Abstract: Objective To analyze the characteristics of ocular biological parameters of cataract patients with long axial lengths (AL) . Design Retrospective cases series. Participants From June 2021 to April 2022, 1000 cataract patients (1000 eyes) who received medical treatment in Beijing Tongren Eye Center. Methods On basis of the axial length measured by OA-2000, the patients were divided into normal control group (22 mm≤AL<26 mm) and long axial group (AL≥26 mm). And the long axial group was further divided into 4 groups according to the axial length, namely, Group A (26 mm≤AL<28 mm) 187 cases (187 eyes), Group B (28 mm≤AL<30 mm) 140 cases (140 eyes), Group C (30 mm≤AL<32 mm) 130 cases, (130 eyes), Group D (AL≥32 mm) 93 cases (93 eyes). The ocular biological parameters were compared between eyes with normal axial and long axial group and each subgroup in the long axial group, and the correlation between axial length and ocular biological parameters, age and ocular biological parameters were analyzed. Main Outcome Measures AL, keratometry (Kf, Ks, Km), anterior chamber depth (ACD), lens thickness (LT), white to white (WTW). Results The Kf, Ks, Km, corneal astigmatism, ACD, LT, and WTW of patients in the long axial group was (43.07±1.61) D, (44.65±1.71) D, (43.91±1.62) D, (1.52±0.77) D, (3.28±0.47) mm, (4.55±0.41) mm, (11.52±0.45) mm, respectively. Which was (44.51±1.42) D, (45.47±1.52) D, (44.98±1.51) D, (0.92±0.66) D, (3.01±0.41) mm, (4.63±0.46) mm, (11.40±0.48) mm, respectively in the normal control group (all P<0.05). There were statistically significant differences in Kf, Ks, Km, corneal astigmatism, ACD, LT and WTW among the four sub groups in the long axial group with different axial lengths (all P<0.05). Through Pearson correlation analysis, in the long axial group, AL was positively correlated with LT and WTW (r=0.249, P<0.0001) and (r=0.182, P=0.002) respectively; it was negatively correlated with Kf, Ks, Km, ACD (r=-0.219, P<0.0001), (r=-0.183, P<0.0001), (r=-0.194, P<0.0001), (r=-0.328, P<0.0001) respectively. There was no correlation between age and Kf, Ks, Km, WTW (all P>0.05); it was positively correlated with LT (r=0.299, P<0.0001); it was negatively correlated with AL and ACD (r=-0.245, P<0.0001) and (r=-0.228, P<0.0001) respectively. Conclusion Compared with patients in the normal control group, patients in the long axial group had smaller Kf, Ks, Km, deeper ACD, thinner LT, and longer WTW. The AL of patients in the long axial group was positively correlated with LT and WTW, but negatively correlated with Kf, Ks, Km, and ACD. The age was positively correlated with LT but negatively correlated with AL and ACD. (Ophthalmol CHN, 2023, 32: 103-107)

Key words: biometry, axial length, keratometry, anterior chamber depth, lens thickness, white to white