Abstract: The position of the lens plays an important role in the pathogenesis of primary angle-closure disease (PACD). Abnormal of zonular fibers and subsequent lens dislocation can affecting lens size and shape, cause the anterior chamber to become shallow or unstable. Factors such as aging, genetics, trauma and inflammation may affect the structure and function of the zonule and lead to angle-closure glaucoma. Studying the zonule in PACD helps us understand some clinical phenomena such as why myopia is not uncommon in patients with angle-closure; sometimes, the anterior chamber may become shallower and in turn, the aqueous misdirection or malignant glaucoma may occur after using pilocarpine for PACD; younger PACD may often have systemic genetic disease, etc. But at present there is no simple and accurate methods to assess the zonule at preoperation or intraoperation. (Ophthalmol CHN, 2022, 31: 169-174)

Key words: lens zonule, angle-closure glaucoma