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Research team teaching method in ophthalmological practice FU Jing Ophthalmology in China    2015, 24 (4): 275-277.   DOI: 10. 13281/j. cnki. issn.1004-4469. 2015. 04. 014 Abstract （896）            Knowledge map    Save Research team teaching in ophthalmology is a task-oriented teaching method of ophthalmology, aiming to improve the research capacity of an academic research team. Every team member is encouraged to participate, and his role is rotated between teaching and learning. The teaching content is settled around the research project of ophthalmology, including experimental method, relevant theoretical knowledge, and project progression and quality control. Several forms of teaching-learning methods are included, such as one to one or one to many training, group meeting, reading club, and salon. Through those learning process, team members can develop their abilities needed for specific project, including the innovation ability, analyzing and problem-solving ability, thereby enhance the research efficiency and core competitiveness of the ophthalmological team. (Ophthalmol CHN, 2015, 24: 275-277) Related Articles | Metrics

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Comparision of the clinical efficacy of vitrectomy combined with cyclophotocoagulation and trans-scleral cyclophotocoagulation to treat secondary glaucoma ZHOU Dan, HE Lei, PANG Xiu-qin Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2016.05.011

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Inhibition of Akt activity enhances the sensitivity of retinoblastoma SO-Rb50 cell line to carboplatin in vitro ZHANG Hao1, WANG Yi-chen2, LI Bin2, YANG Su-hong1, GONG Yue-qiu1 Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2015.06.014

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Diagnosis and management of fungal infected optic neuritis TAN Shao-ying, XU Quan-gang, WEI Shi-hui, ZHAO Jie Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2017.03.012

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Practice of problem-based learning method in strabismus course for residents HONG Jie, FU Jing Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2016.02.020

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Strategy of management and implementation of international medical aiding program-taking Bright Jounery Program in Ghana as an example WANG Jia-wei1, WEI Xian-jing1, ZHOU Zi-xiao2, CHEN Jia-yong3, LIANG Xiao-song1, LIU Wei-ci1 Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2016.03.018

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Cultivation of clinical and scientific research ability for master degree candidates whose major in the ocular tumor and orbital disease MA Jian-min, LIU Xiao, MA Ke Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2016.05.017

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Clinical observation of changes in posterior corneal surface after transepithelial photorefractive keratectomy SU Yan, HOU Jie, ZHENG Xiu-yun, LEI Yu-lin Ophthalmology in China    2014, 23 (3): 161-164.   DOI: 10.13281/j.cnki.issn.1004-4469.2014.03.005 Abstract （1740）            Knowledge map    Save Objective To observe the changes of posterior corneal surface after transepithelial photorefractive keratectomy (T-PRK) and epipolis laser in situ keratomileusis (Epi-LASIK) for myopia. Design Prospective comparetive case series. Participants 134 eyes of 68 miopia patients were divided into T-PRK group (81 eyes) and Epi-LASIK group (53 eyes). Methods Posterior corneal elevation and Q-value were analyzed using pentacam before and 1 week, 1, 3 and 6 months after operation，respectively. Main Outcome Measures Posterior coneal elevation and Q-value. Results In the T-PRK group, at 1st and 6th month after surgery and in the Epi-LASIK group at 6th month after surgery, the posterior corneal elevation have a statistically significant backward displacement（all P＜0.05）. No statistically significant difference was found in the postoperative corneal Q-value in both groups before and after surgery（all P＞0.05）. There was also no statistically significant difference of postoperative corneal surface elevation and Q-value between the two groups （all P＞0.05）. Conclusion The posterior corneal elevation showing a backward displacement after T-PRK for myopia，while posterior corneal asphericity has no changed. Related Articles | Metrics

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Clinical diagnosis, treatment and efficacy of 97 cases of pediatric orbital cellulitis FAN Yun-wei, WU Qian, YU Gang, CAO Wen-hong, WANG Yuan, LIU Wen Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2015.06.012

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Take full advantage of clinical medical images in ophthalmic anatomy teaching PENG Xiao-yan, XU Zhang-xing Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2015.05.017

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Water drinking test influences intraocular pressure, axial length and choroid thickness in normal young adults ZHANG Hui,HONG Jie, HUO Yan-jiao, WANG Huai-zhou, WANG Ning-li. Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2017.01.008

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The effect of tear film function on the activity of primary pterygium  GAO Yang1, ZHOU Jin2, SUN Xiao-fang3. Ophthalmology in China    2015, 24 (1): 44-46.   DOI: 10.13281/j.cnki.issn.1004-4469.2015.01.012 Abstract （840）            Knowledge map    Save Objective To explore the effect of functional tear film on constitutional pterygium. Design Prospective comparative case series. Participants 53 cases of monocular patients with primary pterygium in Nanlang Hospital of Zhongshan City from August 2012 to February 2013. Method  14 pterygium patients with stationary phase and 39 patients with active phase were included in this study. All patients were examined  with Schirmer test, tear film break-up time (BUT) and conjunctival impression cytology for golblet cell count. Logistic regression was used to analyze associated factors and ptetygium activity.  Main Outcome Measures  Schirmer test, BUT and conjunctival golblet cell density. Results The result of Schirmer test in stationary phase and active phase was (9.43±2.28) mm and (8.67±2.14) mm, respectively (P=0.267). While the result of BUT in stationary phase and active phase was (8.79±1.97)s and (5.05±2.14)s, respectively (P=0.000). The mean globlet cell density (numbers/10 fields) in conjunctival impression specimens in stationary phase and active phase was (38.79±2.83) and (32.74±3.30), respectively (P=0.000). The logistic regression analysis showed that only BUT could affect the activity of ptetygium. Conclusions The active state of pterygium is associated with ocular surface status of patients. The patients of pterygiumms in active phase suffer poor tear film compared with patients in stationary phase. (Ophthalmol CHN, 2015, 24: 44-46) Related Articles | Metrics

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Study on human visual fatigue induced by watching linear polarized liquid crystal display and circular polarized liquid crystal display with eye tracker  ZHANG Li1, XU Liang1, ZHANG Yun-hong2, LI Jian-jun1. Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2016.01.013

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Effect of ultraviolet irradiation on the stability of tear film and corneal tissue of rats LIU Wei-yang，WU Xin-na, HUANG Yan，XIE Pin, CAI Xiang-heng, YAN Zhi-peng Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2017.02.007

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Retinal vessel oxygen saturation in Chinese healthy individuals YANG Jing-yan, YOU Bing, WANG Qian, ZENG Si-yan, WEI Wen-bin Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2016.05.013

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Clinical analysis of fungal keratitis in Xishuangbanna Autonomous Prefecture, Yunnan Province in 2004-2014 ZHAO Nan-nan1, WANG Li-tao2, JIN Jing2, ZHOU Qing2, LUO Ping2. Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2017.01.013

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Two novel mutations in Best vitelliform macular dystrophy GONG GONG Li-xue, GU Hong, LIU Shou-bin, LIU Ning-pu, MA Kai Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2017.03.011

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Second stage fixed to the ciliary sulcus of common capsular tension ring for moderate and severe lens subluxation CHEN Zhi-min1， ZHANG Wu-lin1， WU Wei-jing2， LIN Zhi-hui1， YANG Rong1. Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2016.02.002

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Ocular surface microbial distribution and clinical analysis of blepharitis GAO Rui, SUN Xu-guang, WANG Zhi-qun, ZHANG Yang Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2016.02.012

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Clinical characteristics and causes of laser-induced maculopathy CHEN Yan-yun, LI Ji-peng, LU Ning Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2017.03.014

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Application practice and exploration of workshop teaching method in ophthalmic surgical skills training in postgraduate students LI Dong-mei, ZHOU Jin-qiong Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2016.02.021

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Application of Accommodation Analyzer-1 on assessment of visual fatigue induced by watching 3D video ZHANG Li, XU Liang, WANG Xiao-bing, ZHAO Shi-qiang, LI Jian-jun Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2015.06.010

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Six-months result of minimally invasive phacotrabeculectomy in the treatment of patients with acute angle-closure glaucoma and coexisting cataract  HOU Xu, HU Dan, CUI Zhi-li, ZHOU Jian, CAI Li, WANG Yu-sheng. Ophthalmology in China    2015, 24 (1): 31-35.   DOI: 10.13281/j.cnki.issn.1004-4469.2015.01.009 Abstract （1249）            Knowledge map    Save 【Abstract】 Objective To study the effect of the application of minimally invasive phacotrabeculectomy in patients with unresponsive acute angle-closure glaucoma. Design Retrospective case series. Participants 15 cases（15 eyes）with acute angle-closure glaucoma and coexisting cataract in Xijing Hospital between March 2011 to March 2013. Methods Preoperative topical corticosteroids, mannitol, methazolamide and paracentesis were applied to reduce intraocular pressure (IOP). A standard phacoemulsification was performed, followed by minimally invasive trabeculectomy with a fornix-based conjunctival flap (5 mm) and small sclera flap (3 mm). Main Outcome Measures Visual acuity, IOP, anterior chamber depth, inflammatory reaction, and bleb-related complications. Results Pre-operative average IOP was (53.13±8.82) mmHg. One week after surgery the visual acuity of all patients was improved significantly, and the IOP was (13.41 ± 3.42) mmHg. 3 and 6 months after surgery IOP was (14.65±4.21) and (15.35±5.48) mmHg, respectively. Inflammation in the anterior chamber subsided postoperatively at one week, inflammatory exudate was almost absorbed, and anterior chamber depth was significantly deeper at two weeks, with an average of (2.72 ± 0.38) mm. All 15 eyes had diffuse blebs or elevated blebs with microcystic changes in the conjunctiva between 3 months to 6 months postoperatively. Postoperative vision acuity was (0.92±0.48) at 6 months. No serious adverse complications were encountered during follow-up. Conclusion Minimally invasive trabeculectomy could reduce tissue injury and improve the safety of surgery, which is an effective method when combined with phacoemulsification in the treatment of patients with unresponsive acute angle-closure glaucoma and coexisting cataract. (Ophthalmol CHN, 2015, 24: 31-34) Related Articles | Metrics

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Clinical characteristics and prognosis of cytomegalovirus retinitis with acquired immune deficiency syndrome  without anticytomegalovirus therapy SUN Hui-yu, MAO Fei-fei, LI Dan, WANG Sheng-nan, LIU Yue-hong, XU Xue-jing, LIU Bin-bin, DONG Yu Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2016.03.011

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Clinical features of 18 cases of ethambutol-induced optic neuropathy CAO Shan-shan1, PENG Chun-xia1, LI Xiao-ming2, ZHANG Xiao-hui3, WEI Shi-hui1 Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2016.02.013

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Protective effects of pentazocine on retinal Müller cells under high-glucose conditions CUI Le-le, WANG Yun-song, SHAN Ming-hua, ZHOU Yun-tao, TIAN Wei Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2016.03.004

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Investigation and analysis on the participant status of medical staff from primary hospital in a tele-ophthalmology project MA Yi1, 2, LI Jian-jun2, LIU Li-juan2, WANG Shuang2, LU Qing-jun2,3, XU Liang2, CHEN Juan1 Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2015.06.017

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Application of problem-based study combined with case-based study teaching mode in the education of postgraduate students WANG Jun, CAO Ying-xue, XU Liang Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2016.05.018

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The effects of recessive placement of spherical headed silicone tube for chronic dacryocystitis LU Jun-Hua, PAN Xue-Fei, ZHAO Mao-Zhu Ophthalmology in China    2014, 23 (2): 126-129.   DOI: 10.13281/j.cnki.issn.1004-4469.2014.02.013 Abstract （825）            Knowledge map    Save Objective To observe the clinical effects of the recessive placement of spherical headed silicone tube on treatment of chronic dacryocystitis. Design Retrospective case series. Participants 65 patients ( 67 eyes) with chronic dacryocystitis. Methods All the participants were accepted the operations of the recessive placement of spherical headed silicone tube. Using the method of probing of lacrimal passage, the traction line was sent into the inferior nasal meatus using the 8-pin, after the expansion of nasal tube using the expansion rope, the ball head silicone tube was tracted retrogradely guaided by the traction line and implanted. Then the lacrimal passages were washed with plus gentamicin and dexamethasone mixture and saline irrigation after the operation once a day in one week, after 1 week once a week, for 3 months, and the tube was removed three to six months after placing. The lacrimal passages were washed with antibiotic and hormone (about 4 times), the tube was injected with TobraDex after the tube was removed. The symptoms were observed in the following 3 months to 2 years.  Main Outcome Measures The symptom of epiphora and pus, the situation of lacrimal duct. Results After the tube planting,  the lacrimal duct system of totally 65 patients (67 eyes) were able to be irrigated successfully. 49 eyes（73.13%） were cured after the removal of silicone tube during the follow-up period, and the symptom of epiphora and pus disappeared, there were no serious intra- and post-operative complications. Conclusion Recessive placement of spherical headed silicone tube is an effective method for the most chronic dacryocystitis. (Ophthalmol CHN, 2014, 23: 126-129) Related Articles | Metrics Cited: Baidu(1)

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Irritant test of dihydroartemisinin ointment in rabbit eyes WANG Zhi-qun, ZHANG Yang, QU Jing-hao, ZHANG Xiao-yu, SUN Xu-guang Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2016.02.011

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Curative effects of lacrimal duct drill combined with lacrimal duct intubation on chronic dacryocystitis LIN Zai-xiong, WU Jiang, LI Ke, CHEN Zhi, LI Meng-en Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2017.06.004

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The effect of double incision joint nuclear extraction with two-dialer in extracapsular cataract extraction procedure for restoring-vision cataract projects YANG Li-dong, YANG Yun-dong, XU Shen Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2016.02.003

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Effects of a broad-spectrum mechanosensitive ion channels inhibitor ruthenium red on intraocular pressure FANG Jing-wang1, TIAN Li-ping2, LIU Ya-ni1, WU Shen3, ZHANG Jing-xue3, XIN Chen3, WANG Ning-li3, ZHU Wei1 Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2019.03.009

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Clinical characteristics and treatment effect in patients with facial rosacea combined ocular damage CHEN Ying-Xin, GAO Ming-Hong Ophthalmology in China    2014, 23 (2): 121-125.   DOI: 10.13281/j.cnki.issn.2014.02.012 Abstract （1174）            Knowledge map    Save Objective To investigate the clinical characteristics and treatment of facial rosacea with ocular damage. Design Retrospective case series. Participants Sixteen cases of facial rosacea with ocular damagewere enrolled from January 2010 to December 2012. The age range at presentation was between 16 and 56 years. Methods 16 cases of medical records were followed up for 12 months. In addition to gross inspecting rosacea lesions of the eyes and face, slitlamp and microscope were used to detect the subtle changes in the face and eyes, particular vascular abnormalities. Tests of tear production and tear breakup time (BUT) were performed in 12 patients with ocular dry sensation. Mites were checked on face and nasal skin, and microbiological examination and culture were performed on the palpebrals. Minocycline hydrochloride was used orally 50 mg, twice one day for 3 to 6 months. Topical corticosteroids (loteprednol suspension eye drop) and antibiotic (levofloxacin) were used 3 times one day until two weeks after ocular changes were negative. Main Outcome Measures Skin changes, ocular changes， Schirmer test and tear film BUT. Results Clinical features: common signs of facial skin showed erythema vasodilation hyperplasia in 16 patients (100%), conjunctival hyperemia and conjunctival vasodilation deformation or hyperplasia in 16 patients(100%), 14 cases (87.5%) of blepharoconjunctivitis and 12 cases (75%) of dry eye. Less common signs were including 4 cases (25%) of inferior corneal tongue and tree-like pannus, 6 cases (37.5%) of facial rhinophyma, 4 cases (25%) of corneal ulcers, 4 cases (25%) of episcleritis and two cases (12.5%) of iridocyclitis. After the medication treatment, skin and eye lesions of all the participants were significantly improved (100%). It showed that erythema of facial and nasal skin, and corneal pannus was subsided, corneal infiltrates and conjunctival hyperemia disappeared. Conclusion Atypical ocular clinical manifestations were often difficult to identify, vascular changes was the basis sign, facial vascular changes were often combined for diagnosis. And it was very effective to use minocycline hydrochloride combined with corticosteroid for facial rosacea with ocular damage. (Ophthalmol CHN, 2014, 23： 121-125) Related Articles | Metrics Cited: Baidu(2)

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Clinical observation of optic disc parameters and pRNFL thickness in tuberculum sellae meningiomas WANG Li-na, YANG Liu, QU Yuan-zhen Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2015.06.016

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Etiology and clinical characteristics of infantile cataract combined with vitreous abnormities MA Yan, LU Hai Ophthalmology in China    2015, 24 (2): 103-107.   DOI: 10.13281/j.cnki.issn.1004-4469.2015.02.008 Abstract （765）            Knowledge map    Save Objective To investigate clinical characteristics and etiology of infantile cataract combined with vitreous abnormalities. Design Retrospective and non-controlled case series. Participants From January 2013 to July 2014 at Beijing Tongren Eye Center eighty-four children (114 eyes) aged 3-year old or younger who were diagnosed as cataract and detected vitreous abnormality by ophthalmic color Doppler flow imaging (CDFI) ultrasound were enrolled. Methods Charts of these patients were reviewed. Age, chief complaints, signs, CDFI examination and suggested diagnosis, proven diagnosis, past history, family history, and pregnancy history of their mothers were recorded. Etiology and clinical characteristics were analyzed. Main Outcome Measures Age, symptoms, course, signs, CDFI manifestations and suggested diagnosis, proven diagnosis. Results Age at presentation varied from 0 to15 months (2.7±3.0 months). Age at diagnosis was 2~20 months (7.8±4.2 months). Abnormalities were noticed by parents in 81 cases (96.4%) and detected by eye examinations in 3 cases (3.6%). The first noticed symptoms were leukocoria in 39 cases (46.4%), unable to follow objects in 16 cases (19.0%), strabismus in 10 cases (11.9%), and binocular asymmetry in 7 cases (8.3%). The cataract was complete type in 75 eyes (65.8%), posterior polar type in 38 eyes (33.3%), and membranous type in 1 eye (0.9%). They could complicate with nystagmus, strabismus, microphthalmia, shallow anterior chamber, secondary glaucoma, persistent pupillary membrane, tractional retinal detachment and coloboma of choroid. CDFI suggested diagnosis included persistent hyperplastic primary vitreous (PHPV) in 111 eyes (97.4%), retinal detachment in 3 eyes (2.6%). Confirmed diagnosis after surgery included PHPV in 76 eyes (66.7%), family exudative vitreoretinopathy (FEVR) in 14 eyes (12.3%) and congenital cataract in 24 eyes (21.0%). CDFI suggested diagnosis and post-operative confirmed diagnosis were consistent in 69.3% cases. Conclusion Patients who were diagnosed as infantile cataract presumptively with abnormal vitreous were mostly at large month-old and mostly noticed as leukocoria by their parents, which could complicate with a variety of ocular abnormality. Pre-operative CDFI examination could detect vitreous and retinal disorders. (Ophthalmol CHN, 2015, 24: 103-107) Related Articles | Metrics

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Refractive changes after pharmacologic resolution of macular edema induced by retinal vein occlusion  WU Xi-shi,ZHENG Bin,LIN Li,SHEN Li-jun. Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2017.01.011

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Surgical approach and long-term outcome of uveal neurogenic tumor HUANG Yao, XU Xiao-lin, LI Bin, WEI Wen-bin Ophthalmology in China    DOI: 10.13281/j.cnki.issn.1004-4469.2017.03.010

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Reproducibility of parafoveal choroidal vessel layer thickness measurements with enhanced depth imaging by spectral-domain optical coherence tomography  ZHAO Jing, WANG Ya-xing, ZHANG Qi, LI Jian-jun, XU Liang. Ophthalmology in China    DOI: 10. 13281/j. cnki. issn.1004-4469. 2016. 01. 011

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Longitudinal study of ocular biometry parameters in schoolchildren: two years follow-up  GUO Yin1, TANG Ping1, LIU Li-juan2, XU Liang2, LV Yan-yun1, FENG Yi1, MENG Meng1. Ophthalmology in China    2015, 24 (1): 19-25.   DOI: 10.13281/j.cnki.issn.1004-4469.2015.01.007 Abstract （1089）            Knowledge map    Save Objective To assess the change and associated factors of ocular biometry parameters in schoolchildren of Beijing. Design School-based, longitudinal study. Participants 382 Grade-1 and 299 Grade-4 students from two schools participated in the study located in DongCheng District (urban) and HuaiRou District (rural). Methods Baseline study was conducted in 2011, and followed up in 2012 and 2013. Comprehensive eye examinations were same in three years, including visual acuity, ocular motility evaluation, auto-refraction, slit lamp, ocular biometry with Lenstar Biometer and non-mydriatic fundus. Participants were administered detailed questionnaires including nearwork, social-economic parameters and outdoor activity. Multivariate regression analysis was used to analyze the change of ocular biometry, axial length/corneal curvature, refraction and associated factors. Main Outcome Measures Parameters of ocular biometry and refraction degree. Results Mean spherical equivalent was  (-0.55±1.30) D at baseline. Mean axial length was (23.03±0.96) mm. Mean axial length/corneal curvature (AL/CC) was (2.94±0.11). In 2012 and 2013, progression of refraction was (-0.07±0.88) D and (-0.62±1.03) D. Elongation of axial length was (0.26±0.49) mm and (0.32±0.92) mm. An increase in myopic refractive error, after adjustment for age, was significantly associated with less time spent outdoors for leisure (P=0.006), less total time spent outdoors (P=0.04), or more time spent indoors with studying (P=0.005). Elongation of axial length was significantly associated with less total time spent outdoors (P=0.02) and more time spent indoors with studying (P=0.007) after adjustment for maternal myopia (P=0.02). An increase in AL/CC was significantly associated with less time spent outdoors (P=0.01) after adjustment for paternal myopia (P=0.003). Conclusions Progression of myopia, elongation of axial length and change of AL/CC in schoolchildren of Beijing were associated with older age, urban region of habitation, parental myopia, more indoor studying and less outdoor activity after two years follow up. The study provides more evidence in myopia risk factors research. (Ophthalmol CHN, 2015, 24: 19-24) Related Articles | Metrics