Most Down Articles

    Published in last 1 year| In last 2 years| In last 3 years| All| Most Downloaded in Recent Month | Most Downloaded in Recent Year|

    Published in last 1 year
    Please wait a minute...
    For Selected: Toggle Thumbnails
    The progress of diagnosis and treatment of malignant glaucoma
    Zheng Xuanli, Lin Haishuang, Li Jiaqian, Lei Changrong, Wan Rui, Ye Wenqing, Liang Yuanbo
    International Review of Ophthalmology    2024, 48 (5): 321-326.   DOI: 10.3760/ cma.j.issn.1673-5803.2024.05.001
    Abstract354)      PDF(pc) (871KB)(519)       Save
    Malignant glaucoma is one of the most severe complications of glaucoma surgery. It mainly includes three types: typical malignant glaucoma, malignant glaucoma after cataract surgery, and other secondary malignant glaucoma. Anatomical factors such as a shallow anterior chamber, short axial length, and thick lens, as well as being young, female, diagnosed with angle-closure glaucoma, having a history of external filtration surgery, and preoperative high intraocular pressure, are considered risk factors for the occurrence of malignant glaucoma. The hypothesis of trans-lens pressure differential provides a new perspective for rethinking and understanding the pathogenesis of malignant glaucoma, and may offer new strategies for its prevention and treatment. Relieving ciliary block and restoring the flow of aqueous humor between the anterior and posterior chambers of the eye are key in the treatment of malignant glaucoma.  (Int Rev Ophthalmol, 2024, 48: 321-326)
    Related Articles | Metrics
    Portable visual field testing systems for screening and diagnosis of glaucoma
    Shen Xiaoyuan, Chen Zidong, Yu Minbin
    International Review of Ophthalmology    2024, 48 (4): 241-247.   DOI: 10.3760/cma.j.issn.1673-5803.2024.04.001
    Abstract375)      PDF(pc) (1136KB)(434)       Save
    Visual field testing plays a crucial role in the diagnosis and treatment of glaucoma. Currently, there are various portable visual field testing devices based on personal computers, tablet computers, virtual reality technology, and smartphones that can be used to monitor the visual function of glaucoma patients. For example, the Moorfields Motion Displacement Test (MMDT) based on personal computers and the Melbourne Rapid Fields (MRF) test on tablet computers have initially demonstrated feasibility in community and home settings, while the imo system based on virtual reality technology and the GearVision system based on smartphones have shown practicality. These visual field testing methods are portable, low-cost, relatively accurate, and highly accessible. They provide effective supplementary monitoring tools for glaucoma diagnosis and treatment, and meet the demands of telemedicine. However, there are still issues such as inconsistent screen parameters, resolution limitations, and the need for standardized testing environments that need to be addressed.(Int Rev Ophthalmol, 2024, 48:   241-247)

    Related Articles | Metrics
    Postoperative complications of cataracts associated with high myopia
    Zhang Ye, Qi Jiao, Zhu Xiangjia
    International Review of Ophthalmology    2025, 49 (1): 13-18.   DOI: 10.3760/cma.j.cn115500-20240917-01003
    Abstract220)      PDF(pc) (719KB)(383)       Save
    Highly myopic cataract, as a complex cataract type associated with a high risk of blindness, significantly increases the incidence of postoperative complications, thereby posing a serious threat to the visual health of highly myopic individuals. The common postoperative complications associated with high myopia-related cataracts, include early intraocular pressure elevation, capsular contraction syndrome, posterior capsular opacification, and intraocular lens dislocation. Previous studies have shown that the pathological changes in highly myopic eyes, such as anatomical abnormalities caused by axial elongation, intraocular microinflammatory environments, and oxidative-antioxidative imbalances, contribute to structural and dynamic anomalies in aqueous humor outflow, epithelial-mesenchymal transition of lens epithelial cells, and loosening of the zonular fibers. These factors collectively increase the risk of postoperative complications. Clinically, measures such as meticulous polishing of the capsule during surgery, cautious use of capsular tension rings, and close postoperative monitoring with early intervention can help mitigate these complications to some extent.  (Int Rev Ophthalmol, 2025, 49:  13-18)
    Related Articles | Metrics
    Changes on ocular structures and parameters after ultrasound cycloplasty
    Liu Dongyue, Li Qiang, Zhao Jun
    International Review of Ophthalmology    2024, 48 (5): 327-332.  
    Abstract264)      PDF(pc) (1055KB)(358)       Save
    Ultrasound cycloplasty (UCP) is a new non-invasive glaucoma treatment technology based on high-intensity focused ultrasound. UCP can effectively reduce intraocular pressure (IOP) in the treatment of various types of glaucoma such as primary glaucoma, neovascular glaucoma, traumatic glaucoma and other refractory glaucoma. For increased IOP again after UCP, it is also effective to administer repeated UCP treatment 3~6 months later, when the anterior chamber inflammation is under control. Meanwhile, UCP treatment can cause the changes on ocular structures and parameters, as well as related complications. Most of the complications, changes of ocular structures and parameters such as keratometry, conjunctival and scleral thickness, anterior chamber flare and pupil diameter were transient, usually recovered to preoperative level or subsided within 3~6 months after UCP. The change in anterior chamber depth have not been definitely reported after UCP. However, the scleral ciliary process angle was increased, and the ciliary body area was decreased after UCP. At the same time, further research is needed to clarify the changes and complications in the ocular posterior segment caused by UCP.  (Int Rev Ophthalmol, 2024, 48:  327-332)
    Related Articles | Metrics
    Fixed combination medications for intraocular pressure reduction in glaucoma
    Chen Yihao, Sun Xinghuai
    International Review of Ophthalmology    2025, 49 (2): 88-94.   DOI: 10.3760/cma.j.cn115500-20241108-25202
    Abstract156)      PDF(pc) (878KB)(354)       Save
    The core treatment goal for glaucoma is reducing intraocular pressure. Traditional intraocular pressure -lowering medications are commonly administered as monotherapy or in combination. However, combination therapy often increases treatment complexity, leading to reduced patient adherence and diminished efficacy. Fixed-dose combinations (FDCs) simplify treatment regimens by integrating multiple intraocular pressure-lowering drugs into a single formulation. Studies have shown that FDCs significantly improve adherence compared to non-FDC regimens. Furthermore, the efficacy of FDCs in reducing intraocular pressure is at least non-inferior to non-FDC combinations. Additionally, preservative-free FDCs minimize ocular surface disease caused by preservatives, reducing conjunctival hyperemia rates, significantly improving tolerability. The adoption of FDCs not only optimizes therapeutic outcomes but also alleviates economic burdens, offering a superior treatment option for glaucoma patients. (Int Rev Ophthalmol, 2025, 49:  88-94)
    Related Articles | Metrics
    Application prospects of microRNAs in glaucoma research
    Wu Renyi, Gao Ruxin
    International Review of Ophthalmology    2024, 48 (4): 248-254.   DOI: 10.3760/cma.j.issn.1673-5803.2024.04.002
    Abstract308)      PDF(pc) (733KB)(285)       Save
    miRNAs are small non-coding RNA molecules that participate in the pathophysiological mechanisms of glaucoma. miRNA has the potential to serve as a biomarker for early detection and diagnosis of glaucoma. The study of miRNA in glaucoma helps to elucidate the molecular pathways and mechanisms of glaucoma, promote the development of personalized medicine for glaucoma, and can be applied to the treatment of glaucoma and non-invasive disease monitoring. Although miRNA research in glaucoma has good application prospects, there are also challenges and limitations, such as lack of standardized protocols for sample collection, storage, and DNA extraction, poor tissue specificity and accessibility of samples, and poor reproducibility in different populations. By addressing these limitations, not only can we enhance our understanding of the role of miRNA in glaucoma, but also pave the way for personalized medical methods. (Int Rev Ophthalmol, 2024, 48:  248-254)

    Related Articles | Metrics
    Progress in the application of different diagnostic instruments for preoperative assessment of lens zonule functionality
    Tao Yufei, Pan Xiaohua, Jin Aixia, Fan Ning
    International Review of Ophthalmology    2025, 49 (1): 8-12.   DOI: 10.3760/cma.j.cn115500-20240902-01002
    Abstract195)      PDF(pc) (700KB)(283)       Save
    The lens zonules play a crucial role in maintaining the normal position and shape of the lens. Laxity or rupture of the lens zonules can lead to adverse outcomes such as changes in anterior chamber depth,  increased intraocular pressure,  angle closure,  and partial dislocation of the lens. Abnormalities in lens zonule functionality are prevalent and often concealed in populations with high myopia and angle-closure glaucoma,  presenting significant challenges to cataract surgery. These abnormalities can lead to complications during surgery,  such as difficulty in capsulorhexis,  posterior capsule rupture,  and dropping of the lens into the vitreous cavity. Therefore,  preoperative assessment of lens zonule function is critically important. Currently,  clinical tools such as Ultrasound Biomicroscopy (UBM),  the new generation Swept-source anterior segment optical coherence tomography (SS-AS-OCT),  CASIA2,  and the Pentacam,  which is based on the principle of the Scheimpflug camera and analyzes the anterior segment in three dimensions,  are available for detecting and assessing the function of the lens zonules. UBM can directly detect ruptured lens zonules and assess the location of zonular ruptures but requires patient cooperation for eye movement during the examination. CASIA2,  a non-contact measurement device,  indirectly evaluates lens zonular function by measuring parameters such as anterior chamber depth,  anterior lens surface curvature radius,  lens thickness,  lens tilt,  and decentration,  but it cannot measure the posterior chamber and ciliary body morphology. Similar to CASIA2,  Pentacam assesses lens zonular function but has less comprehensive detection indicators and is prone to measurement errors influenced by factors such as ciliary body morphology. This article compares the advantages and disadvantages of these three instruments in assessing lens zonular function,  guiding clinicians to detect abnormalities in lens zonular function early,  particularly before cataract surgery,  thereby enhancing understanding of ocular pathologies.  (Int Rev Ophthalmol,  2025,  49:  8-12)
    Related Articles | Metrics
    Morphological changes of the Schlemm canal in glaucoma patients
    Zhao Mian, Ye Wenqing, Liang Yuanbo
    International Review of Ophthalmology    2025, 49 (1): 1-7.   DOI: 10.3760/cma.j.cn115500-20241115-01001
    Abstract746)      PDF(pc) (805KB)(277)       Save
    Schlemm canal is a circular tubular structure surrounding the trabecular meshwork around the limbus, which has a different morphological changes ( diameter and area ) in different states and different quadrants. For example, the study showed that the diameter and area of Schlemm canal decreased significantly with age, and the nasal side of Schlemm canal area was greater than the temporal side in normal adults. However, the diameter and area of Schlemm canal in high myopia were significantly larger than that of the normal control group, and the area of Schlemm canal in glaucoma patients was significantly smaller than that of normal subjects. As an important part of the aqueous drainage channel, the measurement of Schlemm canal morphological parameters has been paid great attention by researchers. The measurement methods have been developed from light microscope and electron microscope to ultrasound biological microscopy and optical coherence tomography. Previous studies have reported that the parameters of Schlemm canal in glaucoma patients was significantly smaller than that of normal subjects, as well as glaucoma treatment, such as medication, laser and surgical, can alter the microstructure of the Schlemm canal. (Int Rev Ophthalmol, 2025, 49:  1-7)
    Related Articles | Metrics
    Research progress and clinical application of lens organoids
    Xiong Yingyue, Chen Xiaona, Wei Jia, Gao Yali
    International Review of Ophthalmology    2024, 48 (6): 401-406.   DOI: 10.3760/ cma.j.issn.1673-5803.2024.06.001
    Abstract513)      PDF(pc) (805KB)(205)       Save
    The pathogenesis of cataract is relatively complex, lack of effective drug treatment, and postoperative visual quality cannot be restored to normal state. With the application of stem cell technology in ophthalmology, researchers have used stem cells from various sources to successfully induce the formation of humanoid lenses in vitro and reproduce the microscopic three-dimensional structure of some of their unique functions. These lens organoids are used to build disease models in vitro, study the mechanisms and inductions of related diseases, screen drugs and even regenerate alternative treatments. It provides more possibilities for preventing and treating cataracts. This paper reviews the research progress of lens organoids, introduces the breakthrough research methods, summarizes their clinical applications in mechanism research, drug screening and regenerative replacement therapy, and puts forward personal prospects in the direction of related research and cultivation and the construction of 3D lens or whole eye structure in cooperation with multi-bioengineering. (Int Rev Ophthalmol, 2024, 48:  401-406)
    Related Articles | Metrics
    Anatomical characteristics and mechanisms of primary angle closure glaucoma in myopic eyes
    Liu Yan, Cao Guofan, Zhu Junya, Zhang Linyu
    International Review of Ophthalmology    2025, 49 (2): 81-87.   DOI: 10.3760/cma.j.cn115500-20241019-25201
    Abstract137)      PDF(pc) (2948KB)(173)       Save
    Myopia is generally considered a protective factor for primary angle-closure glaucoma (PACG). However, with the change of environmental factors and the increase of near visual activity, the prevalence of myopia increased significantly, but the incidence of PACG did not decrease accordingly. Myopia, as a protective effect on PACG, actually refers to axial myopia rather than refractive myopia. The non pupillary block mechanism is more common in patients with high myopia and angle closure than in the general angle closure population. The angle closure in PACG patients with long axial length is mainly caused by non pupillary block mechanisms, especially the high pleated iris configuration. The increase in lens thickness and forward movement form a shallow anterior chamber, narrowing the width of the anterior chamber and flattening the corneal edge leading to angle narrower. Changes in iris area, thickness, curvature, as well as ciliary and neurovascular factors also play a certain promoting role in the process of angle closure in axial myopia. (Int Rev Ophthalmol, 2025, 49:  81-87)
    Related Articles | Metrics
    Tear biomarkers for ocular and systemic diseases
    Wang Yue, Xie Xiaodong
    International Review of Ophthalmology    2024, 48 (4): 316-320.   DOI: 10.3760/cma.j.issn.1673-5803.2024.04.013
    Abstract349)            Save
    Tear fluid contains a large number of proteins, cytokines and other substances involved in regulating the function and metabolism of a variety of cells in the eye, thus reflecting the individual pathophysiological state. With the improvement of micro-sample analysis technology, tear fluid has become an ideal source for the detection of potential biomarkers of diseases due to its easy accessibility, convenient storage and stable nature. Glaucoma, keratitis, thyroid-related eye diseases, and even some systemic diseases (Alzheimer's disease, diabetes mellitus, tumors) are associated with changes in potential biomarkers in tear fluid, and their detection may provide some clinical reference value for the prevention and early diagnosis of these diseases.(Int Rev Ophthalmol, 2024, 48:  316-320)

    Related Articles | Metrics
    Research progress  on  anti-VEGF drugs and glucocorticaid drugs for the treatment of retinal vein  occlusion-associated macular edema
    Huang Ju, Li Shiyi, Zhang Ao, Wang Kang, Xie Yingbin
    International Review of Ophthalmology    2024, 48 (4): 267-272.   DOI: 10.3760/cma.j.issn.1673-5803.2024.04.005
    Abstract361)            Save
    Currently, the main therapeutic strategies for retinal vein occlusion-associated macular edema macular edema (RVO-ME) encompass intravitreal injections of anti-vascular endothelial growth factor (VEGF) agents and corticosteroids. The clinical efficacy of dexamethasone intravitreal implant (Ozurdex) for the treatment of RVO-ME in improving visual acuity and reducing central macular thickness (CMT) is superior to that of anti-VEGF drugs at 1 month, and there is no statistically significant difference in clinical efficacy between the two drug types within 3 months post-injection, while Ozurdex needs to be re-injected within 6 months post-injection to maintainits favorable efficacy. When the two types of drugs are combined, either in a spaced or simultaneous injection regimen, they have similar or even better efficacy than monotherapy while reducing the frequency of injections. Meanwhile, intravitreal injections of these two types of drug can cause ocular complications such as high intraocular pressure, concurrent cataracts, endophthalmitis, retinal tears, vitreous hemorrhage, and corneal damage. (Int Rev Ophthalmol, 2024, 48:  267-272)

    Related Articles | Metrics
    The morphological alterations of Bruch's membrane in myopic eyes
    Lu Yuhan, Chen Wei
    International Review of Ophthalmology    2024, 48 (4): 272-277.   DOI: 10.3760/cma.j.issn.1673-5803.2024.04.006
    Abstract290)            Save
    The evolution of myopia is intricately linked to the progressive elongation of the ocular axis. Throughout this process, there is a notable thinning of the choroid and sclera, yet their volumes remain remarkably stable. Intriguingly, the thickness of Bruch's membrane (BM) appears to be decoupled from variations in the axial length of the eye. Given that the spatial separation between the ora serrata and the posterior pole escalates in tandem with axial elongation, this phenomenon suggests a concomitant expansion of the BM surface area. Consequently, the observed independence of BM thickness from changes in axial length provides compelling evidence for a compensatory increase in BM volume as the ocular axis extends. In highly myopia, a robust correlation has been observed between increased axial length and the incidence of BM openings, BM defects, and peripapillary atrophy. These findings indicate that the morphological modifications of BM within myopia may significantly contribute to the pathophysiological mechanisms governing axial elongation, hinting at novel therapeutic targets for myopia management.(Int Rev Ophthalmol, 2024, 48:  272-277)

    Related Articles | Metrics
    The effectiveness and safety of multifocal soft corneal contact lenses in controlling myopia in adolescents
    Wu Ziyan, Yan Zhipeng
    International Review of Ophthalmology    2024, 48 (4): 283-289.   DOI: 10.3760/cma.j.issn.1673-5803.2024.04.008
    Abstract351)            Save
    Multifocal soft contact lenses (MFSCL) is an effective methods of preventing and controlling myopia in adolescents. The concentric ring design and progressive peripheral design of MFSCL have been proven to have good effects for myopia control. Compared to single-vision spectacles and single-vision soft contact lenses, MFSCL has obvious advantages, providing clear long-distance vision, slowing down axial elongation, and delaying myopia progression. However, due to direct attachment to the surface of the eye, it may cause instability of the tear film, conjunctivitis, and chronic damage to various layers of corneal cells caused by hypoxia. Therefore, standardized fitting, nursing, and regular follow-up monitoring are necessary.  (Int Rev Ophthalmol, 2024, 48:  283-289)

    Related Articles | Metrics
    Advances in the diagnosis and treatment of enophthalmos due to burst orbital fracture
    Qi Han, Liu Jinling
    International Review of Ophthalmology    2024, 48 (4): 305-310.   DOI: 10.3760/cma.j.issn.1673-5803.2024.04.011
    Abstract221)            Save
    Orbital fracture is a common type of ocular trauma, and the main clinical manifestations include endophthalmos, binocular diplopia, limited eye rotation, and sensory deficits in the infraorbital innervation area, and so on, with endophthalmos being one of the most common and cosmetically compromising complications. The mechanism causing endophthalmos is mainly related to the imbalance between the volume of orbital contents and orbital bony volume. The traditional surgical technique for orbital fracture repair is usually performed by the clinician after analyzing the CT scanning image data of the orbit according to his experience, which is very subjective and requires the surgeon to make repeated attempts to achieve the best repair results, but it is generally difficult to achieve accurate repair. The choice of implant is also very important to the outcome of the procedure, and the results of resorbable material restorations are widely recognized. At present, three-dimensional printing technology is widely used in the clinic, using three-dimensional printing preform technology to personalize the implant material for fracture patients, and orbital fracture revision surgery can improve the endophthalmos more obviously.(Int Rev Ophthalmol, 2024, 48:  305-310)

    Related Articles | Metrics
    Relationship between depression and dry eye
    Ma Yueni, Yang Ruibo
    International Review of Ophthalmology    2024, 48 (4): 310-315.   DOI: 10.3760/cma.j.issn.1673-5803.2024.04.012
    Abstract251)            Save
    Depression and dry eye are both major social and public health problems that endanger the physiological and psychological health of patients, and they are mutually causative, forming a vicious circle. Inflammation and autonomic dysfunction may be the co-morbid mechanisms of depression and dry eye. Depression-associated dry eye is a chronic pain associated with depression, or dry eye itself is a somatised symptom in depressed patients. Antidepressants can exacerbate or even induce dry eyes. A series of ocular surface irritation symptoms brought about by dry eyes can also cause bad mood in patients. (Int Rev Ophthalmol, 2024, 48:   310-315)

    Related Articles | Metrics
    Impact of strabismus surgery on ocular hemodynamics
    Zhong Huifen, Huang Longxiang, Zheng Weidong
    International Review of Ophthalmology    2024, 48 (4): 298-304.   DOI: 10.3760/cma.j.issn.1673-5803.2024.04.010
    Abstract256)            Save
    Strabismus surgery may trigger hemodynamic changes in the anterior and posterior segments of the eye, further affecting postoperative ocular health and visual function. However, different strabismus surgeries involve different types of muscles, surgical methods, and surgical incisions that have different effects on ocular hemodynamics and duration. Strabismus surgery may cause impaired anterior segment blood flow and increased or decreased retinal and choroid blood flow. The risk of anterior segment ischemia can be reduced by using imaging methods such as iris angiography, color Doppler imaging, and optical coherence tomography angiography (OCTA) to assess the risk factors before strabismus surgery, and selecting an appropriate surgical plan. At the same time, high-precision imaging methods can be used to monitor and evaluate the changes of iris, retina and choroidal blood flow after surgery, which is helpful for the early detection and treatment of ischemia-related complications. (Int Rev Ophthalmol, 2024, 48:  298-304)

    Related Articles | Metrics
    The influence of different haptic designs of intraocular lenses on their axial position
    Zhang Xin, Zhang Yue, Xu Yanhui, Chen Zhimin
    International Review of Ophthalmology    2024, 48 (4): 261-266.   DOI: 10.3760/cma.j.issn.1673-5803.2024.04.004
    Abstract309)            Save
    The position of the intraocular lens(IOL) after cataract surgery is not fixed, and most of it will undergo linear motion after surgery, and then it is relatively stable. The axial position of the IOL is affected by many factors, including the anatomical structure of the eyeball, the surgical method, the design of the IOL, the lens capsular bag, etc. As the supporting element of the IOL, the design of the IOL loop plays a key role in the stability of the axial position of the IOL, including the material of the loop, the thickness and width of the loop, the relationship between the optical part and the loop, the number of loops, the type of loop, the angle of the loop and the diameter of the loop. (Int Rev Ophthalmol, 2024, 48:   261-266)

    Related Articles | Metrics
    Application of anti-scarring therapy in glaucoma filtration surgery
    Liu Yuning, Zhao Chunmei, Liu Xiangyun, Mu Qirui, Zhao Le
    International Review of Ophthalmology    2024, 48 (4): 254-260.   DOI: 10.3760/cma.j.issn.1673-5803.2024.04.003
    Abstract343)            Save
    Scarring around the filtering bleb after glaucoma filtering surgery (GFS) is a major cause of surgical failure. The antimetabolic drug mitomycin-C (MMC) is the first-line treatment for scarring in GFS, but its cytotoxicity can lead to serious complications. Newer anti-scarring approaches include improved surgical techniques (e.g. creation of conjunctival flaps of varying depth), use of physical barriers to the filtration pathway (e.g. biodegradable collagen matrix implants, biodegradable collagen matrix implants, sodium hyaluronate, amniotic membranes, corneal stromal lenses and perfluoropropane gas), and anti-scarring drugs (glucocorticosteroids and non-steroidal anti-inflammatory drugs in addition to MMC, 5-fluorouracil and transforming growth factor-beta-regulating drugs, and the Chinese herbal medicines Dan Huayu Tang, glaucoma and granules, etc.), eye massage, β-radiation therapy, and so on.(Int Rev Ophthalmol, 2024, 48:   254-260)

    Related Articles | Metrics
    The effect of laser corneal refractive surgery on corneal and tear neuromediators
    Shao Yuhao, Li Min, Zou Jun
    International Review of Ophthalmology    2024, 48 (4): 290-297.   DOI: 10.3760/cma.j.issn.1673-5803.2024.04.009
    Abstract281)            Save
    Corneal neuromediators, which are released by corneal nerves and their interactions with target cells, play a crucial role in maintaining normal corneal physiological functions and facilitating the repair process of the cornea. Laser corneal refractive surgery, involving the ablation of the cornea, not only results in corneal tissue damage but also leads to changes in the expression levels of corneal and tear neuromediators postoperatively. Specifically, the expression levels of substance P (SP) and vasoactive intestinal peptide (VIP) in tears are elevated compared to preoperative values, while the changes in the expression levels of calcitonin gene-related peptide (CGRP) in tears and nerve growth factor (NGF) in both the cornea and tears have shown inconsistent results in current research. Additionally, the expression levels of corneal and tear neuromediators are significantly affected by the type of laser corneal refractive surgery and are closely associated with the postoperative recovery of corneal nerve and ocular surface function. (Int Rev Ophthalmol, 2024, 48:  290-297)

    Related Articles | Metrics
    The correlation between helicobacter pylori infection and eye diseases
    Miao Hui, Yang Yiquan, Lv Aiguo, Fan Sujie
    International Review of Ophthalmology    2024, 48 (4): 278-283.   DOI: 10.3760/cma.j.issn.1673-5803.2024.04.007
    Abstract267)            Save
    Helicobacter pylori is a gram-negative bacterium with flagella. In addition to causing gastrointestinal infections, it is also associated with other systemic diseases such as autoimmune diseases, cardiovascular and cerebrovascular diseases, endocrine system diseases, etc. In recent years, increasing studies have found that helicobacter pylori infection also has adverse effects on some eye diseases, such as blepharitis, glaucoma, and central serous chorioretinopathy. Helicobacter pylori can participate in the occurrence and development of the related eye diseases through mechanisms such as stimulating the release of inflammatory mediators, the production of antibodies and effector T cells, and molecular mimicry. Eradicating helicobacter pylori may help treat the aforementioned eye diseases.(Int Rev Ophthalmol, 2024, 48:  278-283)

    Related Articles | Metrics
    Factors affecting microbiological contamination of donor cornea in eye bank
    Ma Yanran, Wang Qin, Yang Lihong, Ren Yi, Zhou Qizhi
    International Review of Ophthalmology    2024, 48 (6): 407-410.   DOI: 10.3760/ cma.j.issn.1673-5803.2024.06.002
    Abstract262)      PDF(pc) (705KB)(129)       Save
    Donor-related infections are a serious threat to patient safety after corneal transplantation. It is important that eye retrieval and eye bank practices are monitored to ensure the provision of high-quality and safe tissue to recipients. Contamination of the donor cornea can occur during its retrieval, storage and processing. This review is focused on the factors including donor, cornea harvest and storage that may affect the microbiological contamination of donor cornea aiming to reduce the contamination rate of donor tissue in eye bank.(Int Rev Ophthalmol, 2024, 48:  407-410)
    Related Articles | Metrics
    Ferroptosis and its role in the pathogenesis of diabetic retinopathy
    Ouyang Qianqian, Zeng Feng
    International Review of Ophthalmology    2025, 49 (3): 197-202.   DOI: 10. 3760/cma.j.cn115500-20241118-25306
    Abstract95)      PDF(pc) (841KB)(110)       Save
    Ferroptosis is a form of iron-dependent, lipid peroxidation-driven cell death. Under conditions of iron overload, glutathione peroxidase becomes inactivated, leading to the accumulation of intracellular lipid peroxides. This triggers severe damage to mitochondria and cell membranes, ultimately resulting in cell death. Diabetic retinopathy (DR) arises from interactions among apoptosis, endothelial hyperplasia, and neuronal apoptosis. Ferroptosis can influence DR pathogenesis through multiple pathways, including iron metabolism dysregulation, abnormal amino acid metabolism, and mitochondrial damage caused by the accumulation of lipid peroxide radicals. Targeted regulation of ferroptosis pathways offers a novel direction for the treatment of DR.

    Related Articles | Metrics
    Relationship between the size of optical zone of orthokeratology lens and myopia control
    Yu Xingmeng, Liu Fang
    International Review of Ophthalmology    2025, 49 (3): 177-181.   DOI: 10. 3760/cma.j.cn115500-20241113-25303
    Abstract47)      PDF(pc) (732KB)(107)       Save
    Orthokeratology (Ortho-K) lenses have been widely used for myopia correction and control in children and adolescents due to their ability to provide clear uncorrected visual acuity and effective myopia suppression. Small optical zone Ortho-K lenses refer to designs with an optical zone diameter smaller than 6.0 mm, typically featuring specifications such as 5.0 mm or 5.5 mm optical zones. Compared to conventional Ortho-K lenses with larger optical zones, small optical zone lenses induce a smaller central treatment zone and a steeper mid-peripheral defocus ring. This design generates more pronounced peripheral retinal myopic defocus and higher-order aberrations, thereby enhancing myopia control efficacy. However, such optical characteristics may lead to reduced objective visual quality parameters, such as the modulation transfer function (MTF).

    Related Articles | Metrics
    Research progress of corneal collagen crosslinking in the treatment of keratoconus 
    Wang Xiaoxuan, Sun Fangfang , Liu Xiaopeng, Luo Junxiang, Lei Yulin
    International Review of Ophthalmology    2025, 49 (3): 189-197.   DOI: 10. 3760/cma.j.cn115500-20241115-25305
    Abstract60)      PDF(pc) (831KB)(105)       Save
    Keratoconus(KC) is a common congenital, progressive, non-inflammatory degenerative corneal disorder. Corneal collagen cross-linking can increase corneal stiffness and control disease progression. Enhanced riboflavin penetration is achieved through iontophoresis and penetration enhancers; improved oxygen supply for better cross-linking efficacy is facilitated by pulsed light, oxygen delivery devices, and graphitic carbon nitride quantum dot-based oxygen self-supply platforms; riboflavin formulations using hydroxypropyl methylcellulose as a carrier prevent intraoperative corneal thinning; Rose Bengal-green light illumination combined with chemical cross-linking agents reduces biotoxicity; customized ultraviolet collagen cross-linking targeting specific weakened corneal areas maintains keratoconus stability; and epithelial-sparing riboflavin cross-linking protocols overcome the corneal epithelium barrier against large/hydrophilic drug molecules while avoiding complications associated with epithelial debridement.

    Related Articles | Metrics
    Factors influencing corneal biomechanics
    Gong Yuwei, Qin Yu, Zheng Yajie, Yang Haoming, Li Lei, Xiao Ruohan, Liang Gang
    International Review of Ophthalmology    2025, 49 (3): 170-176.   DOI: 10. 3760/cma.j.cn115500-20241216-25302
    Abstract84)      PDF(pc) (815KB)(94)       Save
    Corneal biomechanics are fundamental properties that determine the morphological stability and optical function of the cornea. Factors affecting corneal biomechanics include physiological factors (e.g., age, intraocular pressure, refractive status, hormonal levels), behavioral factors (e.g., contact lens wear, use of eye drops, eye rubbing, smoking), ocular and systemic diseases (e.g., keratoconus, glaucoma, diabetes mellitus, dry eye disease, keratoconjunctivitis, thyroid-associated ophthalmopathy), as well as surgical interventions and trauma. These factors collectively regulate corneal properties such as stiffness, deformability, and energy dissipation.

    Related Articles | Metrics
    Recent progress in diagnosis, treatment and research of geographic atrophy
    Liao Xingming, Yang Yuting, Ma Hongjie
    International Review of Ophthalmology    2024, 48 (5): 333-340.   DOI: 10.3760/ cma.j.issn.1673-5803.2024.05.003
    Abstract379)            Save
    Geographic atrophy (GA) is an advanced form of age-related macular degeneration, characterized by progressive and irreversible loss of photoreceptors, retinal pigment epithelium, and choriocapillaris. Ophthalmic imaging technologies, such as color fundus photography, fundus autofluorescence, and optical coherence tomography, are crucial tools for diagnosing and assessing disease progression in GA. Monitoring visual function is essential in the disease surveillance of GA, and a single visual function test may not fully reflect the patient's true visual experience. A comprehensive assessment should combine best corrected visual acuity, low luminance visual acuity, and microperimetry to provide a more complete evaluation. Currently, there is no effective treatment for GA, but emerging therapies such as complement inhibitors and gene therapy show promising prospects. (Int Rev Ophthalmol, 2024, 48:  333-340)
    Related Articles | Metrics
    International Review of Ophthalmology    2024, 48 (5): 340-340.   DOI: 10.3760/ cma.j.issn.1673-5803.2024.05.012
    Abstract190)            Save
    Related Articles | Metrics
    The roles of stromal cell-derived factor-1/C-X-C chemokine receptor type 4/C-X-C chemokine receptor type 7 signaling in choroidal neovascularization progression
    Zou Rong, Yuan Fei
    International Review of Ophthalmology    2024, 48 (5): 341-348.   DOI: 10.3760/ cma.j.issn.1673-5803.2024.05.004
    Abstract243)            Save
    Choroidal neovascularization (CNV) is an important pathological mechanism of blinding neovascular age-related macular degeneration (NVAMD). Vascular endothelial growth factor (VEGFA), the key regulator of angiogenesis, not only mediates the localization and structural remodeling of the capillary plexus during normal eye development by binding to its tyrosine kinase receptor, but also promotes pathological angiogenesis and leakage. Recent studies has proved that stromal cell-derived factor-1 (SDF-1) mediates the chemotaxis of immune cells such as endothelial progenitor cells and macrophages by binding to its C-X-C chemokine receptor type (CXCR) 4 and CXCR7. It also directly activates signaling pathways such as PI3K/AKT/ERK in endothelial cells to promote endothelial cell proliferation, migration, and angiogenesis, thereby regulating the development of pathological choroidal neovascularization and induces endothelial-to-mesenchymal transition of endothelial cells (EndoMT) to promote subretinal fibrosis. (Int Rev Ophthalmol, 2024, 48:  341-348)
    Related Articles | Metrics
    Affecting factors of refractive error after cataract surgery in patients with aqueous eye status
    Su Wenhua , , Wang Xuelin , Lu Xiaohe , Chen Juanjuan , Huang Xinyu , Li Yingli
    International Review of Ophthalmology    2024, 48 (6): 420-425.   DOI: 10.3760/ cma.j.issn.1673-5803.2024.06.005
    Abstract271)            Save
    With the prevalence of myopia, there is a trend towards an increase in the number of people requiring vitrectomy to preserve the lens. The risk of cataract after vitrectomy (aqueous eye status) is about 22.5%~60%, and refractive drift after cataract of aqueous eye status surgery has received more attention. Although cataract surgery technology continues to advance and examination equipment is constantly updated, some preoperative, intraoperative, and postoperative factors cause postoperative refractive error to be more obvious than that of normal eye cataract. In addition to paying attention to the patient's ocular surface health, the accuracy and repeatability of optical biometry, and the selection of the appropriate IOL refractive power calculation formula, the change of the axial length and the actual position of the IOL should also be paid attention to. Choosing the appropriate IOL calculation formula can reduce the refractive error after surgery. The SRK/T formula, Kane formula, Haigis formula, and Barrett Universal II formula are used to calculate the refractive error of high myopia, but whether they can be used in patients with cataract of aqueous eye status is worth exploring.  (Int Rev Ophthalmol, 2024, 48:  420-425)
    Related Articles | Metrics
    Oculomechanics medicine
    He Yuan, Du Huan, Ge Ping, Jia Yuanbo, Xu Feng, Sun Xinghuai
    International Review of Ophthalmology    2025, 49 (3): 161-170.   DOI: 10. 3760/cma.j.cn115500-20250331-25301
    Abstract118)      PDF(pc) (1164KB)(82)       Save
    With the development of interdisciplinary integration between medicine and engineering, the role of mechanical factors in the pathogenesis, progression, diagnosis, and treatment of ophthalmic diseases has become increasingly prominent, emerging as a focal point in both basic and clinical research.Oculomechanics medicine focuses on the application of mechanical factors in understanding disease mechanisms and developing therapeutic interventions in ophthalmology. Centered on establishing direct correlations between biomechanical parameters of ocular tissues and clinical management, this field organically integrates four key components: ocular biomechanics, ocular mechanobiology, ocular mechanodiagnostics, and ocular mechanotherapeutics. Specifically, ocular biomechanics investigates the mechanical responses arising from biological changes in ocular tissues, while ocular mechanobiology explores biological alterations induced by mechanical forces. Ocular mechanodiagnostics leverages mechanical characteristics to develop novel diagnostic tools for enhanced precision in early disease detection, whereas ocular mechanotherapeutics focuses on formulating personalized treatment strategies through mechanical interventions in ocular tissues.

    Related Articles | Metrics
    Application of multi-omics technology in the pathogenesis, diagnosis and treatment of IgG4-related ophthalmic disease
    Liu Rui, Ma Jianmin
    International Review of Ophthalmology    2025, 49 (3): 229-234.   DOI: 10. 3760/cma.j.cn115500-20241202-25312
    Abstract70)      PDF(pc) (1223KB)(79)       Save
    IgG4-related ophthalmic disease (IgG4-ROD), a manifestation of IgG4-related disease in ocular tissues, has emerged as a key focus in the study of inflammatory orbital lesions in recent years. IgG4-ROD primarily affects the lacrimal glands and may involve multiple sites such as extraocular muscles, orbital fat, and conjunctiva. It often co-occurs with other systemic conditions, yet its complex pathogenesis remains incompletely understood, particularly regarding fibrosis and potential mechanisms of malignant transformation, which require further investigation. Current advances in multi-omics technologies—including genomics, transcriptomics, metabolomics, and radiomics—have provided critical insights into the disease mechanisms, diagnostic differentiation, and therapeutic strategies for IgG4-ROD. The integration of multi-omics approaches offers novel research perspectives and technical pathways to achieve precision diagnosis and treatment.

    Related Articles | Metrics
    Application of intraoperative optical coherence tomography in corneal transplantation surgery
    Zhan Xin, Liu Hongshan
    International Review of Ophthalmology    2024, 48 (5): 357-363.   DOI: 10.3760/ cma.j.issn.1673-5803.2024.05.006
    Abstract226)            Save
    Intraoperative optical coherence tomography (iOCT) is an intraoperative navigation microscope system that can be used not only for surgeries such as vitreoretinal, ICL implantation, cataracts, glaucoma, but also for corneal transplantation surgery. In penetrating keratoplasty, the real-time visualization of iOCT helps the surgeon understand the intraocular situation, define the implant bed range, and handle angle adhesions. In lamellar keratoplasty, the depth and uniformity of corneal stroma detachment can be observed to prevent perforation of the posterior elastic layer, timely treatment of interlayer fluid accumulation, and avoid the formation of double anterior chambers. In addition, in corneal endothelial transplantation, iOCT can reveal the position of the graft and its adhesion to the corneal stroma, observe whether the graft is unfolded or inverted, and help the surgeon handle it in a timely manner to improve the success rate of the surgery. (Int Rev Ophthalmol, 2024, 48:  357-363)
    Related Articles | Metrics
    Mechanism of low-intensity red light therapy in regulating axial elongation
    Wang Yumo, Sun Hongyan, Lin Hongzhan, Yang Mingming
    International Review of Ophthalmology    2024, 48 (6): 426-432.  
    Abstract650)            Save
    Myopia has become an urgent problem in global public health. Low-intensity red light therapy has been shown to be effective in delaying axial elongation in a non-invasive manner, but its mechanism remains unclear. Low-intensity red light therapy is based on the principle that specific molecules absorb photons and respond to light signals, resulting in changes in the electronic excited state of molecules, temporarily changing their structure and function, and achieving highly specific and targeted biological regulation. The regulation of axial length involves a complex cascade of reactions that begins in the retina and affects the sclera. Light exposure is closely related to axial elongation. Previous studies have indicated that the visual stimulation elicited by low-intensity red light is received by retinal neurons and generates signals, which are transduced through the retinal pigment epithelium and choroid to the sclera, leading to the release of neurotransmitters, alterations in choroidal blood flow, and scleral remodeling. This review explores the relationship between low-intensity red light therapy and axial regulation, investigating the mechanisms by which low-intensity red light slows down axial growth. (Int Rev Ophthalmol, 2024, 48:  426-432)
    Related Articles | Metrics
    Evaluation of quality of life questionnaire for low vision patients
    Zhao Weiqi, Liu Bo, Hong Yuchen, Yang Xiaohui
    International Review of Ophthalmology    2025, 49 (3): 235-240.   DOI: 10. 3760/cma.j.cn115500-20250516-25313
    Abstract93)      PDF(pc) (749KB)(76)       Save
    Low vision severely impacts patients' visual quality and overall quality of life (QoL).QoL questionnaires are widely used to evaluate the effects of visual impairment on daily living. These questionnaires are categorized into vision-related quality of life (VRQoL) scales and health-related quality of life (HRQoL) scales. Common general-purpose scales include the National Eye Institute Visual Function Questionnaire (NEI-VFQ), Low Vision Quality of Life Questionnaire (LVQoL), Visual Function Index (VF-14),Short Form Health Survey Questionnaire(SF-36), and EuroQol 5-Dimension Questionnaire (EQ-5D). Specialized scales such as the Children’s Visual Function Questionnaire (CVFQ) are also available for pediatric and adolescent populations. In clinical practice, combining VRQoL and HRQoL assessments provides a more comprehensive evaluation of low-vision patients’ QoL and the effectiveness of rehabilitation interventions.

    Related Articles | Metrics
    The relationship between Wnt/β-catenin signaling pathway and the pathogenesis of myopia
    Adilai·Aikebaier, Ding Lin
    International Review of Ophthalmology    2024, 48 (6): 433-437.   DOI: 10.3760/ cma.j.issn.1673-5803.2024.06.007
    Abstract263)            Save
    The etiology of myopia involves a complex regulatory process of the retina-choroid-sclera axis, wherein the Wnt/β-catenin pathway plays a pivotal role as a significant signaling pathway in myopia development. Studies indicate that activation of the Wnt/β-catenin pathway correlates positively with the severity of myopia, and inhibiting this pathway may potentially slow the progression of myopia. Moreover, individuals with myopia exhibit significantly reduced levels of DKK-1 (Dickkopf-1) in their blood, and supplementation of DKK-1 may mitigate axial elongation of the eye and progression of myopia. These findings pave the way for novel research directions in therapeutic strategies based on the Wnt/β-catenin pathway.(Int Rev Ophthalmol, 2024, 48:  433-437)
    Related Articles | Metrics
    Research progress of anterior chamber-associated deviation
    Li Qian, Qing Guoping
    International Review of Ophthalmology    2024, 48 (5): 364-370.   DOI: 10.3760/ cma.j.issn.1673-5803.2024.05.007
    Abstract272)            Save
    Anterior chamber-associated immune deviation (ACAID) is the primary manifestation of ocular immune privilege. It mainly involves the roles of antigen-presenting cells and regulatory T cells to inhibit systemic immune responses against intraocular antigens. The underlying mechanisms are complex, relying not only on the normal anatomical structure and physiological functions of the eye but also involving dynamic immune regulatory processes and humoral balance. Recent research has revealed more molecular mechanisms related to ACAID, such as the roles of immune checkpoint molecules and their impact on immune tolerance. Moreover, studies of ACAID mechanisms have demonstrated its potential applications in preventing graft rejection and treating autoimmune eye diseases. These research findings provide new perspectives on understanding the process of ocular immune privilege and are of significant importance in developing novel anti-inflammatory and immunotherapeutic approaches.  (Int Rev Ophthalmol, 2024, 48: 364-370)
    Related Articles | Metrics
    The value of axial length measurement in  myopia prevention and control   among children and adolescents
    Li Ruofan, Xian Haocheng, Li Xuemin, Zhang Chun, Pan Zhe
    International Review of Ophthalmology    2025, 49 (1): 56-61.   DOI: 10.3760/cma.j.cn115500-20241009-01010
    Abstract199)            Save
    Axial length (AL) is a crucial parameter for assessing eye development in children and adolescents,  as its growth is closely associated with the progression of myopia. In this age group,  AL exhibits a consistent growth trend with age,  making dynamic monitoring of its changes particularly significant. However,  several factors—including genetics,  baseline refractive status,  pathological myopia,  and anthropometric measurements—can influence AL changes. The presence of individual variability adds complexity to predicting refractive properties based on ocular axis length alone. Despite these challenges,  AL remains a vital indicator for forecasting the onset and progression of myopia. Research indicates that when AL is considered alongside other parameters such as corneal curvature radius,  corneal refractive power,  and uncorrected distant visual acuity,  it holds significant clinical value for myopia diagnosis. Interventions such as orthokeratology lenses,  low-concentration atropine,  low-energy red light therapy,  and increased outdoor activity have all been associated with delayed axial growth. It is essential to consider the specific circumstances of each individual patient when applying these treatments. Currently,  AL measurement primarily depends on optical biometry; however,  attention must be given to patient cooperation and the selection of appropriate equipment.  (Int Rev Ophthalmol, 2025, 49:  56-61)
    Related Articles | Metrics
    The development history of photorefraction technology and its application in screening for refractive errors in children
    Huang Yan, Gao Jie, Zhen Yi
    International Review of Ophthalmology    2024, 48 (5): 385-392.   DOI: 10.3760/ cma.j.issn.1673-5803.2024.05.010
    Abstract242)            Save
    Photorefraction technology determines the refractive status of children by analyzing images of light reflected from the retina. This method is suitable for younger children who have difficulty cooperating for extended periods, significantly enhancing the feasibility of early screening for myopia, hyperopia, astigmatism, and strabismus, making large-scale screenings possible. Photorefraction technology has evolved from film imaging to digitalization, miniaturization, and intelligence. In particular, the integration of artificial intelligence technology has significantly improved diagnostic accuracy and adaptability. Deep learning algorithms automatically analyze and extract features from eye images, enabling photorefractors to maintain high stability and accuracy in complex environments. The application of digital simulation technology also provides a scientific basis for further optimization of photorefraction technology, simulating imaging effects under different ocular conditions and providing strong support for improving device performance. With the commercialization of technology, various models of photorefractors have been developed, such as MTI, iScreen, PowerRefractor, Plusoptix, Spot, GoCheckKids, etc. These devices continue to improve in portability, ease of operation, and diagnostic accuracy, providing diverse options for screening refractive errors in children. Photorefraction technology is increasingly widely used in screening for refractive errors in children, with notable progress. Diagnostic accuracy and efficiency have been significantly improved, providing important technical support for early intervention and protection of global children's visual health. (Int Rev Ophthalmol, 2024, 48:  385-392)
    Related Articles | Metrics
    Relationship between ocular biological parameters and corneal higher-order aberrations in cataract patients#br#
    Yong Zixuan, Huang Xionggao
    International Review of Ophthalmology    2024, 48 (6): 416-419.   DOI: 10.3760/ cma.j.issn.1673-5803.2024.06.004
    Abstract300)            Save
    The visual outcomes of cataract surgery are significantly influenced by preoperative ocular biometric parameters and corneal higher-order aberrations. As cataract surgery transitions from vision-restoring procedures to refractive surgeries, the demand for better postoperative visual quality has become increasingly stringent. This review explores the relationship between ocular biometric parameters (such as central corneal thickness, corneal refractive power, anterior chamber depth, anterior chamber angle, lens thickness, pupil size, and axial length) and corneal higher-order aberrations. The central corneal thickness is negatively correlated with total higher-order aberrations, spherical aberration, and coma, but positively correlated with trefoil aberration. Corneal refractive power affects higher-order aberrations, with myopic patients showing lower total higher-order aberrations, while hyperopic patients show higher values. The influence of anterior chamber depth on higher-order aberrations is controversial, with some studies indicating that a shallow anterior chamber increases corneal spherical aberration. An increase in pupil size is associated with an increase in higher-order aberrations. Additionally, axial length is negatively correlated with total corneal higher-order aberrations and spherical aberration. Accurate measurement of these parameters aids in predicting postoperative visual outcomes and optimizing individualized treatment for cataract surgery.(Int Rev Ophthalmol, 2024, 48:  416-419)
    Related Articles | Metrics