眼科

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原发性闭角型青光眼首选治疗指征探讨

张明  范肃洁  梁远波   韩伟  王宁利   

  1. 210009 南京,东南大学附属中大医院眼科(张明);056001 河北省邯郸市第三人民医院 邯郸眼科医院(范肃洁、韩伟);325027 温州医科大学附属眼视光医院(梁远波); 100730 首都医科大学附属北京同仁医院 北京同仁眼科中心(王宁利)
  • 收稿日期:2016-12-22 出版日期:2017-01-25 发布日期:2017-01-20
  • 通讯作者: 梁远波,Email:yuanboliang@126.com
  • 基金资助:

    浙江省卫生创新人才培养计划(2016025)

The indications of initial treatment for angle-closure glaucoma

ZHANG Ming1, FAN Su-jie2, LIANG Yuan-bo3, HAN Wei2, WANG Ning-li4.   

  1. 1. Department of Ophthalmology, Affiliated Zhong Da Hospital of Southeast University, Nanjing 210009, China; 2. Handan Eye Hospital, Handan 056001, China; 3. Eye and Optometry Hospital, Wenzhou Medical University, Wenzhou 325027, China; 4. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
  • Received:2016-12-22 Online:2017-01-25 Published:2017-01-20
  • Contact: LIANG Yuan-bo, Email: yuanboliang@126.com

摘要:

目的 探讨原发性闭角性青光眼(primary angle-closure glaucoma,PACG)我国传统治疗方案与美国眼科学会推荐首选治疗方案两种治疗模式对治疗结局的影响。设计 回顾性病例系列。 研究对象 2005年10月至2007年3月邯郸市眼科医院连续诊治的急性闭角型青光眼(acute angle closure glaucoma,AACG)148眼和慢性闭角型青光眼(chronic angle closure glaucoma,CACG)245眼。方法 利用以激光周边虹膜切开术(laser peripheral iridotomy,LPI)作为首选治疗后1~18个月的随访数据,分析激光治疗后眼压控制的情况。分析比较我国传统治疗方案即以房角周边前粘连(peripheral anterior synechiae,PAS)>6个钟点作为小梁切除术的指征可能存在的过度治疗(即激光治疗后眼压可以控制)和治疗不足(即激光治疗后眼压不能控制,需进一步用药或手术治疗)的比例。主要指标 过度治疗和治疗不足的比例。 结果 按照我国传统治疗方案中PACG的处理原则,45只AACG眼将行小梁切除术,而其中46.7%(21/45)的患眼行激光治疗眼压即可控制;CACG中将有89只眼需行小梁切除术,其中约49.4%(44/89)的患眼可仅行LPI。采用激光治疗模式,AACG中激光治疗后眼压不能控制的病例将从传统治疗模式的10.8%(16/148)上升为29.7% (44/148),CACG激光治疗后眼压不能控制的将从18.4%(45/245)上升为42.4% (104/245)。结论 按照我国传统滤过手术治疗原则治疗PACG存在严重的过度治疗。如果完全以LPI作为首选治疗,将导致治疗不足或失败的比例明显增加,约为我国传统滤过手术治疗模式的2~3倍。因此,结合房角粘连程度和视神经损害的有无确定PACG的滤过手术指征,可避免或减少过度治疗与治疗不足。(眼科,2017,26: 15-20)

关键词: 原发性闭角型青光眼, 激光周边虹膜切除术, 小梁切除术

Abstract:

Objective To compare the Chinese conventional practice patterns of primary angle-closure glaucoma (PACG) with American Academy of Ophthalmology recommended practice patterns in a setting of tertiary eye hospital in China.  Design Retrospective case series. Participants 148 eyes with acute angle closure glaucoma (AACG) and 245 eyes with chronic angle closure glaucoma (CACG) between October 2005 and March 2007 at Handan Eye Hospital. Methods All eyes were undergone laser peripheral iridotomy (LPI), with a follow up time of 1-18 months. Based the database, we assumed to treat the patients with Chinese conventional practice patterns, to see the proportions of overtreatment and the potential undertreatment. Main Outcome Measures The ratio of overtreatment and undertreatment. Results In accordance with conventional practice patterns for PACG in China, 45 AACG eyes and 89 CACG eyes will take trabeculectomy, among which 46.7% (21/45) of AACG eyes and 49.4% (44/89) of CACG eyes can be well controlled by LPI, respectively. With laser preferred strategy, the rate of inadequate treatment will be increased from 10.8%(16/148)to 29.7% (44/148) in AACG eyes and from 18.4% (45/245) to 42.4% (104/245) in CACG eyes. Conclusion Filtery surgery in PACG is seriously overdone in China with conventional practice patterns. The rate of inadequate treatment will be increased remarkablely with laser preferred practice pattern, about 2-3 times compared with the traditional mode of filtration surgery. Therefore, taking both the degree of PAS and optic nerve damage into the consideration of choosing filtration surgery or not for PACG patients, may be utmost to avoid excessive treatment and reduce the inadequate treatment. (Ophthalmol CHN, 2017, 26: 15-20)

Key words: primary angle closure glaucoma, laser iridotomy, trabeculectomy