Table of Content

25 January 2017, Volume 26 Issue 1

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From the prevention and treatment of blindness to the universal eye health

YANG Xiao-hui, HU Ai-lian, WANG Ning-li.

2017, 26(1):  1-3.  doi:10.13281/j.cnki.issn.1004-4469.2017.01.001

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During the "Twelfth Five-Year Plan" period, the Chinese government had vigorously advanced the work in prevention and treatment of blindness, effectively curbed the main blinding eye diseases, decreased the prevalence of blindness by 25%. However, as people's lifestyle changes along with the rapid economic and social development in China, there has been an increase in age-related eye diseases and changes in spectrum of eye diseases. Therefore, the priorities of blindness prevention have shifted from the blindness prevention and the treatment of the blind to the eye health management and the prevention of eye diseases. The "National Plan for the Prevention of Blindness" has changed into the "13th Five-Year National Eye Health Plane". During the "Thirteenth Five-Year Plan" period, eye health, as an important part of "Healthy China" Plan, has become a significant component of "Healthy China" Plan. We should give special attention on prevention and treatment of blindness and visual impairment to further enhance level of people's eye health by 2020. (Ophthalmol CHN, 2017, 26: 1-3)

Therapeutic plasma exchange for acute optic neuritis 

ZHUANG Yuan1, XU Quan-gang2, WEI Shi-hui2.

2017, 26(1):  6-9.  doi:10.13281/j.cnki.issn.1004-4469.2017.01.004

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Therapeutic plasma exchange (TPE) can remove the pathogenic components effectively such as autoimmune antibodies and proinflammatory cytokines in serum. It may also modify the immune function of patients. If patients with acute optic neuritis (ON) do not respond to intravenous methylprednisolone (IVMP) therapy or they are intolerant to IVMP, TPE may be beneficial in the acute setting. However, adverse events such as allergy and electrolyte disturbances should be alerted. The exact effect of TPE for acute ON and its optimal treatment strategy need to be further investigated. (Ophthalmol CHN, 2017, 26: 6-9)

Diagnostic capability of ganglion cell complex for preperimetric glaucoma with spectral-domain optical coherence tomography

WANG Wei-wei1, WANG Huai-zhou2, LIU Jian-rong1, HUO Yan-jiao2, LI Meng2, YANG Xin-guang1.

2017, 26(1):  10-14.  doi:10.13281/j.cnki.issn.1004-4469.2017.01.005

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Objective To evaluate the diagnostic capabilities of ganglion cell complex (GCC) thickness in preperimetric glaucoma (PPG) with spectral domain optical coherence tomography (SD-OCT). Design Self control study and case control study. Participants Primary open-angle glaucoma (POAG) patients were 20 cases(40 eyes), of which 20 eyes without visual field defects as PPG, and healthy controls were 30 cases(30 eyes). Methods All subjects were underwent macular scanning and peripapillary retinal nerve fiber layer (RNFL) scanning using the RTvue SD-OCT. The area under the receiver operating characteristic curve (AUC) was used to assess the ability to discriminate PPG from normal control. Main Outcome Measures The thickness of GCC and RNFL, and their AUCs. Results Compared with normal eyes, the thickness of average GCC, superior GCC, inferior GCC, average RNFL, superior RNFL, and inferior RNFL in PPG eyes decreased (P<0.001). However, these parameters were thicker than POAG eyes (P≤0.002). The values of GCC-GLV and GCC-FLV increased compared with normal eyes (P<0.001, P=0.021)， but decreased compared with POAG eyes (P<0.001). GCC-GLV had highest AUC for detecting PPG (0.983) from normal eyes, followed by average RNFL (0.930). However, the difference between the two parameters was not statistically significant (P>0.05). Conclusions In addition to RNFL, the GCC could be a structural parameter for detecting PPG. (Ophthalmol CHN, 2017, 26: 10-14)

The indications of initial treatment for angle-closure glaucoma

ZHANG Ming1, FAN Su-jie2, LIANG Yuan-bo3, HAN Wei2, WANG Ning-li4.

2017, 26(1):  15-20.  doi:10.13281/j.cnki.issn.1004-4469.2017.01.006

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Objective To compare the Chinese conventional practice patterns of primary angle-closure glaucoma (PACG) with American Academy of Ophthalmology recommended practice patterns in a setting of tertiary eye hospital in China.  Design Retrospective case series. Participants 148 eyes with acute angle closure glaucoma (AACG) and 245 eyes with chronic angle closure glaucoma (CACG) between October 2005 and March 2007 at Handan Eye Hospital. Methods All eyes were undergone laser peripheral iridotomy (LPI), with a follow up time of 1-18 months. Based the database, we assumed to treat the patients with Chinese conventional practice patterns, to see the proportions of overtreatment and the potential undertreatment. Main Outcome Measures The ratio of overtreatment and undertreatment. Results In accordance with conventional practice patterns for PACG in China, 45 AACG eyes and 89 CACG eyes will take trabeculectomy, among which 46.7% (21/45) of AACG eyes and 49.4% (44/89) of CACG eyes can be well controlled by LPI, respectively. With laser preferred strategy, the rate of inadequate treatment will be increased from 10.8%（16/148）to 29.7% (44/148) in AACG eyes and from 18.4% (45/245) to 42.4% (104/245) in CACG eyes. Conclusion Filtery surgery in PACG is seriously overdone in China with conventional practice patterns. The rate of inadequate treatment will be increased remarkablely with laser preferred practice pattern, about 2-3 times compared with the traditional mode of filtration surgery. Therefore, taking both the degree of PAS and optic nerve damage into the consideration of choosing filtration surgery or not for PACG patients, may be utmost to avoid excessive treatment and reduce the inadequate treatment. (Ophthalmol CHN, 2017, 26: 15-20)

Study of the circadian fluctuation of ocular perfusion pressure in different position in primary open-angle glaucoma patients 

HU Hui-li, LI Jin-ying, RU Jia-li, LIAO Su-hua.

2017, 26(1):  20-25.  doi:10.13281/j.cnki.issn.1004-4469.2017.01.007

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Objective To characterize the circadian fluctuation of ocular perfusion pressure (OPP) in different position  in patients with newly diagnosed, untreatedprimary open-angle glaucoma（POAG）. Design Cohort study. Participants Nineteen patients with POAG (19 eyes) and eighteen healthy controls (18 eyes) were included in the Peking University Shenzhen Hospital. Methods POAG patients and healthy controls were included and underwent 24-hour monitoring of IOP and blood pressure. On 10:00, 14:00, 18:00 and 22:00 o’clock in the daytime, all the subjects were monitored in sitting position, then POAG patients were monitored again after lying down for 5 minutes. On 2:00, 5:00 and 7:00 o’clock at night all the subjects were monitored in supine position, then POAG patients were monitored again after sitting for 5 minutes. Calculating the mean ocular perfusion pressure (MOPP), the systolic ocular perfusion pressure (SOPP) and diastolic perfusion pressure (DOPP) by the formula and analyzing the data. Main Outcome Measures  MOPP, SOPP, DOPP. Results In both groups of habitual position (sitting position in day and supine position in night), the nocturnal MOPP, SOPP and DOPP were lower than diurnal. In both groups, the nocturnal MOPP was lower than diurnal in habitual position (POAG group t=4.092, P=0.000; healthy group t=4.513, P=0.000). However, there was no obvious difference between those two groups (t=-0.973, P=0.350). POAG group had higher 24-hour fluctuation of MOPP (t=2.204, P=0.039), higher nocturnal fluctuation of SOPP (t=3.097, P=0.018), higher nocturnal and 24-hour fluctuation of DOPP than healthy group, all the differences had statistical significance (all P<0.05).  In POAG group , there was no statistical difference between the nocturnal MOPP and the diurnal MOPP in sitting position or in supine position of 24 h (all P>0.05). POAG group had higher 24-hour mean MOPP in sitting position than in supine position, the difference had statistical significance (t=4.306, P=0.001).  Comparing the MOPP of  POAG group  in habitual position with in sitting position of 24 h, there was no statistical difference(t=-2.101, P=0.080). However, POAG group had higher 24-hour mean MOPP in habitual position than in supine position of 24 h, the difference had statistical significance (t=2.707, P=0.035). Conclusions There circadian fluctuation of  OPP in different position in POAG pations can not be treated as the same. The nocturnal MOPP  was lower than diurnal in habitual position, but there was no obvious difference in the 24h-sitting position and 24h-supine position.  (Ophthalmol CHN, 2017, 26: 20-25）

Water drinking test influences intraocular pressure, axial length and choroid thickness in normal young adults

ZHANG Hui,HONG Jie, HUO Yan-jiao, WANG Huai-zhou, WANG Ning-li.

2017, 26(1):  26-29.  doi:10.13281/j.cnki.issn.1004-4469.2017.01.008

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Objective To explore intraocular pressure (IOP), axis length and choroid thickness changes in healthy people after water drinking test. Design Cohort study. Participants Twenty eight young healthy volunteers with a mean age of 27.75 years. Methods Volunteers underwent water drinking test with drinking water 20 ml/kg in 5 minutes after 2 hours fasting. Measurements of choroidal thickness, IOP, and ocular biometry were taken before and after water drinking 10 min, 15 min, 30 min, 60 min. Enhanced Depth Imaging optical coherence tomography (EDI-OCT) was used to measure choroidal thickness at the fovea. IOP was measured by Goldmann applanation tonometry. Ocular biometric measures were collected using A scan ultrasound. The data of one eye of each volunteer were analyzed. Main Outcome Measures IOP, chroid thickness, axial length, anterior chamber depth, vitreous thickness, lens thickness. Results After water drinking 10 min, 15 min, 30 min, 60 min, the IOP was 14.51±2.60, 17.59±2.44, 17.19±2.78, 15.46±2.45 mmHg, respectively (P<0.001). After water drinking 30 min anterior chamber depth shallowed (P=0.04), after water drinking 60 min axial length shortened (P=0.02) and vitreous length thickness shortened (P=0.04). There was statistically significant difference. However, there was no significant difference in the mean choroidal thickness (P=0.935). Before water dringking and after water drinking 10 min, 15 min, 30 min, 60 min, the choroid thickness was 330.79±84.81, 340.00±91.97, 336.57±92.93, 334.86±85.63, 338.43±96.86 μm, respectively (P=0.935). Conclusion There is a significant increase in IOP from water drinking test. The axial length become shorter, the anterior chamber depth become shallow and the vitreous thickness become shorter, and the lens thickness and the choroid thickness have no significant changes. (Ophthalmol CHN, 2017, 26: 26-29）

The observation of the eyeball structure and intraocular pressure changes after two types of external-route microsurgery for rhegmatogenous retinal detachment 

ZHAO Yang, YUAN Hui-ping.

2017, 26(1):  30-34.  doi:10.13281/j.cnki.issn.1004-4469.2017.01.009

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Objective To evaluate the eyeball structure changes and the influence of intraocular pressure (IOP) after two types of external-route microsurgery (the local buckling and the local buckling received encircling) in patients with rhegmatogenous retinal detachment(RD). Design Retrospective case series. Participants 64 patients (64 eyes) with rhegmatogenous RD were treated with the local buckling (25 eyes) or the local buckling and encircling (39 eyes). Methods Biological data were measured with A-scan and ultrasound biomicroscopy (UBM) and IOP were measured with non-contact tonometry at preoperation, and postoperative1 week, 1 month and 3 months. Main Outcome Measures Intraocular pressure, corneal thickness, corneal curvature, central anterior chamber depth, thickness of lens, ciliary thickness and trabecular-iris angle. Results After 3 months of external-route microsurgery, the retina was anatomically reattached in all 64 patients. Compared with preoperative data, IOP, corneal thickness, corneal horizontal curvature, corneal vertical curvature, thickness of lens and ciliary thickness were significantly increased at 1 week after surgery (all P<0.05). The difference of IOP was no statistically significant at 1 month and 3 months after the operation in the local buckling group. On the contrary, it has significantly meaningful changes at 3 months (15.41±2.58 mmHg) to compared with that (13.66±3.16 mmHg) before surgery in the local buckling group (P=0.009). At 1 week after surgery, the corneal vertical curvatures of these two groups were (45.03±1.08) D and (44.47±0.90) D (P=0.027). Conclusions The local buckling and the local buckling combined encircling for rhegmatogenous retinal detachment can early influence eyeball structure significantly, including cornea, anterior chamber and anterior chamber angle. Intraocular pressure is affected for longer duration and should be given attention and intervention. (Ophthalmol CHN, 2017, 26: 30-34)

Influence of IL-17A-OVA vaccine to experimental autoimmune uveoretinitis

WANG Yin-lin1, ZHOU Ya-qi2, WANG Hong1, ZHAO Meng1, WEI Wen-bin1.

2017, 26(1):  34-38.  doi:10.13281/j.cnki.issn.1004-4469.2017.01.010

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Objective To investigate the influence of IL-17A-OVA vaccine to experimental autoimmune uveoretinitis (EAU). Design Experimental study. Participants Thirty C57BL6 mouses. Methods To produce  IL-17A-OVA vaccine. Thirty C57BL6 mouses were equally divided into adjuvant group, vaccine group and Cyclosporine (CsA) group at random. The first two groups were immunized by IL-17A-OVA or adjuvant firstly. Then EAU with interphotoreceptor retinoid-binding protein (IRBP) in the tenth week was induced. The latter group induced EAU firstly and then given CsA by intragastric administration for 2 weeks. Eyeball biopsy of mouse was observed with HE staining two weeks after EAU induction. IL-17A, IL-17A IgG, IL-6, IL-23 in the serum was measured with ELISA. Main Outcome Measures IL-17A, IL-17A IgG, IL-6 and IL-23 levels in mouse serum. Results HE staining shows that there were significant difference in histopathological score not only between adjuvant group and vaccine group, but also between adjuvant group and CsA group, there was no significant difference between vaccine group and CsA group. IL-17A of vaccine group and Cyclosporine group were significantly lower than adjuvant group (adjuvant group, 33.774±6.478 pg/ml; vaccine group , 25.785±4.677 pg/ml; CsA group, 23.129±3.940 pg/ml ; F=8.125, P=0.003). IL-17A IgG of vaccine group was higher than adjuvant group and CsA group, there was no significant difference between CsA group and adjuvant group(adjuvant group, 56.712±4.214 pg/ml; vaccine group, 106.379±12.603 pg/ml; CsA group, 59.431±8.626 pg/ml ; F=63.008, P=0.000). IL-6 of vaccine group and CsA group were significantly lower than adjuvant group (adjuvant group, 49.329±8.768 pg/ml ; vaccine group, 41.124±4.959 pg/ml; CsA group, 29.418±3.347 pg/ml; F=18.603, P=0.000). IL-23 of CsA group was significantly lower than vaccine group and adjuvant group, there was no significant difference between vaccine group and adjuvant group (adjuvant group, 109.770±20.848 pg/ml; vaccine group, 100.893±13.467 pg/ml; CsA group, 73.492±12.324 pg/ml; F=4.916, P=0.018). Conclusions IL-17A-OVA vaccine has infulunce in reducing the expression of EAU inflammation by the means of IL-17A IgG passway, and may be a new treatment to autoimmune uveitis. (Ophthalmol CHN, 2017, 26: 34-38)

Refractive changes after pharmacologic resolution of macular edema induced by retinal vein occlusion 

WU Xi-shi,ZHENG Bin,LIN Li,SHEN Li-jun.

2017, 26(1):  39-43.  doi:10.13281/j.cnki.issn.1004-4469.2017.01.011

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Objective To determine the change of refractive power caused by treatment in patients with macular edema induced by retinal vein occlusion. Design Retrospective case series. Participants Forty six eyes of 46 consecutive patients with clinically significant macular edema with retinal vein occlusion. The subjects were divided into two groups: macular edema without macular detachment group and macular edema with macular detachment group. Methods All patients received intravitreal anti-vascular endothelial growth factor (VEGF) or posterior Tenon subtenon injection of triamcinolone (TA). The change in refraction (spherical equivalent refraction, SE) between baseline and the final visit without macular edema or the central subfield thickness (CST) measured by optical coherence tomography reached the thinnest level was analyzed in the two groups respectively. Main Outcome Measures SE. Results In macular edema without macular detachment group, the baseline SE, final visit SE and the mean absolute value of SE change was 0.38±1.71 D , 0.32±1.68 D , 0.31±0.32 D, respectively (t=0.577, P=0.571). In macular edema with macular detachment group, the baseline SE, final visit SE and the mean absolute value of SE change was 0.79±1.25 D, 0.26±1.15 D , 0.88±0.81 D, respectively (t=2.541, P=0.017). Conclusions Appropriate spectacle correction can be prescribed to patients with macular edema but without macular detachment any time during ongoing therapy using intravitreal anti-VEGF or posterior Tenon subtenon injection of TA. (Ophthalmol CHN, 2017, 26: 39-43)

Studies on Yiyangjianyin compound prescription in intervening guinea pig form deprivation myopia: eye living parameters measurements 

GAO Ran1，2, MA Dong-li1, LU Qing-jun1, LV Meng1, XIAN Jin-zhui1, PAN Mei-juan1.

2017, 26(1):  44-48.  doi:10.13281/j.cnki.issn.1004-4469.2017.01.012

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 Objective To observe the effect of Yiyangjianyin compound prescription on eye living parameters of guinea pig form deprivation myopia. Design Experimental study. Participants 50 guinea pigs. Method Pigs were divided randomly into normal control group (group A), blank control group (group B), Yiyangjianyin compound prescription intervention group (group C), simple Yangyin compound prescription intervention group (group D). Both eyes of guinea pigs were not stitched up in group A, right eyes of guinea pigs were stitched up in group B, C, D to form deprived myopia model. There was no medicine intervention in Group B. Yiyangjianyin compound prescription intervention instead of water dinking was performed in Group C, and simple Yangyin prescription intervention instead of water drinking in Group D. Type-A ultrasonic was examined to measure eyeball parameters before experiments and after 6 weeks. Main Outcome Measures Vitreous chamber depth, axial length. Result The vitreous chamber depth (3.262±0.208) mm， axial length (7.687±0.256 mm) in Group C was significantly shorter than that of Group B (3.499±0.098) mm and (8.049±0.257) mm. The differences was statistical significance (all P<0.05). Vitreous chamber depth, axial length of right eye in four groups were compared in pairs. The difference was not statistical significance between Group A and C (all P>0.05), which showed the occurrence of deprivation myopia was not obvious in group C with the right eyelid suture. The differences of axial length was not statistical significance between right and left eyes within group C (P>0.05).  Conclusions Yiyangjianyin compound prescription can in some degree inhibit the development of guinea pig form deprivation myopia, which mainly delayed the deepening of vitreous chamber and lengthening of ocular axis.  (Ophthalmol CHN, 2017, 26: 44-48)

Clinical analysis of fungal keratitis in Xishuangbanna Autonomous Prefecture, Yunnan Province in 2004-2014

ZHAO Nan-nan1, WANG Li-tao2, JIN Jing2, ZHOU Qing2, LUO Ping2.

2017, 26(1):  49-51.  doi:10.13281/j.cnki.issn.1004-4469.2017.01.013

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 Objective To analyze clinical features and pathogen of fungal keratitis in Xishuangbanna Autonomous Prefecture, Yunnan Province in 2004-2014. Design Retrospective case series. Participants 599 cases of fungal keratitis patients confirmed by Xishuangbanna Prefecture People's Hospital. Methods All cases were retrospectively reviewed for emographic characteristics, predisposing factors, etiological characteristics and previous treatments. Main Outcome Measures Emographic characteristics, etiology and pathogens. Results Prevalence ratio of male and female was 3:1, with major age range from 35 to 65 (47.5%).  Rural residents were 63.4%. There was a high incidence of fungal keratitis in wet season of Xishuangbanna area (85.4%). 78.4% cases were associated with plant-induced trauma. 32.5% patients had received glucocorticoid medication in early treatment. Fusarium (37.8%), aspergillus (32.7%) were the main pathogenic bacteria of fungal keratitis. Conclusions Young and middle-aged male farmers, plant-induced ocular trauma in rainy season are the main risk factors of fungal keratitis in Xishuangbanna area. (Ophthalmol CHN, 2017, 26: 49-51)

Clinical analyses of 9 cases of superior limbic keratoconjunctivitis of Theodore

ZHANG Xiao-yu, WANG Zhi-qun, ZHANG Yang, SUN Xu-guang.

2017, 26(1):  52-55.  doi:10.13281/j.cnki.issn.1004-4469.2017.01.014

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 Objective To analyze the clinical features, diagnosis and treatment of superior limbus keratoconjunctivitis (SLK). Design Retrospective case series. Participants Nine cases diagnosed as SLK between January 2013 and December 2015 in Beijing Tongren Hospital. Methods All cases were retrospectively analyzed, including clinical manifestation and treatment. Main Outcome Measures clinical manifestation and treatment outcome. Results 7/9 cases were females, and mean age was 40±12 years. All cases were bilateral. All cases had the similar presentation. Slit lamp examination showed palpebral conjunctival papilla, upper corneal limbus infiltration andfluorescein staining. 2 patients were accompaniedby hyperthyroidism, 1 case with ocular symptoms as the first. Topical treatment included artificial tears, low concentration of steriod drugs. Bandage lens were used for heavier infiltration patients. But SLK recurred in four cases, which were cured completely after re-treatment. Conclusion SLK is a chronic inflammation of the upper conjunctiva and corneal limbus, without obvious hyperemia of remaining parts of the bulbar conjunctiva. Most cases are bilateral. Local use of low concentration steroid eye drops combined with bandage lens is effective for it. The treatment of systemic diseases is essential. Clinicians should pay attention to recurrence of SLK. (Ophthalmol CHN, 2017, 26: 52-55)

Research on regulation of rabbit corneal endothelial cells with pressure bionic cultivation

LIANG Ling-ling1, YUAN Jin2, XING Zheng-mao3, LIAO Hong-fei4.

2017, 26(1):  56-60.  doi:10.13281/j.cnki.issn.1004-4469.2017.01.015

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Objective To investigate the morphological and functional of regulations under different pressures culture on rabbit corneal endothelial cells by pressure bionic culture system in vitro. Design Experimental study. Participants Rabbit corneal endothelial cells. Methods The rabbit corneal endothelial cells were divided into five groups: Group A: without pressure culture group, as a blank control group; Group B: normal pressure bionic culture group (15 mmHg); Group C: fluctuated pressures were 15 mmHg, 25 mmHg, 20 mmHg, 10 mmHg, each pressure was for 6 hours; Group D: the cells were exposed to 30 mmHg pressure in vitro; Group E: 50 mmHg pressure bionic culture group. The five groups were cultured for 24 h respectively. Cells origin was identified with neuronal-specific enolase immunoassay. Cellular change in the structure was observed with HE staining and electron microscopy (SEM) test. Cell activity was detected with flow cytometry. Main Outcome Measures Cell morphology and the survival rate of cell. Results NSE antibody of the primary corneal endothelial cells was positive without corneal epithelial cells and corneal stromal cells. Cells were hexagon in the majority, arranged closely and were rich in microvilli and nuclear chromatin in the normal pressure bionic culture group. Survival rate of cell in normal pressure bionic culture group, fluctuated pressures group, 30 mmHg group, 50 mmHg group was (98.16±0.45)%, (78.83±1.65)%, (70.2±3.54)%, (41.33±0.25)%, respectively (P=0.016). However, in other high pressures groups, corneal endothelial intercellular space increased and the cell activity was lower than that of Group B by HE staining and flow cytometry. Conclusions The experiment confirmed that cultivative rabbit corneal endothelial cells morphology and function were positive adjusted with the normal pressure bionic cultivation, but high pressures would cause damage to corneal endothelial cells, and the damage would serious with extended over time. (Ophthalmol CHN, 2017, 26: 56-60)
 

The effects of fluoxetine combining covering of the nonamblyopic eye on the treatment of amblyopia in the adult amblyopic rat

XIE Lai-qing, XU Guo-xu, WEI Xiao-hong, ZHU Yong-ming.

2017, 26(1):  61-65.  doi:10.13281/j.cnki.issn.1004-4469.2017.01.016

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Objective To investigate the therapeutic effect of fluoxetine on the treatment of amblyopia in the amblyopic adult rat. Design Experimental study. Participants Amblyopic adult rats. Methods The rats were grouped to control, Flx2, Flx4, BFD up on different intervention. The rats of control group were drinked conventional water for 4 weeks. The rats of Flx2 and Flx4 group were drinked 20% fluoxetine drinking water for 2 and 4 weeks. Binocular form deprivation was performed on the rats of BFD group for 2 weeks.  Pattern visual evoked potential (PVEPs) were measured in each group after 1 week of covering of the nonamblyopic eye. Main Outcome Measures The amplitude of PVEP, the C/I VEP ratio and the HSD-Q. Results There was a increased response of the amblyopic eye（Flx4 group: from19.86±3.07 to 32.31±4.29 μv, Paired t test， t= -4.938, P＝0.001. BFD group: from 17.51±4.12 to 29.31±2.29 μv, Paired t test, t=-4.301，P＝0.001） and the C/I VEP ratio was changed in the rats of Flx4 （from 1.11±0.29 to 2.34±0.45, Paired t test， t= -2.743, P＝0.016）and BFD （from 1.04±0.28 to 2.45±0.29, Paired t test, t=-3.629, P＝0.007）group. There was statistically significant differience among the C/I VEP ratio of different interventions（F= 18.86, P＝0.018; Control vs Flx2: HSD-Q = 0.13, P＝0.175; Flx2 vs Flx4: HSD-Q=9.76, P＝0.013; Flx4 vs BFD: HSD-Q = 0.09, P＝0.350）. A reduction of the response to stimulation of the nonamblyopic eye (Paired t test，t=2.672, P＝0.047）was also performed in the BFD group. In contrast, one week of covering in the control group and Flx2 group did not change binocularity in the visual cortex of the amblyopic adult rat.  Conclusion Four weeks of 20% fluoxetine drinking and 2 weeks  of BFD may restore visual cortex plasticity in the amblyopic adult rat. Chronic administration of fluoxetine can promote the recovery of visual functions in adult amblyopic rats as tested electrophysiologically and may become a new therapy of adult amblyopia. (Ophthalmol CHN, 2017, 26: 61-65)