Abstract: Objective To summarize the clinical characteristics of Behcet's syndrome, further understand the clinical characteristics and pathogenesis in Xinjiang Uygur Autonomous Region. Design Retrospective case series. Participants 508 BS patients in the People's Hospital of Xinjiang Uygur Autonomous Region from January 2005 to 2020. Methods The demographics and clinical data of BS patients were reviewed. Main Outcome Measures Age, gender, initial symptoms, eye lesions, medication drugs and complications. Results Among the 538 BS patients, the ratio of male to female was 1:1.96. The average age was 37.37±12.83 years, the average course of disease was 4.72±6.40 years, and the average hospital stay was 13.44±8.70 days. The first visit department was mostly rheumatology(57.0%), and oral ulcer was the most common initial symptom (69.7%) and clinical manifestation (94.1%). For medication, immunosuppressant accounted for 76.4% and thalidomide was used most frequently. Oral hormone accounted for 37.7% and the use rate of biological agents was 1.5%. About 1/5 BS patients underwent eye examination during hospitalization. 1/3 patients had uveitis, and binocular uveitis was the most common type. Uveitis had more serious visual impairment and a higher hormone use rate. Conclusion Most BS in Xinjiang Uygur Autonomous Region is young and middle-aged people. The rheumatology department and is the most common first visit departments. The oral ulcer is the most common symptom. Hormones and immunosuppressants are still the most commonly used for the treatment of BS. The use rate of biological agents is low. (Ophthalmol CHN, 2022, 31: 375-378)

Key words: Behcet's syndrome, uveitis