Abstract: Objective To observe the response of different activity of age-related macular degeneration(AMD) to anti-vascular endothelial growth factor (VEGF) treatment observed by optical coherence tomography angiography(OCTA), and to analyze the correlation between the difference of response and the imaging features of choroidal neovascularization (CNV). Design Retrospective case series. Participants 54 patients (54 eyes) with wet AMD confirmed by fluorescein fundus angiography and/or indocybanine green angiography in Suzhou Municipal Hospital(North District). Methods According to the morphology of macular CNV based on OCTA, AMD patients were divided into active group and inactive group. The average number of anti VEGF was (4.06±0.89) in the active group and (3.83±0.79) in the inactive group. The differences of best corrected visual acuity (BCVA)(LogMAR) and central macular thickness (CMT) before and after anti-VEGF treatment were observed. The average follow-up was (4.17±1.02) months. Main Outcome Measures BCVA, CMT. Result In the active group, BCVA ( LogMAR)was (0.36±0.12) after anti-VEGF treatment, which was significantly higher than that before treatment (0.59±0.10) (t=5.962, P=0.000). In the inactive group, the BCVA of patients after anti-VEGF treatment was (0.62±0.11), which was not significantly higher than that before treatment (0.70±0.13) (t=1.445, P=0.182). In the active group, the CMT after anti-VEGF treatment was (286.17±97.47) μm, which was significantly lower than that before treatment (350.09±131.09) μm (t=3.792, P=0.001). In the inactive group, the CMT after anti-VEGF treatment was (222.40±34.93) μm, which was significantly lower than that before treatment (302.93±132.67) μm (t=2.756, P=0.015). Conclusion The morphological features of different active CNV observed by OCTA can effectively assess the response to anti-VEGF treatment in wet AMD patients. Wet AMD patients with active CNV have a good response to anti-VEGF treatment.  (Ophthalmol CHN, 2021, 30: 349-353)

Key words: age-related macular degeneration, vascular endothelial growth factor, optical coherence tomography angiography