Abstract: Objective To study the influence of intraocular pressure(IOP)-lowering treatment on visual evoked potential (VEP) in eyes with anterior ischemic optic neuropathy(AION). Design Retrospective comparative case series. Participants From 2008 to 2011, a total of 68 cases of AION in the Second People's Hospital of Gansu were enrolled. The participants were randomly divided into control group (non-IOP-intervention) with a total of 30 cases (30 eyes) and lowering IOP group (IOP intervention) with a total of 38 cases (38 eyes). Methods The patients in IOP intervention group underwent an IOP lowering treatments to reduce IOP≥8 mm Hg or lower the IOP≥30%. All the eyes underwent  pattern visual evoked potential (PVEP) test. The PVEP characteristies were analyzed both groups before and after treatment. Main Outcome Measures  P100 latency, P100 amplitude of the PVEP. Results P100 latency in the intervention group (93.82±1.97 ms) was significantly shorter than non-IOP intervention group  (112.38±1.45 ms) (t=46.36, P<0.001); P100 amplitude in the intervention group(3.64±0.23 μv) was significantly higher than non-IOP intervention group (3.14±0.23 μv) (t= 8.76, P<0.001). Conclusion Intraocular pressure-lowering treatment in AION eyes was benifitrial to PVEP. （Ophthalmol CHN, 2012, 21: 316-318）

Key words: anterior ischemic optic neuropathy, intraocular pressure, pattern reversal visual evoked potential