关键词:  , 获得性免疫缺陷综合征, 巨细胞病毒, 视网膜炎, 病毒性, 葡萄膜炎, 免疫恢复性, CD4+T细胞

Abstract: 【Abstract】 Objective To investigate characteristics of cytomegalovirus retinitis and immune recovery uveitis in AIDS patients．Design Retrospective cases series. Participants 32 patients with active cytomegalovirus retinitis in Department of Ophthalmology, Beijing You’an Hospital. Methods All 32 patients were evaluated with general and ophthalmic examinations and the clinical characteristics were analyzed． 32 patients underwent ophthalmologic examinations that included visual acuity, anterior segment, fundus examinations, fundus fluorescein angiography (FFA) and immunology related examinations. Main Outcome Measures Vision acuity, intraocular pressure (IOP), fundus examinations and CD4+T cell counts. Results In all 32 patients with cytomegalovirus retinitis, visual acuity varied from light perception to 1.0; and their IOP varied from 8 to 16 mm Hg. Eight patients had anterior uveitis. All of the patients had typical cytomegalovirus retinitis. 8(25%) patients whose CD4+T cell counts＜10 per/μL had visual acuity varying from light perception to 0.8，3 of whom had immune recovery uveitis. One of them had retinal detachment. 15(46.88%) patients whose CD4+T cell counts were 10～50 per/μL. Their visual acuity varied from finger counting to 0.8. One of them had immune recovery uveitis. One of them had retinal detachment. 9（28.12%） patients had CD4+T cell counts＞50 per/μL, none of them had retinal detachment or immune recovery uveitis. 19 patients (including 4 paients with immmune recovery uveitis) had complicated with other opportunistic infections． Conclusion The patients whose CD4+T cell were no more than 50 per/μL were easy to have cytomegalovirus retinitis. The patients whose CD4+T cell counts＜10 per/μL were liable to have immune recovery uveitis and other opportunistic infections. (Ophthalmol CHN, 2012, 21: 405-408)

Key words: acquired immunodeficiency syndrome, cytomegalovirus retinitis, immune recovery uveitis, CD4+T cell