关键词: 糖尿病视网膜病变, 炎症, 细胞因子, 血管内皮生长因子

Abstract: Vascular endothelial growth factor, interleukin-1, interleukin-8, tumor necrosis factor and other inflammatory cytokines play an important role in the occurrence and development of diabetes retinopathy (DR), which can induce the activation and migration of leukocytes, leading to capillary obstruction, retinal hypoxia and endothelial cell damage. Then the blood retinal barrier ruptured, and edema, hemorrhage, exudation and microaneurysm formed in the retina. Under the stimulation of persistent inflammatory reaction and cytokines, local pathological neovascularization occurs in the retina, which aggravates the progression of DR. Inflammatory factors in vitreous and aqueous humor are related to the progression of DR. In immune pathology, the inflammatory process induces a series of complex molecular and cellular signaling, which changes the physiological response of the affected eye tissues, thereby generating an inflammatory phenotype. These inflammatory biomarkers can evaluate the inflammatory process, and reliable and easily available inflammatory biomarkers will provide valuable information for the development of new DR biomarkers and their treatments. (Int Rev Ophthalmol, 2022, 46:  327-332)

Key words: diabetes retinopathy, inflammation, cytokines, vascular endothelial growth factor