Abstract: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare yet severe drug-induced mucocutaneous conditions, frequently presenting with acute and chronic ocular complications. Severe cases can result in blindness. The incidence of ocular involvement is high in patients during the acute phase, yet ocular conditions are often overlooked. Early diagnosis and aggressive anti-inflammatory treatment, including amniotic membrane transplantation, are crucial to mitigate damage and prevent severe late-stage complications, and enhance the quality of life for patients. This paper emphasizes the importance of early ophthalmic management in SJS-TEN, aiming to raise awareness of ocular complications, promote early diagnosis and intervention, reduce vision loss risk, and  improve the long-term quality of life for patients. (Ophthalmol CHN, 2024, 33: 245-248)

Key words: Stevens-Johnson syndrome, toxic epidermal necrolysis, dry eye, ocular surface injury