Abstract: Objective To investigate the efficacy and safety of deproteinized calf blood deproteinized extract eye drops on ocular surface conditions in adolescent myopic patients wearing orthokeratology lenses. Design Case-control study. Participants A total of 116 adolescent myopic patients (232 eyes) wearing orthokeratology lenses admitted to Shaoxing Central Hospital from January 2018 to January 2021 were selected and randomly divided into the control group (58 cases, 116 eyes) and the observation group (58 cases, 116 eyes). Methods The control group wore orthokeratology lenses in routine and the observation group used calf blood deproteinized extract eye drops during the day on the basis (1 drop/eye, 4 times/day). The uncorrected visual acuity (UCVA), diopter and axial length, corneal curvature, corneal surface regularity index (SRI), tear break-up time (BUT), tear film lipid layer thickness (LLT), conjunctivitis, ocular hypertension, photophobia discomfort and the incidence of corneal epithelial staining complications were compared between the two groups after 1 month of treatment. Main Outcome Measures UCVA, diopter and axial length, corneal curvature, SRI, BUT, LLT, and complications. Results Compared with before treatment, the UCVA and diopter of the two groups were apparently improved after treatment, the corneal curvature was apparently reduced, and the SRI level was apparently increased (all P<0.05). There was no significant difference in UCVA, diopter, axial length, corneal curvature and SRI level between the two groups after the treatment (all P>0.05). Compared with before treatment, the levels of BUT and LLT in the two groups were apparently decreased after treatment (P<0.05), and the observation group [(7.34±2.10) s, (60.52±10.84) nm] was apparently higher than those in the control group [(6.26±2.03) s, (55.20±11.73) nm] (all P<0.001); after treatment, there was no significant difference in the incidences of conjunctivitis, high intraocular pressure and photophobia between the two groups (all P>0.05). The incidence of corneal epithelial staining (8.62%) was apparently lower than that of the control group (24.14%) (P=0.024). Conclusion The ocular surface condition can be improved after auxiliary instillation of calf blood deproteinized extract eye drops in adolescent myopic patients who wear orthokeratology lenses without affecting the correction effect of orthokeratology lenses. (Ophthalmol CHN, 2022, 31: 231-234)

Key words: calf blood deproteinized eye drops, orthokeratology, juvenile myopia, tear film, corneal epithelium