Abstract: Objective To analyze the predisposing factors and pathogenic microorganisms of 24 patients with endogenous endophthalmitis. Design Retrospective case series. Participants 24 patients (32 eyes) with endogenous endophthalmitis from Beijing Tongren Hospital from Jan. 2009 to Jan. 2013. Methods All patients were asked medical histories and routine ophthalmic examinations. Aqueous humor and vitreous specimens were taken by vitrectomy, and were smeared and cultured. Main Outcome Measures Predis -posing factors, the results of intraocular fluid cultivation. Results The main systemic predisposing factors included: diabetes mellitus in 4 cases (16.7%), surgeries in 3 cases (12.7%), liver abscess in 2 cases (8.4%), history of continuous high-strength working in 2 cases（8.4%）, urinary tract infection in 2 cases (8.4%), vaginitis in 2 cases (8.4%), long-term use of immunosuppressive agents in 1 case（4.2%）, oral infection in 1 case(4.2%), bacterial meningitis in 1 cases (4.2%) and respiratory infection in 1 case（4.2%）. Sixteen cases (66.7%) had a fever, and accepted systemic antibiotic treatment with a history of intravenous infusion. The positive rate of intraocular fluid cultivation was 54.8% (17 eyes). 45.2% (14 eyes) was fungal, especially candida albicans. 9.7% (3 eyes) was bacteria, and 2 eyes (6.5%) of the 3 eyes were pneumonia klebsiella bacillus. Conclusion The main predisposing factors of this group of patients were fever caused by different reasons, and the common causes included surgical operation, genito-urinary system infection and liver abscess. The main systemic disease was diabetes mellitus. The main pathogens were fungi, especially candida. And the main bacteria was pneumonia klebsiella bacillus.

Key words: endophthalmitis, predisposing factors, pathogenic microorganism