Abstract:  Objective To evaluate the efficacy and safety of endoscopic-assisted transluminal trabeculotomy (EATT) and microcatheter-assisted trabeculotomy (MAT) in the treatment of primary congenital glaucoma (PCG). Design Retrospective case series. Participants Consecutive 16 patients (20 eyes) with PCG underwent EATT and 17 patients (21 eyes) with PCG underwent MAT in the  Xuzhou First People's Hospital from January 2020 to October 2021. The mean age of EATT group and MAT group was (40.4±26.9) months and (38.3±29.0) months, respectively. Method The medical records of the patients before operation and 1, 3, 6, 9, 12 months after operation were reviewed. Intraocular pressure (IOP), numbers of anti-glaucoma medication, the rate of surgical success and postoperative complications were recorded. Success was defined as IOP<21 mmHg with (qualified success) or without (absolute success) the use of anti-glaucoma medication. Main Outcome Measures IOP, numbers of anti-glaucoma medication, the rate of absolute success and qualified success, postoperative complications. Results All cases were followed up for≥6 months. In EATT group, the IOP at 12 months postoperatively was lower than that before operation, which was (15.8±3.1) mmHg and (36.3±7.0) mmHg respectively (Z=-3.408，P=0.001）. In MAT group, the IOP at 12 months postoperatively were lower than that before operation too, which was (17.2±3.7) mmHg and (35.5±6.2) respectively（Z=-3.519，P＜0.001）. In both groups, the IOP and numbers of anti-glaucoma medication were significantly decreased at all time points of the follow-up periods compared to the preoperative values (all P<0.01). There was no statistical significance in IOP between the two groups (all P>0.05). At 12 months postoperatively, the absolute success rates were 71.4% in EATT group and 68.8% in MAT group, and the qualified success rates were 85.7% in EATT group and 81.3% in MAT group. There were no statistical significance between the two groups (P=0.888, 0.748). There were no significant differences in the incidence of anterior chamber hemorrhage and transient intraocular hypertension between the two groups （χ2=1.003，0.344，P=0.317，0.558）. There were no severe complications such as cataract, intraocular infection, retinal detachment and ocular atrophy in both groups. Conclusions There was no significant difference in efficacy and safety between EATT and MAT in the treatment of PCG. EATT provides a minimally invasive surgical option for PCG with corneal opacity. (Ophthalmol CHN, 2022, 31: 334-339)

Key words: endoscopic-assisted transluminal trabeculotomy, microcatheter-assisted trabeculotomy, primary congenital glaucoma