Abstract: Objective Clinical data of 17 patients with Wegener’s granulomatosis of the orbit were analyzed, in order to improve the management of this disease. Design Retrospective case series. Participants 17 patients who pathalogically diagnosed as the ophthalmic involvement due to WG from January 2000 to June 2014 at Armed Police General Hospital. Methods Medical records of all patients were reviewed. The ocular and systemic clinical manifestations, auxiliary examinations and the prognosis were record and analyzed. Main Outcome Measures Ocular and systemic clinical manifestations, auxiliary examinations, and the prognosis. Results Of 17 patients, 7 were female. The ages of patients at disease onset varied from 17 to 65, average 38.4±13.2 years. WG may affect any part of the eye, including the eyeball, lacrimal gland, extraocular muscles, optic nerve and orbital soft tissues, etc. c-ANCA positive reaction was seen in 7 patients (7/8 cases). WG can be controlled with glucocorticoid and other immunosuppressive therapies or combined use of local radiotherapy (4/11 cases). 2 patients relapsed. 2 patients died of renal failure and 1 patient died of respiratory failure during the period of follow-up. Conclusion WG is a fatal disease involving any organ system, can affect any part of the eye. Positive c-ANCA and pathological examination were helpful to the diagnosis. Treatment with glucocorticoid and other immunosuppressive therapies or combined use of local radiotherapy could achieve good outcome.

Key words: text-indent: 0px, font: medium Simsun, white-space: normal, letter-spacing: normal, color: rgb(0,0,0), word-spacing: 0px, -webkit-text-stroke-width: 0px" id="x-393-anchor" name="x-393-anchor">

Wegener's granulomatosis, ocular, anti-neutrophil cytoplasmic antibody, clinical manifestation