关键词:  , 帕瑞昔布钠；眼内容剜除术；义眼座植入手术；术后镇痛

Abstract: Objective  To investigate the postoperative analgesic effects of parecoxib sodium on the surgery of evisceration with implantation． Design Randomized controlled clinical trial. Participants Continuous 60 patients undergoing evisceration with implantation surgery under general anesthesia in department of ophthalmology, Eye and ENT Hospital, Fudan University. Methods Sixty patients undergoing evisceration with implantation surgery under general anesthesia were randomly divided into 2 groups of thirty: Group A received parecoxib sodium 40 mg by intravenous injection before anesthesia induction and before the end of surgery. Parecoxib sodium 40 mg was also administrated by muscle injection twice a day in the next two days postoperatively. Group B received 2 ml saline by intravenous injection or by muscle injection at the same time. Visual analog score (VAS) was recorded to evaluate postoperative pain at the time of analepsia  (T1), 4 h(T2), 24 h(T3) and 48 h(T4) after the surgery. Side effects of parecoxib sodium were also recorded. Main Outcome Measures Visual analog score, side effects. Results The VAS scores at T1-T3 in Group A were 1.83±0.70, 1.17±0.65, 0.93±0.58. The VAS scores at T1-T3 in Group B were 2.87±1.04, 2.30±0.92, 1.40±0.62. The VAS scores in Group A were significantly lower as compared with those in Group B(all P<0.05). There was no significant difference of VAS score between Group A and Group B at T4(0.57±0.50 in Group A and 0.67±1.57 in Group B, P>0.05). No serious side effects were observed during the use of parecoxib sodium. Conclusion Administration of parecoxib sodium can provide good analgesia effects during early period after the surgery of evisceration with implantation. (Ophthalmol CHN, 2013, 22: 351-353)

Key words: parecoxib sodium, evisceration, implantation surgery, postoperative analgesia