Table of Content

25 November 2021, Volume 30 Issue 6

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Pay attention to the diagnosis and treatment of dry eye related to infectious diseases

Jie Ying, Ruan Fang,

2021, 30(6):  409-411.  doi:10.13281/j.cnki.issn.1004-4469.2021.06.001

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In recent years, the incidence of various infectious diseases in our country is high, among which chronic infections of hepatitis C virus and human immunodeficiency virus are related to dry eye. With the development of treatments for hepatitis C and acquired immunodeficiency syndrome (AIDS), the prolonged life span of patients has increased the demands for the quality of life of patients. Ocular surface diseases such as dry eye, which were easily covered by blinding vitreoretinal diseases in the past, should also attract the attention of ophthalmologists and infectious disease physicians to provide standardized diagnosis and treatment for dry eye patients with infectious diseases. (Ophthalmol CHN, 2021, 30: 409-411)

Development and validation of a 6-gene signature model for predicting the risk of metastasis in uveal melanoma based on bioinformatic analysis

Yan Ran, Gao Xinxiao, Xie Pinxue, Zhu Siquan

2021, 30(6):  412-420.  doi:10.13281/j.cnki.issn.1004-4469.2021.06.002

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Objective To identify the biomarkers of metastatic uveal melanoma (UM) and develop a predictive model for the risk of metastasis in UM patients. Design Case control study and diagnosis test. Participants The transcriptome data of UM samples were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. Methods To analyze the differentially expressed genes in metastatic UM samples based on the transcriptome data UM samples obtained from the public database. To construct and validate a gene signature for predicting the risk of metastasis according to the differentially expressed genes. The differential expressed genes in metastatic UM tumor tissues were analyzed based on GSE21138 and GSE44299 data sets. The samples in GSE21138 were used as the training set. Lasso-Cox regression analysis was employed to construct a gene signature for predicting metastasis-free survival in UM patients. The receiver operating characteristic curves for predicting 1-, 3- and 5-year metastasis-free survival were generated. The Kaplan-Meier analysis was used to explore the predictive value of prognosis in patients at different risk group. Finally, the predictive value of gene signature is also validated in GSE44299 data set and TCGA database. Main Outcome Measures The differentially expressed genes between metastatic and non-metastatic UM tissues. The predictive value of the constructed gene signature for predicting metastasis-free survival, metastasis related death, overall survival and disease-specific survival in UM patients. Results A total of 17 differentially expressed genes (Fold Change＞2) were identified in metastatic UM samples. A 6-gene signature was developed by Lasso-Cox regression analysis for predicting metastasis-free survival including (RIMS2, PTP4A3, HTR2B, HNMT, COBLL1, ID2). The AUC values of 1-, 3- and 5-year metastasis-free survival predicted by the 6-gene signature were 0.78, 0.89 and 0.85, respectively. The results of Kaplan-Meier survival analysis showed that patients in high-risk group based on 6-gene signature risk score had unfavorable metastasis-free survival. The 6-gene signature also showed good predictive value for overall survival and disease-specific survival in the GSE44299 data set and TCGA database. Conclusion A 6-gene signature model based on UM metastasis related genes was developed and validated. The 6-gene signature has good predictive value for metastasis-free survival, overall survival and disease-specific survival in UM patients. (Ophthalmol CHN, 2021, 30: 412-420)

Analysis of aqueous humor virus type in patients with viral anterior uveitis

Shen Lin, Wang Hong, Zhao Meng, Wei Wenbin

2021, 30(6):  421-424.  doi:10.13281/j.cnki.issn.1004-4469.2021.06.003

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Objective To retrospectively analyze the aqueous humor virus of 25 patients with viral infectious anterior uveitis (AU). Design Retrospective case series. Participants 25 cases (25 eyes) of AU who were clinically suspected of viral infection. Methods All patients were record the history of viral infection, and performed serum immunological examinations, routine eye examinations (including visual acuity, intraocular pressure (IOP), slit lamp, indirect ophthalmoscope examination, etc.), and detected aqueous virus by real-time (RT-PCR) technology. Logistic regression analysis was used to evaluate the relationship between clinical manifestations and positive virus detection by PCR. Main Outcome Measures RT-PCR virus detection. Results 12 patients (48%) had a history of viral infection, and 7 patients (28%) had a history of overwork. RT-PCR was positive in 14/25(56%), and the positive of VZV, HSV1/2 and CMV was 9/25(36%), 4/25(16%) and 1/25(4%), redpectively. 19 eyes (76%) were sensitive with anti-virus therapy. Corneal edema（OR=2.006，P=0.043）, high IOP (OR=1.905，P=0.013) and pigmented KP (OR=1.31，P=0.014) or fine KP (OR=1.41，P=0.014) were significantly related with PCR positivity. Conclusion The detection of aqueous humor virus by RT-PCR has a good application value in the diagnosis of viral infectious anterior uveitis. Corneal edema, high IOP, pigmented KP or tiny gray white KP are associated with viral infection of anterior uveitis. (Ophthalmol CHN, 2021, 30: 421-424)

Quantitative optical coherence tomography angiography characteristics and relation with vision and course of disease in non-arteritic anterior ischemic optic neuropathy

Zhang Qiuyang, Zhao Yue, Yao Jin, Jiang Qin

2021, 30(6):  425-429.  doi:10.13281/j.cnki.issn.1004-4469.2021.06.004

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Objective To observe the characteristics in non-arteritic anterior ischemic optic neuropathy (NA-AION) using optical coherence tomography angiography (OCTA), and investigate the relation with course of disease and visual prognosis. Design Retrospective case series. Participants 24 eyes (24 cases) of NA-AION in Eye Hospital affiliated to Nanjing Medical University from January to June 2019. Methods At the baseline, one month and six months, comprehensive ophthalmologic examinations were performed, including best corrected visual acuity (BCVA) (LogMAR) and OCTA. The characteristics of (BCVA) (LogMAR) and the average retinal nerve fiber layer (RNFL) thickness and the vessel flow density of radial peripapillary capillary (RPC) with different courses of disease were compared, and related factors were analyzed with BCVA (LogMAR) and course of disease. Main Outcome Measures BCVA (LogMAR), RNFL thickness, vessel flow density of RPC. Results Compared with the control group（108.67±3.02 μm）, the RNFL thickness of NA-AION group（315.76±21.45 μm） was significantly thicker, and the vessel flow density of RPC was lower at baseline, the difference were statistically significant (all P<0.05). Compared to the eyes with disease duration≤7 days, there were more significant differences in the vessel flow density of RPC between ischemic and non-ischemic areas in the eyes with disease duration>7 days (P<0.05). The BCVA (LogMAR) was improved at 1 month and 3 months after onset, but there was no significant difference in BCVA (LogMAR) between 1 month and 3 months (P=0.329). Compared with the baseline, the RNFL thickness and the vessel flow density of RPC were decreased gradually at 1 month and 3 months the differences were statistically significant (P<0.05). The BCVA (LogMAR) was significantly positively correlated with RNFL thickness and the vessel flow density of RPC (r= 0.527, 0.550; P<0.05). Conclusion We can observe the change of optic disc RNFL thickness and the vessel flow density of RPC in NA-AION by OCTA, and the visual prognosis is significantly correlated with RNFL thickness and the optic disc vessel flow density. (Ophthalmol CHN, 2021, 30: 425-429)

Short-term effect of systemic glucocorticoid on visual field in patients with non-arteriticanterior ischemic optic neuropathy

Chen Wenyu, Ai Ming, Chen Ting

2021, 30(6):  430-434.  doi:10.13281/j.cnki.issn.1004-4469.2021.06.005

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Objective To investigate the short-term effect of systemic glucocorticoid therapy on visual field in patients with non-arteritic anterior ischemic optic neuropathy (NA-AION). Design Retrospective case series. Participants 56 patients (98 eyes) with NA-AION were enrolled from Renmin Hospital of Wuhan University from December 2016 to March 2021. Methods The patients were divided into glucocorticoid group (73 eyes) and control group (25 eyes) according to whether they agreed to treated with systemic glucocorticoid. The visual field was examined before and within 1 month after treatment. According to the improved glaucoma staging system (GSS2), the visual field defect degree of the affected eyes was divided into S0, border, S1, S2, S3, S4 and S5. All patients were given compound anisodine hydrobromide injection and mecobalamin tablets to improve circulation and cellular nutrition. At the same time, the glucocorticoid group was given glucocorticoid pulse therapy (intravenous methylprednisolone 500~1000 mg) once a day. After continuous use for 3 days, it was reduced as appropriate. After 5~7 days, it was changed to oral prednisolone (1 mg/kg/d), and gradually reduced (10 mg every 3 days) until the drug was stopped. After treatment, the patients whose visual field defect degree increased by stage and more than 1 stage were the patients with effective treatment, and the ratio of the patients with effective treatment to the total patients in the group was the effective rate. Visual field index (VFI), mean defect (MD), pattern standard deviation (PSD), visual field defect stage before and after treatment, and effective rate of treatment were compared between the two groups. Main Outcome Measures VEI, MD, PSD, visual field defect stage and effective rate of treatment. Results There was no significant difference in VFI and MD between glucocorticoid group and control group within 1 month after treatment [(57.62±24.40)% vs (60.28±28.67)%, t=0.450, P=0.654; (-14.70±7.21) dB vs (-14.20±9.06) dB, t=-0.280, P=0.780), while the difference of PSD was statistically significant [(9.19±3.87) dB vs (7.37±3.20) dB, t=2.112, P=0.037). The pre-posttreatment VFI difference, MD difference and PSD difference between glucocorticoid group and control group was not statistically significant [(8.38±15.976)% vs. (6.24±17.290)%, t=0.567, P=0.572; (2.04±4.71)dB vs (1.66±5.07) dB, t=0.338, P=0.736; (0.38±2.60) dB vs (-0.04±2.46) dB, t=0.713, P=0.736). After treatment, there was no significant difference in the staging of visual field defect between the glucocorticoid group and the control group (Z=-1.423, P=0.155), and there was no significant difference in the effective rate of treatment (27.40% vs 36.00%, χ2=0.724，P=0.696）. Conclusion Systemic glucocorticoid therapy can not improve the short-term visual field prognosis of NA-AION patients. (Ophthalmol CHN, 2021, 30: 430-434)

Long-term efficacy of ab externo microcatheter-assisted trabeculotomy for primary open-angle glaucoma

Liu Yan, Wang Huaizhou, Kang Mengtian

2021, 30(6):  435-439.  doi:10.13281/j.cnki.issn.1004-4469.2021.06.006

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Objective To evaluate the long-term efficacy and safety of ab externo microcatheter-assisted trabeculotomy (MAT) for primary open-angle glaucoma (POAG). Design Retrospective case series. Participants Consecutive 47 patients (63 eyes) with POAG who underwent ab externo MAT from October 2015 to May 2018 by a single surgeon in Beijing Tongren Eye Center. Methods Patients were followed before and 1, 3, 6 months, 1, 2, 3, 4, 5 years after surgery. Intraocular pressure (IOP) and usage of anti-glaucoma medication were compared between before surgery and last visit after surgery. Surgical success was defined as a postoperative IOP of ≤21 mmHg with (qualified success) of without (complete success) the use of anti-glaucoma medication. According to anti-glaucoma surgery history the patients were divided into two groups and compared IOP and usage of medication between two groups. Main Outcome Measures IOP, number of anti-glaucoma drops, surgery successful rate, and the complications. Results The pre-operative IOP was (24.8±9.0)mmHg, and post-operative IOP was（16.9±4.7）（P=0.000）. And the pre-operative number of anti-glaucoma drops was (2.9±0.9), post-operative was （0.7±1.0）（P=0.000）. The 1-, 3-, and 5-year cumulative rate of complete success was 72.1%, 62.7% and 41.2%, and those of qualified success was 91.8%, 88.1% and 76.5%, respectively. Hyphema was seen in all eyes and part of patients had transient IOP fluctuation in early postoperative days. There were no severe complications occurred in long-term follow-up. The last follow-up IOP with and without anti-glaucoma surgery history was repectively (18.1±5.1) mmHg and (15.7±4.0) mmHg（P=0.098）. Anti-glaucoma surgery history did not affect the surgery results. Conclusion Ab externo MAT has long-term effectiveness and safety for POAG. Previous anti-glaucoma surgery does not affect the results of MAT surgery. (Ophthalmol CHN, 2021, 30: 435-439)

Epidemiological characteristics of acute glaucoma in emergency clinic

Qiao Chunyan, Kang Mengtian, Zhang Hui, Li Jian, Cao Kai

2021, 30(6):  441-446.  doi:10.13281/j.cnki.issn.1004-4469.2021.06.007

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Objective To investigate the epidemiological characteristics and treatment outcome of acute glaucoma. Design Prospective case series. Participants 205 consecutive cases (230 eyes) of acute glaucoma visited in Beijing Tongren Hospital emergency room from October 23, 2018 to October 22, 2019. Methods The demographic information, initial and confirmed diagnosis, time of visit, treatment outcome were collected from the Hospital Information System (HIS) of Beijing Tongren Hospital and customized CRF. The rank sum test, the chi-square test and Fisher exact test were used for statistically analyze. Main Outcome Measures Demographic information, time of visit, diagnosis and disease proportion of all kinds of glaucoma, treatment and visual prognosis after follow up at least 1 year. Results In 205 cases (230 eyes), the majority of subjects were from Beijing (72.7%) and female (63.4%), and the mean age was 61.7±13.8 years（9～89）， 60~69 years old were the most（41.5%）. The mean presenting IOP was 46.4±11.8 mmHg. Acute primary angle-closure glaucoma (APACG, n=132, 64.4%) was the most common diagnosis，followed by secondary glaucoma (n=59, 28.8%). The diagnostic agreement between emergency ophthalmologist and glaucoma specialist was 88.8%, the main misdiagnosis came from secondary glaucoma due to subluxation of lens. With medical therapy, APACG attacks resolved within 2 hours in 85 cases (64.4%), but medical treatment was unable to break the initial acute attack of 18 cases (66.7%) secondary glaucoma due to lens subluxation. Winter had higher incidence of acute high IOP attack than other seasons (χ2=219.769, P<0.001). The proportion of blindness and low vision in the last follow-up were 12.2% (n=25) and 8.3% (n=17), respectively. Conclusion Emergency glaucoma patients are mainly primary angle-closure glaucoma. Midwinter and midsummer are high seasons. Glaucoma secondary to lens subluxation is easily misdiagnosed as APACG, and the effect of medication is not good enough. 20.5% of low vision or blindness after active treatment. (Ophthalmol CHN, 2021, 30: 441-446)

Levels of IL-1β and IL-1Ra in aqueous humor and serum of patients with proliferative diabetic retinopathy

Lin Zhong, Niu Tongtong, Du lin, Zhang Chenxi, Zhang Shaodan, Wang Hailin

2021, 30(6):  449-452.  doi:10.13281/j.cnki.issn.1004-4469.2021.06.008

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Objective To explore the level changes of interleukin-1β (IL-1β), interleukin-1 receptor antagonist (IL-1Ra), and vascular endothelial growth factor (VEGF) in aqueous humor and serum of patients with proliferative diabetic retinopathy (PDR). Design Prospective comparative case seiries. Participants 36 PDR patients and 26 cataract patients without diabetes (control group) were enrolled. Methods The peripheral blood and undiluted aqueous humor (operatively) of all patients were collected. The cytokine concentrations of aqueous humor and serum were analyzed by immune multiplex bead-based assay. The general information and cytokine concentration were compared between the two groups. The correlation analyses were also performed for the cytokines concentration of aqueous humor and serum. Main Outcome Measures The concentrations of IL-1β, IL-1Ra, VEGF in aqueous humor and serum. Results Both the concentration of IL-1β (6.7±4.3 pg/ml) and IL-1Ra (657.9±445.6 pg/ml) of aqueous humor in PDR group were higher than that in control group (3.3±3.2 pg/ml and 300.8±368.0 pg/ml, both P=0.001). The concentration of IL-1β (7.6±4.6 pg/ml) and IL-1Ra (437.8±270.2 pg/ml) of serum in PDR group were also higher than that in control group (4.9±3.7 pg/ml and 279.2±226.7 pg/ml, both P=0.02). There was no significant difference for the concentration of VEGF of aqueous humor and serum between the two groups. The concentration of IL-1β of aqueous humor or serum was highly and positively correlated with the concentration of IL-1Ra of the same sample. The concentration of IL-1β (r=0.50, P=0.003) and IL-1Ra (r=0.66, P<0.001) of aqueous humor was positively correlated with that of serum, respectively, in PDR group. However, there was no correlation for concentration of VEGF of aqueous humor and serum (r=-0.06, P=0.72). Conclusion The anti-inflammation cytokine compensatively increases as the inflammation cytokine increases in both aqueous humor and serum in patients with PDR. The regulation of this inflammation response may represent a novel modality in the treatment of diabetic retinopathy. The levels of inflammation and anti-inflammation cytokines may be used as biomarkers for diabetic retinopathy. (Ophthalmol CHN, 2021, 30: 449-452)

Effect of intravitreal triamcinolone acetonide on surgical efficacy of idiopathic epimacular membrane

Yao Yimin, Chai Xinan, Wei Yuhua, Wang Caixia, Shang Qingli, Ye Cunxi

2021, 30(6):  453-456.  doi:10.13281/j.cnki.issn.1004-4469.2021.06.009

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Objective To observe and analyze the effect of intravitreal triamcinolone acetonide (IVTA) on the anatomical structure and visual function of the macular area after the operation of idiopathic anterior macular membrane (IMEM). Design Case-control study. Participants 74 patients (74 eyes) with IMEM underwent surgery in the Second Hospital of Hebei Medical University from January 2017 to December 2019. Methods The patients were randomly divided into vitrectomy combined with IVTA group (38 cases, 38 eyes) and vitrectomy group (35 cases, 35 eyes). Vitrectomy was performed to remove the epimacular membrane and internal limiting membrane in the two groups, and IVTA 2 mg/0.05 ml was performed in IVTA group. The patients were followed up for at least 12 months. The best corrected visual acuity (BCVA), macular fovea thickness (CMT), ectopic inner foveal layers (EIFL) + outer plexiform layer thickness and intraocular pressure（IOP） were observed before and 1, 3, 6 and 12 months after operation. Pearson correlation analysis, multiple linear regression equation and generalized estimation equation were used for statistical analysis. Main Outcome Measures BCVA, CMT, EIFL+outer plexiform layer thickness. Results The preoperative BCVA was closely related to the thickness of EIFL+ outer plexiform layer (r=0.934, P=0.005). The BCVAs of IVTA group and the control group were significantly improved after operation (χ2=3428.83，P＜0.001； χ2=445.67，P＜0.001）； At 3, 6 and 12 months after operation, the difference of BCVA between the two groups was statistically significant (χ2=8.31，P=0.004； χ2=11.31，P=0.001； χ2=22.54, P<0. 001). The BCVA of the IVTA group was significantly better than that of the control group. The CMT of IVTA group and the control group were significantly decreased after surgery (χ2=1121.82，P<0.001; χ2=355.92，P<0.001）. There was significant difference in CMT between the two groups at 3, 6 and 12 months after operation (χ2=12.47，P＜0.001； χ2=21.15，P＜0.001； χ2=28. 88, P＜0. 001). The CMT in the IVTA group was significantly lower than that in the control group. The EIFL+outer plexiform layer thickness of IVTA group and the control group decreased significantly after operation (χ2=842.68，P<0.001; χ2=246.40，P<0.001）. At 3, 6 and 12 months after operation, there was significant difference in EIFL+outer plexiform layer thickness between the two groups (χ2=11.25，P=0.001； χ2=15.93，P＜0.001； χ2=11.98, P=0. 001). The EIFL+outer plexiform layer thickness in the IVTA group was significantly lower than that in the control group. Conclusion IVTA at the end of surgery can assist in the recovery of macular anatomy and visual function after vitrectomy in patients with idiopathic epimacular membrane. (Ophthalmol CHN, 2021, 30: 453-459)

Efficacy of air tamponade combined with vitrectomy for high-myopic patients with non-macular rhegmatogenous retinal detachment

Zhuang Jingjing, He Yongning, Luo Wei

2021, 30(6):  459-464.  doi:10.13281/j.cnki.issn.1004-4469.2021.06.010

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Objective To study the efficacy of air tamponade combined with vitrectomy in the treatment of high-myopic eyes with non-macular rhegmatogenous retinal detachment (RRD). Design Retrospective case series. Participants Fifty-six high-myopic patients with non-macular RRD who underwent pars plana vitrectomy（PPV） from May 2017 to February 2021 in Nanjing Aier Hospital. Methods Best corrected visual acuity (BCVA), non-contact intraocular pressure (NCT), slit lamp microscope, indirect funduscopy with slit lamp, wide-angle fundus photography, optical coherence tomography (OCT), ophthalmic AB ultrasound examination and length of optic axis with IOL-Master were performed before surgery and postoperative follow-up. All patients underwent 23-gauge PPV, and then 36 patients (air group) were filled with air and 20 patients (silicone oil group) were filled with silicone oil. The follow-up time was 5 days, 3 weeks and 3 months. Initial retinal attachment rate, BCVA and complications were compared between the two groups. Main Outcome Measures Initial retinal attachment rate, BCVA and NCT. Results All patients got retinal attachment during the 5-day and 3-week follow-up. Local retinal redetachment occured in one patient of the air group at the second month after surgery, and got final reattachment after scleral buckling. Initial reattachment was achieved 97.2%. One patient in silicone oil group experienced localized tetinal redetachment due to proliferative tractions, and got retianl reattachment after the second surgery of silicone oil tamponade. After surgery, all patients gained higher BCVA at 5 days, 3 weeks and 3 months after surgery than before surgery（t=5.663, 3.014, -2.934 in air group, P＜0.05; and t=-4.692, -2.629, -1.872 in silicone oil group, P＜0.05）. BCVA of air group was better than that of silicone oil group at 5 days and 3 weeks after surgery（t=1.547, -1.789, all P＜0.05）, but after 3 months the BCVA between the two groups showed no difference（t=1.285，P=0.051）. Increased NCT were found in one patient on the first day and one patient on the third week postoperatively in air group. In silicone oil group, 1 patient, 3 patients, 3 patients and 4 patients got increased NCT at 1 day, 5 days, 3 weeks and 3 months respectively. Conclusion Air tamponade combined with vitrectomy can treat high-myopic patients with non-macular RRD (under PVR C3) cost-effectively. It is also a selective method for those with choroidal detachment, to effectively reduce the application of silicone oil. (Ophthalmol CHN, 2021, 30: 459-464)

Effect of different orientation of acellular dermal allografts as covering material on hydroxyapatite orbital implantation

Qin Yi, Zhou Jun, Wang Cong, He Lei, Zheng Pengfei, Li Qiyan, Shi Xiangyu

2021, 30(6):  465-468.  doi:10.13281/j.cnki.issn.1004-4469.2021.06.011

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Objective To investigate the effect of acellular dermal allografts with different orientation as covering material in hydroxyapatite orbital implantation. Design Case control study. Participants Twenty patients (20 eyes) with acellular dermal allografts covering hydroxyapatite orbital implantation in Beijing Tongren Eye Center. Methods The patients were randomly divided into two groups. In the first group （basement outside group）, 10 patients were implanted with acellular dermal matrix with the basement membrane facing outward when covering the hydroxyapatite orbital implantation; in the second group of 10 patients（derma outside group）, the derma surface outward. All patients were followed up for 24 weeks. The clinical evaluation of outcome and complications were compared between the two groups. Main Outcome Measures Clinical evaluation of outcome and complications, including regression time of conjunctival edema, healing of conjunctival wound, shrinkage or not of conjunctival sac and subconjunctival graft of acellular dermal allograft. Results The grafts were well tolerated, with no cases of infection or explanation in the two groups. The regression time of conjunctival edema was 13.1±1.79 days and 12.8±1.93 days in the basement outside group and derma outside group, respectively (t=0.355，P>0.05). There was no obvious narrowing of conjunctival sac found; and all subconjunctival grafts showed white and dense in the two groups. The conjunctival wound healed well, without postoperative complications (including infection, hematoma, incision nonunion, acellular dermal allografts necrosis, orbital implantation exposure, etc.), and no secondary surgery (including debridement, repair and removal) in the two groups. Patients of the two groups were all prothesis 4 weeks after the operation, and the effect was satisfactory. Conclusion Acellular human dermis is an excellent barrier and covering grafting material in hydroxyapatite orbital implantation, and possesses excellent handling properties without needing to distinguish the orientation. (Ophthalmol CHN, 2021, 30: 465-468)

Practice and satisfaction survey of online teaching management mode in ophthalmology postgraduate and residential education

2021, 30(6):  470-473.  doi:10.13281/j.cnki.issn.1004-4469.2021.06.012

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Objective To study the satisfaction of online teaching management mode in ophthalmology postgraduate and residential education in medical colleges and universities. Design Questionnaire. Participants 125 professional master's degree students and resident students of grades 2017 and 2018 in Harbin Medical University. Methods The design and practice method of online teaching in ophthalmology department of Harbin Medical University were introduced. The online teaching videos were provided to the students through the video software, and the quality of online teaching through questionnaire survey were performed. Main Outcome Measures Satisfaction degree of students. Results 72% of students use pads and 8% use computers for online learning. 64% of the students prefer online teaching better, 32% of the students prefer face to face teaching better. 72% of the students prefer the reasonable length of online teaching time should be between 1 and 2 hours. More than 90 percent of students showed they prefer to continue receiving online teaching after the epidemic of COVID-19. Conclusion The satisfactory degree of online teaching management mode is well-pleasing in ophthalmology postgraduate and residential education in medical colleges and universities. (Ophthalmol CHN, 2021, 30: 470-473)