Table of Content

22 December 2016, Volume 40 Issue 6

Previous Issue    Next Issue

Current advance in the research of Trabectome surgery for open angle glaucoma

LIN Li, LIN Ding.

2016, 40(6):  361-364.  doi:10.3760/ cma. j. issn.1673\|5803.2016.06.001

Asbtract ( 386 )   PDF (861KB) ( 2220 )  

Related Articles | Metrics

The key to treat primary open\|angle glaucoma which prevent the high intraocular pressure and irreversible damage to the optic nerve,  is the surgery which

can control intraocular pressure. In recent years, minimally invasive glaucoma surgery (MIGS) has been applied to clinical therapy for glaucoma gradually. Trabectome surgery by increasing the physiologic trabecular meshwork aqueous humor drainage way, to achieve the goal of lower intraocular pressure, compared with the traditional  filtering methods.  Trabectome surgery which has small trauma, shorter operation time, intraoperative and less complications, fast recovery, good efficacy of lowing  IOP and easy post\|operative care etc,  has become more popular in recent years. It has been widely using in abroad in the clinical practice. This paper  on the basis of related research at homeland and abroad, reviewed the surgery principle, clinical efficacy, indications and complications of Trabectome surgery. (Int Rev Ophthalmol, 2016, 40: 361-364)

The research progress of children glaucoma with angle closure

ZHANG Ming1, XIE Yan-qian2, LIANG Yuan-bo2.

2016, 40(6):  365-368.  doi:10.3760/ cma. j. issn.1673\|5803.2016.06.002

Asbtract ( 288 )   PDF (794KB) ( 1910 )  

Related Articles | Metrics

The incidence of angle closure in glaucoma of children under 18 years of age is usually very low. According to the classification system presented by the World Federation of Glaucoma Association, this article analysed types of children glaucoma that angle closure are possible to happen and introduced the mechanism, treatment, especially with common types such as primary congenital glaucoma, ectopic lentis, glaucoma after cataract surgery, glaucoma related with retinopathy of prematurity were discussed. It is important to help clinical doctors to comprehend of the angle closure in children glaucoma and its guiding significance on treatment options. (Int Rev Ophthalmol, 2016, 40: 365-368)

Recent progress in research on oxidative stress markers in glaucoma

GAO Yan-|ting1, CAO Wen-jun1, SUN Xing-huai2

2016, 40(6):  369-374.  doi:10.3760/ cma. j. issn.1673.5803.2016.06.003

Asbtract ( 336 )  

Related Articles | Metrics

Oxidative stress is a possible risk factor of glaucoma, but its role involving in the mechanism of glaucoma hasn’t been well understood. Researches have

confirmed significant change of oxidative stress markers in samples from glaucoma patients including ocular specimens such as aqueous humor, trabecular meshwork and peripheral blood. Obvious change of oxidant or antioxidant level and pronounced presence of oxidative stress damage markers strongly prompted the imbalance between oxidant status and antioxidant status，which might play an important role in glaucomatous damage. Detection and analysis of oxidative stress markers profile in various samples，which combined with ophthalmic examination, would provide vital clues for clinical laboratory diagnosis and research of glaucoma. So in this review, current researches of oxidative stress markers in glaucoma will be discussed.(Int Rev Ophthalmol, 2016, 40: 369-374)

Effect of leukemia inhibitory factor in the pathogenesis of the nerve-related disorders in the eye

LV Jie-xuan, WU Ren-yi.

2016, 40(6):  375-379.  doi:10.3760/ cma. j. issn.1673.5803.2016.06.004

Asbtract ( 409 )  

Related Articles | Metrics

Leukemia inhibitory factor (LIF) is a multi\|functional cytokine which belongs to the interleukin\|6 family, and is widely expressed in animal and human tissues. In the nerve system, LIF is reported to be involved in many physiological and pathological processes. In the eyes, the protective role played by LIF in the optic nerve, the neuro\|retina and cornea has reported with increasing evidence. In glaucomatous eyes, by activating JAK/STAT3 pathway, LIF protects the optic nerve against injury and promotes the axon regeneration of the nerve. In eyes with age\|related macular degeneration and retinitis pigmentosa, LIF inhibits the death of the photoreceptors and maintains the function of them by the pathways related. In addition, LIF promotes the regeneration of the nerves in the cornea in case of injury. The neuroprotective role played by LIF in the eye suggests its potential clinical application in the treatment in the future. (Int Rev Ophthalmol, 2016, 40: 375-379)

Progress of pathogenesis research on exfoliation syndrome

LIU Xiao-di1, DING Lin2

2016, 40(6):  380-383.  doi:10.3760/cma.j.issn.1673.5803.2016.06.005

Asbtract ( 302 )  

Related Articles | Metrics

Exfoliation syndrome (XFS), one of the most common causes of secondary glaucoma, is an age-related, late-oneset, multifactorial systemic disease. The pathogenesis involves both genetic and environmental factors. However, the exact pathogenesis of XFS is still unclear. The purpose of this article was to review the progress of pathogenesis research in XFS, including the aspects of LOXL1 genetic polymorphism, gene hypermethylation, environmental factors, autophagy and so on, which may be involved in the formation and development of XFS. It can deepen the understanding of XFS,

expecting to contribute to the prevention and treatment of XFS.(Int Rev Ophthalmol, 2016, 40: 380-383)

Research progress on triterpenoids in eye diseases

ZHANG Min, KANG Li-hua, GUAN Huai-jin.

2016, 40(6):  384-390.  doi:10.3760/ cma. j. issn.1673.5803.2016.06.006

Asbtract ( 326 )  

Related Articles | Metrics

Triterpenoids represent a kind of secondary metabolites found in terrestrial and marine flora and fauna, which have a wide variety of biological activities and pharmacological properties, such as anti\|oxidation, anti\|inflammatory, anti\|cancer, anti-anaphylaxis, anti\|virus at all. The study of triterpenoids has become a research hotspot in various fields in recent years. Besides, oxidative stress, inflammation, angiogenesis and many other factors involved in the occurrence and development of different eye diseases. The role of triterpenoids in eye diseases, such as corneal diseases, uveitis, glaucoma, cataract, retinal diseases, optic neuropathy, retinoblastoma etc, have been widely studied.(Int Rev Ophthalmol, 2016, 40: 384-390)

Recent progress in investigation of potential therapeutic action of PPAR-γ in the diabetic retinopathy

JIANG Ling.

2016, 40(6):  391-394.  doi:10.3760/ cma. j. issn.1673.5803.2016.06.007

Asbtract ( 361 )  

Related Articles | Metrics

Diabetic retinopathy is an important cause of blindness. Inflammatory processes have an important role in the diabetic retinopathy. Peroxisome

proliferator-activated receptor-γ (PPAR-γ) not only increases insulin sensitivity, but also inhibits inflammatory processes and cell proliferation. Therefore,

activation of PPAR-γ may be effective for treating diabetic retinopathy. Those functions of PPAR-γ and ideas for medicine therapeutic to diabetic retinopathy are

summarized in this review. (Int Rev Ophthalmol, 2016, 40: 391-394)

Research progress of the effects of autophagy on diabetic retinopathy

DONG Li, KANG Yi-kun, WEI Wen-bin.

2016, 40(6):  395-399.  doi:10.3760/ cma. j. issn.1673.5803.2016.06.008

Asbtract ( 399 )  

Related Articles | Metrics

Diabetic retinopathy(DR) is the most common retinal vascular disease. Although a variety of pathogenesis for DR was detected, it has not yet been fully clarified. Recent studies have found autophagy may play an important role in the pathogenesis of DR by changing intracellular homeostasis, oxidative stress, endoplasmic reticulum stress, cell apoptosis and excessive autophagy. And improving autophagy or inhibiting excessive autophagy may have a potential value in the treatment of DR.(Int Rev Ophthalmol, 2016, 40: 395-399)

Progress in the treatment of wet age-related macular degeneration with Ranibizumab

KONG Li1, WANG Wen-juan2, HE Rong-hua3, ZHOU Guo-hong2

2016, 40(6):  400-404.  doi:10.3760/ cma. j. issn.1673.5803.2016.06.009

Asbtract ( 462 )  

Related Articles | Metrics

Wet age\|related macular degeneration (AMD) is one of the main causes of vision loss in elderly people, and its etiology is not clear. In terms of pathogenesis, it has been confirmed that vascular endothelial growth factor and wet AMD have a clear correlation. Therefore, there are many kinds of anti\|vascular endothelial growth factor drugs used in the disease. Intravitreal Ranibizumab can inhibit vascular endothelial growth factor and block the growth and leakage of new blood vessels to play a role.The Ranibizumab has been shown to be a definite therapeutic effect in the treatment of wet AMD. The progress of Ranibizumab in the treatment of wet AMD is reviewed in this article, including the treatment efficacy, the factors of affecting the efficacy, the combined therapy, and the adverse reaction and so on.(Int Rev Ophthalmol, 2016, 40: 400-404)

Research status of transsynaptic retrograde degenerating optic neuropathy

MAO Jun-feng1, WEI Shi-hui2

2016, 40(6):  405-409.  doi:10.3760/ cma. j. issn.1673.5803.2016.06.010

Asbtract ( 395 )  

Related Articles | Metrics

Transsynaptic retrograde degeneration of retinal ganglion cells was induced by a lesion in the lateral geniculate nucleus, and/or the visual cortex of occipital lobe. This optic neuropathy is referred to as transsynaptic retrograde degenerating optic neuropathy, and its pathological basis is the apoptosis of P beta retinal ganglion cells.The degenerating extent depends on the age at which visual cortex was damaged, the survival time,the size of the cortical lesion,the binocular interactions and the species.(Int Rev Ophthalmol, 2016, 40: 405-408)

Explanation for location of preferred retinal locus in low-vision patients

CHEN Xiao-xiao, LI Meng-wei, SUN Xing-huai.

2016, 40(6):  409-413.  doi:10.3760/ cma.j.issn.1673.5803.2016.06.011

Asbtract ( 362 )  

Related Articles | Metrics

Macular diseases always result in central scotoma. In such cases, formation of substitute peripheral retinal plays an important role in eccentric viewing to avoid visual difficulties. Researches have been accomplished to prove that adopting a peripheral retinal location for fixation (preferred retinal locus, PRL) helps improving visual activities such as reading and searching. Thus it’s necessary to conduct perceptual training in patients using non\|foveal location on the retina. One of the key, yet unresolved questions related to central scotoma is what determines the location of the PRL. The purpose of this review is to summarize key findings on explanation for location of PRL, including function\|driven explanation of PRL, performance\|driven explanation of PRL and retinotopy\|driven explanation of PRL. (Int Rev Ophthalmol, 2016, 40: 409-413)

The treatment progress of the infantile nystagmus syndrome

CHEN Jun-jue, KANG Xiao-li.

2016, 40(6):  414-419.  doi:10.3760/ cma. j. issn.1673.5803.2016.06.012

Asbtract ( 350 )  

Related Articles | Metrics

Infantile nystagmus syndrome (INS) is pathologic nystagmus that presents at birth or early infancy. It is clinically characterized by involuntary and conjugated oscillation of the eye.This disease cannot be cured completely. However, the method of treatment has got progress, such as the optometry treatments of optical glasses, contact lenses, prisms, eyesight\|aiding devices and laser therapy, drug treatments of carbonic anhydrase inhibitors, botulinum toxin extraocular muscle injection, and biofeedback therapy of auditory feedback, as well as new surgical methods.(Int Rev Ophthalmol, 2016, 40: 414-419)

Review of clinical imaging technique on amblyopia

ZHANG Ao, YAN Xing-ke, LIU An-guo.

2016, 40(6):  420-425.  doi:10.3760/ cma. j. issn.1673.5803.2016.06.013

Asbtract ( 280 )  

Related Articles | Metrics

Imaging technique is significant in studying amblyopia, which mainly includes MRI (magnetic resonance imaging), MEG (magnetoencephalography), SPECT(single photon emission computed tomography), PET (positron emission tomography), fMRI (functional magnetic resonance imaging), DTI (diffusion tensor imaging), SLP (scanning laser polarimetry), OCT (optical coherence tomography), and so on. In recent years, studys on amblyopia based on imaging technique methods have achieved plenty of new findings.To review the progress of clinical imaging technique on amblyopia, study results from pertinent literatures are summed up and discussed in this paper, which does not only summarize the definition, the mechanisms and the meaning of these indexes in the relevant research progress in recent years, but also makes a comment on the advantages and the disadvantages of MRI, MEG, SPECT, PET, fMRI, DTI, SLP and OCT. (Int Rev Ophthalmol, 2016, 40: 420-425)

Research progress meibomian gland dysfunction

MENG Zhu, ZHAO Shao-zhen.

2016, 40(6):  426-431.  doi:10.3760/ cma. j. issn.1673.5803.2016.06.014

Asbtract ( 351 )  

Related Articles | Metrics

Meibomian gland dysfunction (MGD) is a common ocular surface disease , characterized by terminal duct obstruction and (or) quality or quantity changes in the glandular secretion．The corresponding change of lipid composition results in the decline of tear flim stability and the increase of tear evaporation, which leads to dry eye. At this point,the causes of MGD remain unknown.Symptomatic therapy is commonly used clinical thrapeutic measures.In this article we mainly summarized the change of lipid and the development of diagnosis and treatment of MGD at home and abroad．(Int Rev Ophthalmol, 2016, 40: 426-431)