血浆置换治疗急性期视神经炎

doi:10.13281/j.cnki.issn.1004-4469.2017.01.004

眼科

血浆置换治疗急性期视神经炎

庄远徐全刚魏世辉

100853 北京，解放军总医院输血科（庄远）；解放军总医院眼科（徐全刚、魏世辉）

收稿日期:2016-10-26 出版日期:2017-01-25 发布日期:2017-01-20
通讯作者: 徐全刚，Email：xuquangang@126.com

Therapeutic plasma exchange for acute optic neuritis

ZHUANG Yuan1, XU Quan-gang2, WEI Shi-hui2.

1. Department of Transfusion, General Hospital of PLA, Beijing 100853, China; 2. Department of Ophthalmology, General Hospital of PLA, Beijing 100853, China

Received:2016-10-26 Online:2017-01-25 Published:2017-01-20
Contact: XU Quan-gang, Email: xuquangang@126.com

摘要/Abstract

摘要：

治疗性血浆置换（therapeutic plasma exchange，TPE）能有效清除血清中的抗体及促炎性细胞因子等致病物质，并对患者免疫功能具有调节作用。急性视神经炎甲泼尼龙静滴（intravenous methylprednisolone，IVMP）3~5天视力恢复不明显或不宜继续用糖皮质激素治疗者可考虑应用TPE，但应注意过敏反应和电解质紊乱等不良事件的防范。TPE对急性视神经炎的确切疗效以及最佳治疗方案等问题，尚需进一步循证研究。（眼科， 2017， 26： 6-9）

关键词: 视神经炎, 治疗性血浆置换

Abstract:

Therapeutic plasma exchange (TPE) can remove the pathogenic components effectively such as autoimmune antibodies and proinflammatory cytokines in serum. It may also modify the immune function of patients. If patients with acute optic neuritis (ON) do not respond to intravenous methylprednisolone (IVMP) therapy or they are intolerant to IVMP, TPE may be beneficial in the acute setting. However, adverse events such as allergy and electrolyte disturbances should be alerted. The exact effect of TPE for acute ON and its optimal treatment strategy need to be further investigated. (Ophthalmol CHN, 2017, 26: 6-9)

Key words: optic neuritis, therapeutic plasma exchange

庄远徐全刚魏世辉. 血浆置换治疗急性期视神经炎[J]. 眼科, doi: 10.13281/j.cnki.issn.1004-4469.2017.01.004.

ZHUANG Yuan1, XU Quan-gang2, WEI Shi-hui2. . Therapeutic plasma exchange for acute optic neuritis [J]. Ophthalmology in China, doi: 10.13281/j.cnki.issn.1004-4469.2017.01.004.

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血浆置换治疗急性期视神经炎

Therapeutic plasma exchange for acute optic neuritis

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