关键词: 近视眼/外科学, 准分子激光原位角膜磨镶术, 泪液分泌, 泪膜稳定

Abstract: 【Abstract】 Objective To analyze the change of tear film after femtosecond laser assisted LASIK surgery. Design Retrospective case series. Participants The 120 myopic patients (235 eyes) who underwent femtosecond laser surgery from March to June 2011 in Ningbo Ophthalmic Hospital Myopia Laser Center.  Methods The Intralse femtosecond laser was used to produce the corneal flap with an above root. The routine excimer LASIK was performed. The Levofloxacin eye drops were used 4 times/day,  beginning from post surgery 1st day and stopping at one week post surgery.  The 0.1% fluorometholone eye drops were used post surgery, 4 times a day at the first week, 3 times a day at the second week, twice a day at the third week and once a day at the fourth week and then stopped.  The tear film break-up-time (BUT) and Schirmer I test were performed in all patients before surgery,  and at post surgery 10th day, 1st, 3rd, 6th month,  to observe the tear film changes after surgery. Main Outcome Measures BUT, Schirmer I test results. Results At pre-operation, the BUT was（15.00±2.56）s. At post surgery 10th day, the 1st month , the 3rd month and the 6th month, the value of BUT was 8.51± 3.22 s，11.4±2.71 s，14.29±3.46 s and 14.84±3.01 s, respectively. The corresponding value of Schirmer I test was 16.23±3.48 mm, 9.86±3.13 mm， 13.46±2.72 mm， 15.18± 3.02 mm and 16.11±2.84 mm, respectively. At the 10th day, the 1st month and the 3rd month after surgery, these two results were  statistically significantly different compared to preoperations’(all P<0.05); but  at the 6th month, the difference was not significant(P=0.22). Conclusion Femtosecond laser assisted LASIK, at early period postoperatively, lead to an tear film unstability and tear secretion reduction, which created the feeling of dry eye in patients. But the tear secretion and tear film stability  gradually restored at 3rd month after surgery. After 6th month, the tear recovered completely and became stabilized again. （Ophthalmol CHN, 2012, 21: 387-389）

Key words: myopia/surgery, laser in situ keratomileursis, tear secretion, tearfilm stability