45岁以上成年人前房容积测量及其在原发性闭角型青光眼筛查中的价值：北京眼病研究

doi:10.13281/j.cnki.issn.1004-4469.2021.04.002

眼科 ›› 2021, Vol. 30 ›› Issue (4): 259-264.doi: 10.13281/j.cnki.issn.1004-4469.2021.04.002

45岁以上成年人前房容积测量及其在原发性闭角型青光眼筛查中的价值：北京眼病研究

陈长喜王进达曹凯徐亮王亚星李建军

首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科研究所眼科学与视觉科学北京市重点实验室100005

收稿日期:2021-04-12 出版日期:2021-07-25 发布日期:2021-07-22
通讯作者: 李建军，Email：jianjunli2005@163.com
基金资助:
北京市属医学科研院所公益发展改革试点项目（2019-4）

Anterior chamber volume measurement and its value of screening primary angle-closure glaucoma in adults over 45 years old: The Beijing Eye Study

Chen Changxi, Wang Jinda, Cao Kai, Xu Liang, Wang Yaxing, Li Jianjun

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Key Laboratory of Beijing Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China

Received:2021-04-12 Online:2021-07-25 Published:2021-07-22
Contact: Li Jianjun, Email: jianjunli2005@163.com
Supported by:
Pilot Project of Public Welfare Development and Reform of Beijing Municipal Medical Reasearch Institutes (2019-4)

摘要/Abstract

摘要： 目的分析45岁以上成年人前房容积（anterior chamber volume，ACV）的测量结果及其对原发性闭角型青光眼（primary angle closure glaucoma，PACG）的筛查价值。设计横断面调查。研究对象 “北京眼病研究”2006年受试者3251例。方法采用前节相干光断层扫描（AS-OCT）测量受试者的ACV及其它眼前节参数。按屈光状态及年龄分组分析数据。采用Spearman秩相关分析ACV与其它眼前节参数的相关性，采用受试者操作特征曲线（receiver operating characteristic curve，ROC）评价ACV及其它眼前节参数对PACG的筛查价值；采用Delong检验对多条ROC曲线进行比较。采用Logistic回归探索患PACG的影响因素。主要指标 ACV值，ROC曲线下面积。结果 45岁以上人群ACV平均值为（132.07±32.66） mm3。男性ACV（139.77±33.15 mm3）高于女性（126.15±31.00 mm3）。45~54岁、55~64岁、65~74岁以及≥75岁人群ACV值分别为（143.23±31.25 ）mm3、（129.71±32.65） mm3、（123.71±30.56 ）mm3和（115.71±28.92） mm3。近视、远视者ACV值分别为（149.86±37.34） mm3、（113.39±26.84） mm3。PACG患者ACV值为（79.15±13.63 ）mm3。采用ACV前房深度、500 μm前房角角度筛查PACG的ROC曲线下面积分别为0.938、0.937、0.938。约登指数提示ACV用于筛查PACG的截断值为114.90 mm3。结论北京地区45岁以上人群ACV平均值为（132.07±32.66） mm3。 ACV随年龄增长而减小。近视者ACV较大。 ACV筛查PACG的能力与指标前房深度及500 μm前房角角度相当。当ACV低于115 mm3时提示患PACG的风险较大。（眼科， 2021， 30： 259-264）

关键词: 前房容积, 闭角型青光眼, 筛查效能, 横断面研究

Abstract: Objective To study the measurement results of anterior chamber volume (ACV) in adults over 45 years and its screening value for primary angle closure glaucoma (PACG). Design Cross-sectional survey. Participants 3251 subjects in the Beijing Eye Study 2006. Methods Heidelberg anterior segment optical coherence tomography (AS-OCT) was used to measure the subjects' ACV and other anterior segment parameters. The subjects were divided into different groups according to their refractive status and age for analysis. Spearman rank correlation analysis was used to explore the correlation between ACV and other anterior segment parameters. Receiver operating characteristic curve (ROC) was used to evaluate the value of ACV and other anterior segment parameters in PACG screening. Delong's test was used for comparison of multiple ROC curves. Logistic regression was used to explore the influencing factors of PACG. Main Measure Outcomes ACV, area under the ROC curve. Results The average ACV level of subjects over 45 years old was 132.07±32.66 mm3. The average level of ACV in men was 139.77±33.15 mm3, and 126.15±31.00 mm3 in women. The average ACV level of subjects aged 45~54, 55~64, 65~74 and ≥75 years old was 143.23±31.25 mm3, 129.71±32.65 mm3, 123.71±30.56 mm3 and 115.71±28.92 mm3, respectively. The average ACV levels of myopia, hyperopia subjects were 149.86±37.34 mm3 and 113.39±26.84 mm3. For subjects with PACG, the average ACV level was 79.15±13.63 mm3. When screening PACG, the area under the ROC curve of ACV, anterior chamber depth (ACD), 500 μm anterior chamber angle (ACA) is 0.938, 0.937, 0.938, respectively. According to Youden index, the cut-off value of using ACV to screen PACG is 114.90 mm3. Conclusion The average ACV level of people over 45 years old in Beijing area is 132.07±32.66 mm3. ACV gradually decreases with age. ACV of myopia population is larger. The ability of ACV to screen PACG is not weaker than that of ACA and ACD. ACV with lower than 115 mm3 indicates the higher risk of PACG. (Ophthalmol CHN, 2021, 30: 259-264)

Key words: anterior chamber volume, angle-closure glaucoma, screening efficacy, cross-sectional study

陈长喜王进达曹凯徐亮王亚星李建军 . 45岁以上成年人前房容积测量及其在原发性闭角型青光眼筛查中的价值：北京眼病研究[J]. 眼科, 2021, 30(4): 259-264.

Chen Changxi, Wang Jinda, Cao Kai, Xu Liang, Wang Yaxing, Li Jianjun . Anterior chamber volume measurement and its value of screening primary angle-closure glaucoma in adults over 45 years old: The Beijing Eye Study[J]. Ophthalmology in China, 2021, 30(4): 259-264.

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45岁以上成年人前房容积测量及其在原发性闭角型青光眼筛查中的价值：北京眼病研究

Anterior chamber volume measurement and its value of screening primary angle-closure glaucoma in adults over 45 years old: The Beijing Eye Study

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