眼科 ›› 2012, Vol. 21 ›› Issue (6): 376-380.

• 论著 • 上一篇    下一篇

短期配戴角膜塑形镜对中央和周边角膜厚度的影响

 翟洲,  杨晓,  王化荣,  方冰兰,  戴祖优,  魏玲   

  1. 510060  广州,中山大学中山眼科中心 眼科学国家重点实验室
  • 收稿日期:2012-10-07 出版日期:2012-11-25 发布日期:2012-11-26
  • 通讯作者: 杨晓, Email: yangxiao3366@gmail.com
  • 基金资助:

    广东省科技计划资助课题(2009B030801169)

The short-term effects of orthokeratologic lens on central and peripheral corneal thickness

 DI  Zhou,   Yang-Xiao,   Wang-Hua-Rong,   Fang-Bing-Lan,   Dai-Zu-You,   Wei-Ling   

  1. Zhongshan Ophthalmic Center of Zhongshan University, Ophthalmology State Key Laboratory, Guangzhou 510060, China
  • Received:2012-10-07 Online:2012-11-25 Published:2012-11-26
  • Contact: YANG Xiao, Email: yangxiao3366@gmail.com

摘要: 【摘要】 目的 观察过夜配戴角膜塑形镜3个月后中央和周边角膜厚度的变化。设计 前瞻性病例系 列。研究对象 103例(197眼)近视患者,平均年龄(19.0±7.5)岁,平均等效球镜度(-3.25± 0.91)D。方法 过夜戴角膜塑形镜,采用眼前段分析仪(Pentacam)测量角膜厚度,观察配戴前后 1天、1个月和3个月角膜中央和距中央半径1、2、3、4 mm处角膜厚度的变化。同时观察屈光度和角 膜地形图中央角膜屈光力的变化。主要指标 角膜厚度、等效球镜度、中央角膜屈光力。结果 戴镜 3个月后等效球镜度减少(-3.01±0.09)D,与戴镜前比较差异有统计学意义(P=0.00)。戴镜3个 月后角膜中央屈光力减少(2.40±0.15)D,与戴镜前比较差异有统计学意义(P=0.00)。戴镜1天 不同位点角膜厚度均增厚,中央区、半径1 mm、2 mm、3 mm、4 mm处角膜分别增厚(5.90±3.69) μm、(7.54±3.73)μm、(10.52±3.91)μm、(11.76±4.23)μm、(9.33±4.93)μm。戴 镜1个月,中央、半径1 mm处厚度分别减少(-4.18± 3.68)μm、(-0.50±3.73)μm;半径2、 3、 4 mm处角膜厚度分别增加(6.39±3.91)μm、 (9.57±4.22)μm、 (2.00±5.05)μm; 戴镜3个月,中央、半径1 mm处角膜厚度分别减少(-6.61±3.67)μm、 (-3.67±3.72)μm,半 径2、 3、4 mm处角膜厚度分别增加(3.05±3.90)μm、 (6.42±4.21)μm、 (5.63±4.94) μm。除半径4 mm位点以外,其他各角膜位点在不同配戴时间的角膜厚度变化均有统计学意义(P均 <0.05)。中央角膜厚度随时间变化的速度快于周边角膜厚度(P=0.00)。结论 短期配戴角膜塑形 镜后角膜不同位点厚度的变化与角膜形状改变一致,中央角膜变薄,从旁中央半径2 mm开始角膜增 厚。(眼科, 2012, 21: 376-380)

关键词: 近视眼, 角膜塑形镜, 角膜厚度

Abstract: 【Abstract】 Objective To observe the short-term changes of the central and peripheral corneal thickness after wearing orthokeratology (OK) contact lenses overnight. Design Prospective case series. Participants 103 patients (197 eyes) with myopia, average ages 19.0±7.5 years, average spherical equivalent refraction-3.25±0.91 diopters (D). Methods All the patients wore orthokeratology lens overnight. The corneal thickness was measured with a rotating Scheimpflug camera (Pentacam) on different corneal areas, including central, peripheral corneal ring on radius 1 mm, 2 mm, 3 mm and 4 mm. The changes of spherical equivalent refraction and central corneal radius of corneal topography were measured also. All the examinations were done on baseline and 1 day, 1 month, 3 months after wearing OK. Main Outcome Measures Corneal thickness (CT), spherical equivalent refraction (SER), central corneal radius (CCR). Results Compared with baseline, SER reduced -3.01±0.09 D in 3 months and CCR reduced 2.40±0.15 D (both P<0.05). After 1 night wearing, compared with pre-wearing CT increased 5.90± 3.69 μm, 7.54±3.73 μm, 10.52±3.91 μm, 11.76±4.23 μm, 9.33±4.93 μm from the center, to radius 1 mm , 2 mm, 3 mm and 4 mm respectively (all P<0.05).  After 1 month, CT reduced -4.18±3.68 μm and -0.50±3.73 μm in the center and radius 1 mm respectively, but increased 6.39±3.91 μm,9.57±4.22 μm,2.00±5.05 μm in radius 2 mm, 3 mm, 4 mm, respectively. After 3 months, CT reduced -6.61±3.67 μm and -3.67± 3.72 μm in the center and radius 1 mm respectively. But CT increased 3.05±3.90 μm, 6.42±4.21 μm, 5.63±4.94 μm in  radius 2 mm, 3 mm, 4 mm, respectively (all P<0.05). The central corneal thickness changed faster than peripheral corneal thickness in different time (P=0.00). Conclusion The changes of corneal thickness after wearing orthokeratology lenses are consistent with the changes of the shape of cornea. The central cornea becomes thin and the cornea from radius 2 mm to peripheral becomes thick. (Ophthalmol CHN, 2012, 21: 376-380)

Key words: myopia, orthokeratology, corneal thickness