Abstract: Objective To analyze clinical features of patients with retinitis pigmentosa (RP). Design Retrospective case series. Participants 393 patients with RP who consulted in Beijing Tongren Eye Center between January 2007 and May 2014. Methods Basic characterization, clinical history and clinical manifestations of 393 RP patients were reviewed. Main Outcome Measures Age of onset, clinical features of anterior and posterior segment of the eye and complications. Results RP generally affects bilaterally (98.0%) without gender preference (M:F=1:0.98). Blurred vision (78.4%) and night blindness (86.5%) were typical complaints. Most patients were myopia (52.2%) with best corrected visual acuity (Snellen) ranged from 0.1 to 0.6 (55.5%). Posterior subcapsular cataract (16.5%) was a common complication. Optic disc pale (40.9%), generally narrowing of retinal artery (57.1%) and vein (56.9%), and pigment disposition were main fundus findings. Osteoblast like pigment (63.6%) was the most common type and located diffusely (64.5%). Some patients also had choroid atrophy (32.9%) and macular epiretinal membrane (30.3%). Typical RP (58.9%) was the most common type with non-pigment RP (12.6%) secondly. Conclusion Clinical features of RP may vary greatly. Besides optic atrophy, narrowing of retinal vessels and pigmentation deposition, RP may have other manifestations and complications in both anterior and posterior segment of the eye.

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 retinitis pigmentosa, osteoblast like pigment