Abstract:  Objective To explore risk factors of prognosis in eyelid sebaceous gland carcinoma (SGC). Design Retrospective case series. Participants 354 eyelid SGC patients with surgical treatment from 2006 to 2020 in Beijing Tongren Hospital. Method Medical records and follow-up data were reviewed. The tumor was graded by 8th American Joint Committee on Cancer (AJCC). Logistic regression was used to analyze the related factors of recurrence. Kaplan-Meier method and log-rank test was used for survival analysis. Main Outcome Measures Gender, age, habitation region, initial tumor location, size and classification of the tumor, duration of patient's complaints, recurrence and metastasis. Results 354 patients were with a mean age of 61.68±11.55 years and 212 cases (59.89%) were female. Upper eyelids were the most predilection sites of SGC with 214 cases (60.45%). The median duration time was 6.00 (3.00, 17.00) months before operations (range from 0.25~120 months). The classification of cases included T1 to T4 stage, with the number of 166 (46.89%), 129 (36.44%), 36 (10.17%) and 23 (6.50%), respectively. 68 patient relapsed with a rate of 19.21%. 3 of 22 metastasis patients died from the tumor. The 5-year metastasis rate was 4.69% (n=10), the 10-year metastasis rate was 7.98% (n=17), and the total metastasis rate was 10.33%. Older age (P=0.035) and severe AJCC stage (P=0.012) were the risk factors of recurrence. Conclusion The older the age and the higher grade of eyelid sebaceous gland carcinoma patients, the greater the chance of recurrence. （Ophthalmol CHN, 2022, 31: 104-108）

Key words:  , eyelid sebaceous gland carcinoma, prognosis, recurrence rate