Abstract:  Objective To observe the characteristics of ocular parameters in primary angle closure glaucoma (PACG) combined cataract patients with zonular abnormality found during cataract surgery. Design Retrospective comparative case series. Participants Patients with PACG who underwent cataract surgery from May, 2019 to December, 2020 at Beijing Tongren Hospital were reviewed, which include 45 PACG eyes with zonular abnormality found during cataract surgery(zonular abnormality group), 95 PACG eyes without zonular abnormality, and 41 eyes with secondary angle closure glaucoma induced by lens subluxation (SACG-LS). Methods Medical records of all patients were reviewed, including ocular parameters measured using IOL master and UBM.  Main Outcome Measures Anterior chamber depth (ACD), lens vault (LV), lens thickness (LT), and axial length (AL).  Results There was no statistically significant difference in AL [(22.07±0.78) mm vs (22.20±0.75) mm, P=0.650] and ACD [(1.61±0.31) mm vs (1.74±0.35) mm, P=0.074] between zonular abnormality group and without zonular abnormality group. LV was 1.41±0.35 mm in zonular abnormality group, 1.04±0.21 mm in without zonular abnormality group, and 1.73±0.45 mm in SACG-LS group. The LV differences between every two groups reached statistical significance (all P=0.000). The LV inter-eye difference reached statistical significance [(1.42±0.25) mm vs (1.24±0.27) mm, P=0.049] in zonular abnormality group. LT showed no statistical significance between zonular abnormality group and SACG-LS group [(5.14±0.26) mm vs (5.18±0.29) mm, P=0.808], and thicker than without zonular abnormality group. 80% patients of zonular abnormality group showed LV higher than 1.2 mm as well as LT thicker than 4.9 mm. Conclusion It is probability that the zonule may be abnormal in PACG patients with preoperative LV higher than 1.2 mm as well as LT thicker than 4.9 mm. (Ophthalmol CHN, 2021, 30: 264-269)

Key words:  primary angle closure glaucoma, zonule, lens vault, lens thickness