoptophore and the near stereoacuity. Results There was no statistical difference in the near stereoacuity before and after surgery (χ2=0.999，P=0.382). The reconstruction of binocular vision in the group with distant stereoacuity before surgery was the best (χ2=49.929，P=0.000). In terms of the age of onset, the preoperative distant binocular vision of 0~3 years old group was significantly worse than that of 4~8 years old and 9~12 years old groups (χ2=18.592，P=0.006). There was no significant difference in the distant and near binocular vision after surgery among the three age groups (all P>0.05). In terms of the age of surgery, the preoperative distant binocular vision of 9~13 years old group was better than that of 3~4 years old and 5~8 years old groups (χ2=16.586，P=0.011). There was no significant difference in the distant and near binocular vision after surgery among the three age groups (all P>0.05). In terms of the maximum distant deviation, the preoperative and postoperative distant binocular vision of small deviation group was significantly better than that of medium and large deviation groups (all P＜0.05). There was no significant difference in the near stereoacuity before and after surgery among the three deviation groups (all P>0.05). Conclusion Whether there is distant stereoacuity before surgery is an important factor of the binocular vision reconstruction. The earlier age of onset, the greater deviation, the more serious damage to the distant binocular vision was. （Ophthalmol CHN, 2021, 30: 62-65）