准分子激光原位角膜磨镶术术后早期应用卡替洛尔滴眼液对屈光状态的影响

眼科 ›› 2013, Vol. 22 ›› Issue (1): 49-52.

准分子激光原位角膜磨镶术术后早期应用卡替洛尔滴眼液对屈光状态的影响

李蓉许艳张丰菊王萌萌

100730 首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科学与视觉科学重点实验室（李蓉、许艳、张丰菊、王萌萌）；新疆医科大学附属中医医院眼科（李蓉，北京同仁医院眼科进修医师）

收稿日期:2012-03-15 出版日期:2013-01-25 发布日期:2013-01-30
通讯作者: 张丰菊，Email：wxw93@hotmail.com
基金资助:
国家“十二五”科技支撑计划子课题（2011BAI1208）

Effects of carteolol application on the refractive outcomes after laser in situ keratomileusis

LI Rong, XU Yan, ZHANG Feng-ju, WANG Meng-meng.

Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

Received:2012-03-15 Online:2013-01-25 Published:2013-01-30
Contact: ZHANG Feng-ju, Email: wxw93@hotmail.com

摘要/Abstract

摘要： 目的评估准分子激光原位角膜磨镶术（LASIK）术后早期应用盐酸卡替洛尔滴眼液对屈光状态及眼压的影响。设计前瞻性比较性病例系列。研究对象 2009年11月-2011年9月北京同仁医院行LASIK手术的近视患者32例（32眼）。方法试验组15眼LASIK术后第1周开始使用2%盐酸卡替洛尔滴眼液每日2次，低中度近视患者持续1个月，高度近视患者持续1.5个月。对照组17眼术后不使用2%盐酸卡替洛尔滴眼液。术前、术后1、3、6个月进行显然验光、Oculyzer眼前节测量系统、眼压等检查。主要指标等效球镜度、角膜后表面高度、眼压。结果试验组术后1、3、6个月时等效球镜度分别为（-0.150±0.742）、（-0.170±0.595）和（-0.525±0.618）D；对照组分别为（-0.258±0.581）、（-0.290±0.657）和（-0.459±0.591）D（P均＞0.05）。试验组术后1、3、6个月时角膜后表面高度分别为（7.47±2.326）、（6.60±3.158）和（5.86±2.610）μm；对照组分别为（6.59±3.355）、（7.35±3.622）和（7.33±2.992）μm（P均＞0.05）。试验组术后1、3、6个月眼压分别为（7.80±0.941）、（8.07±1.534）、（8.70±1.337） mm Hg；对照组分别为（9.35±2.827）、（9.59±2.717）、（8.73±1.580）mm Hg。术后1个月时试验组和对照组眼压有统计学差异（P=0.045），余时间点均无统计学差异。结论 LASIK术后早期应用盐酸卡替洛尔滴眼液通过降低眼压可能对屈光状态具有稳定作用。（眼科，2013，22：49-52）

关键词: 准分子激光原位角膜磨镶术, 眼压, 等效球镜度, 卡替洛尔滴眼液

Abstract: Objective To assess the effects on refraction and intraocular pressure by early carteolol eyedrops application on eyes after laser in situ keratomileusis (LASIK). Design Prospective comparative case series. Participants 32 eyes of 32 patients with myopia undergone LASIK at Beijing Tongren Hospital were included. Methods 2% carteolol hydrochloride eye drops (15 eyes) were administered topically twice a day from the second week after LASIK to the end of the first month for patients with low to moderate myopia and through the end of the 1.5 months for patients with high myopia. 2% carteolol hydrochloride in control group (17 eyes) wasn't administered. The changes of spherical equivalent correction (SE) , the posterior corneal surface different value (Diff) and intraocular pressure (IOP) were observed preoperatively and 1 month, 3 months and 6 months after LASIK, respectively. Main Outcome Measures SE, the posterior corneal surface different value and IOP. Results The average SE of treatment group was (-0.150±0.742) D, (-0.170±0.595) D and (-0.525±0.618) D respectively at 1 month, 3 months and 6 months postoperatively, while it was (-0.258±0.581) D, (-0.290±0.657) D, and (-0.459±0.591) D respectively in the control group (all P>0.05). The posterior corneal surface Diff of treatment group was (7.47±2.326) μm, (6.60±3.158) μm, and (5.86±2.610) μm respectively at 1 month,3 months and 6 months postoperatively, while it was (6.59±3.355) μm, (7.35±3.622) μm, and (7.33±2.992) μm respectively in the control group (all P>0.05). The IOP of treatment group was (7.80±0.941)mm Hg,(8.07±1.534) mm Hg and (8.70±1.337) mm Hg respectively at 1 month, 3 months and 6 months postoperatively, while it was (9.35±2.827) mm Hg, (9.59±2.717) mm Hg and (8.73±1.580) mm Hg, respectively in the control group. The difference between the two groups was only significant (P=0.045) at 1 month. Conclusions Carteolol is effective to reduce IOP in early stage after LASIK and helpful to enhance the stability of the corneal biomechanical and the refraction. (Ophthalmol CHN, 2013, 22: 49-52)

Key words: laser in situ keratomileusis, introcular pressure, spherical equivalent, carteolol eyedrops

李蓉许艳张丰菊王萌萌. 准分子激光原位角膜磨镶术术后早期应用卡替洛尔滴眼液对屈光状态的影响[J]. 眼科, 2013, 22(1): 49-52.

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